bonsai_spool

6 ms·

91.
by bonsai_spool 4mo ago
> The more we measure, the better we get at separating the false positive cases from the serious ones. On what basis do you say this? There is an extensive literature that refutes this. Scanners have been getting much better since the fi
92.
by bonsai_spool 4mo ago
> it's _git gud_ There are physical limits to detection and technical parameters that make some situations indeterminate even for the best of the 'gud'. It is frustrating that, hearing an argument from many different indiv
93.
by bonsai_spool 4mo ago
And Anthropic say they were on the phone within 15 minutes… This administration is not known for its honesty so it’s hard to take their side of things
94.
by bonsai_spool 4mo ago
How does this compare to SpaceX? I’m very much not an accountant, hard to know what numbers to compare directly
95.
by bonsai_spool 4mo ago
Here’s the blog post referenced in the article that’s written by the person who reviewed the paper that purportedly found a ‘jailbreak’ https://www.lutasecurity.com/post/the-fable-5-export-control...
96.
by bonsai_spool 4mo ago
It's not clear that a human was involved in writing this at all
97.
by bonsai_spool 4mo ago
Where does the quote in your profile come form? "It is unfortunate that a large number of users here are not hackers, not even in an idealistic philosophical sense, and will betray the public good for their own short-term gain. You eit
98.
by bonsai_spool 4mo ago
Ah yes, the model card that shows an over 10% improvement in agentic coding among other things! https://www.anthropic.com/news/claude-fable-5-mythos-5
99.
by bonsai_spool 4mo ago
> Interesting to see Anthropic now downplaying the new vulnerabilities that Mythos discovered: That is absolutely NOT what is being said there. They are referring to a very specific thing that you must have clearly seen and chosen to i
100.
by bonsai_spool 4mo ago
> It does not provide an accurate signal for what the results would be if we gave them to less sick people. It provides an excellent signal because we want to prove that these drugs are doing something that the standard of care is unab
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by bonsai_spool 4mo ago
> forbid smoking because the statistics point at it correlating with many health problems, is a world where we use the same statistical tool to prescribe human behavior to the last detail. I had a really great egg for breakfast. This no
102.
by bonsai_spool 4mo ago
> This is why I hate patents. If CRISPR were put behind a paywall, none of this would have happened. Everything having to be about profit is getting tiring. CRISPR was the cause of a huge patent case and likely led to a change in US pate
103.
by bonsai_spool 4mo ago
Here's their preprint from a month ago, in case you can't access the Nature paper: https://www.biorxiv.org/content/10.64898/2026.05.08.723607v1 Nature - https://www.nature.com/articles&#x
104.
by bonsai_spool 4mo ago
> something many people are hoping to solve in healthcare Respectfully, the solution is don't smoke, exercise, eat well, sleep, avoid stressors... These aren't easy problems but their solution isn't at the individual patie
105.
by bonsai_spool 4mo ago
That’s quite fine, I hope it’s an opportunity for you to introspect
106.
by bonsai_spool 4mo ago
> And the insight of having used LLMs and it being so capable is a wtf moment for me in itself. And I am an AI engineer. It’s my job to have a good idea about how far these models can take us. Are you saying that, as an 'AI enginee
107.
by bonsai_spool 4mo ago
Very straightforward biology work is getting blocked (these are things that relate to neuronal development and inherited seizure disorders). These are things I was working on using Opus just earlier today
108.
by bonsai_spool 4mo ago
Do you work in biology? > would be more worried if the blotted area was different (the dark blob) - or if data in a datasheet (something like test specificity, level of detection, etc) was wrong These images are provided on the datasheet
109.
by bonsai_spool 4mo ago
I responded to a sibling: https://news.ycombinator.com/item?id=48440267 > Yes, because the expensive part is making the thing. I'm not sure what 'making the thing' refers to here. We are very far from crea
110.
by bonsai_spool 4mo ago
> Yes because a core reason fro this technology is evaluation of de-novo designs (small peptide binders; scFvs; sdAbs) You are not understanding the distinction. OP was speaking about macromolecular complexes, which are explicitly not wh
111.
by bonsai_spool 4mo ago
> very had to predict what binds to what, which of course is a multi-billion-dollar industry. Do you need to predict when AP-MS is so cheap? Mapping interaction interfaces is challenging and is where there is attention. I don’t think we’
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by bonsai_spool 4mo ago
Not sure if the oligo approach would circumvent this concern, but I had a GC-content issue with gene blocks that precluded me from using them. Twist was able to do the synthesis, however (not sure what platform they use for their synthesis
113.
by bonsai_spool 4mo ago
Yeah... What am I missing? Like why isn't this just laughed at when it's proposed?
114.
by bonsai_spool 4mo ago
For me it makes it easier to study long, alternatively spliced genes. But there are many use cases - you can see them described on vendors’ pages and even in this new post.
115.
by bonsai_spool 4mo ago
> Yes. Whole genome sequencing has We're speaking about gene synthesis, not about DNA sequencing
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by bonsai_spool 4mo ago
This is not a practical challenge - I order DNA from Twist at these ‘large’ scales trivially without needing to do oligo hybridization magic. The DNA arrives in a month - but considering how many oligos sidewinder calls for, not clear how t
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by bonsai_spool 4mo ago
> marketed for decades So why change? You're not building a case for why this change is needed. Is there even another Nasdaq 100 company like SpaceX? Probably not because it would be an obvious point of discussion. So now we need to
118.
In a First, Scientists Precisely Edit Human Embryo Genes(nytimes.com)
7 points by bonsai_spool 4mo ago|0 comments
119.
by bonsai_spool 4mo ago
> US has taken an absolute nose-dive several times over the past decade or two This is also my field... and if the nose-dive is what has delivered in these past two decades RNA-seq, induced pluripotent stem cell generation, CRISPR-mediat
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by bonsai_spool 4mo ago
The reason you can ‘pivot’ into tech is because you’re able to run programs and see their output on your own device. You can do some data-oriented research at home, though you’d also have a lot of reading to do first. Medicine requires seei

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