bonsai_spool

6 ms·

31.
by bonsai_spool 2mo ago
The title of the paper is "Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans" Currently, the editorialized HN page title is "Three Minutes of Sprinting Beat
32.
by bonsai_spool 2mo ago
This bonus, per the thread, has to be accepted for a candidate to get a job offer and has unclear implications for when a worker may leave. In this case it is closest to a 'signing bonus' or stipend as some professional school tra
33.
by bonsai_spool 2mo ago
> Why do you think it is not relevant to the problem of teacher recruiting? First, the issue with teacher pay is that it is low. OP and you would instead say that the issue is that it's not low enough for some low performers, and th
34.
by bonsai_spool 2mo ago
> Teacher recruiting wouldn't be so hard if pay weren't lockstep, as it is in so many places. Unions demand this, and it keeps some potentially-effective teachers out of the profession (and keeps old lousy ones in, unfortunatel
35.
by bonsai_spool 2mo ago
The point is that this bonus is effectively a condition of hiring that has strings attached
36.
Are We Being Railroaded by AI?(tomtunguz.com)
3 points by bonsai_spool 2mo ago|0 comments
37.
by bonsai_spool 2mo ago
> You want to train kids from a young age not to spend a long time on the toilet, which reading encourages. It consistently leads to hemorrhoids. That's just a fact. Whoa, you can preach whatever you'd like, but let's not
38.
by bonsai_spool 2mo ago
> Back when we lived without phones, we used to read instruction labels on all and any household cleaning products that were stored in the bathroom. Wow, I forgot that I used to do this! And I'd puzzle over whether any ozone was lef
39.
Timeline of the OpenAI accidental attack against Hugging Face(simonwillison.net)
1 points by bonsai_spool 2mo ago|0 comments
40.
by bonsai_spool 2mo ago
I hear your hypotheticals about testing. I think this comes up often, by way of example, when somebody has been in the hospital for a long time. Long stays aren't always medical, they're sometimes due to social issues (adult child
41.
by bonsai_spool 2mo ago
And written by an LLM, to boot.
42.
by bonsai_spool 2mo ago
I hear the complaint, all I can say is that everyone I speak to about this wants to diagnose things correctly while not wasting anybody's time or energy on bad diagnostic workups. > Combine this with our (otherwise reasonable) tende
43.
by bonsai_spool 2mo ago
I think endometriosis is common enough that it would be caught earlier ("Oh, does your joint pain get worse right before you menstruate? Tell me more"), but your point is reasonable. I counter with the platitude that common things
44.
by bonsai_spool 2mo ago
This relates to the Midjourney effort; previous HN discussions: - Original: https://news.ycombinator.com/item?id=48579650 (see https://www.nature.com/articles/s41551-026-01660-4 ) - 'I was wrong
45.
The Silicon Valley Health Trend Making Doctors Nervous(nytimes.com)
4 points by bonsai_spool 2mo ago|1 comments
46.
by bonsai_spool 3mo ago
Understood, I responded elsewhere that I read the Lowe article as talking about conceptual advances (ACE, HMG CoA), but I realize he's mixing both erstwhile untreated indications as well as biosimilars.
47.
by bonsai_spool 3mo ago
Not being rude, and I definitely know about medicine. I explained in sibling that I understood the Lowe article to be about new research (as a researcher, I don't often think about how hard it is to make a GLP survive the stomach but I
48.
by bonsai_spool 3mo ago
I did ask for examples. These aren't really the sort of thing the article is talking about - they're just recombinations of existing medications. I admitted in another comment that I wasn't thinking about these but instead la
49.
by bonsai_spool 3mo ago
> Why isnt it rational? You can spend that $1B to win a new category or that same money to maybe be non-inferior to Keytruda, but maybe fail. I think copycat design does happen, but I mostly notice it when drugs are being developed simul
50.
by bonsai_spool 3mo ago
You are correct. I disagree with alternatives being better as a rule but these are clearly areas where there's a market (to wit, people don't like injecting themselves and prefer pills).
51.
by bonsai_spool 3mo ago
I have seen these people, but we are speaking about drug companies making new drugs. I am not aware of an example of a new chemotherapeutic developed to reduce the side effects of a previous agent - that seems even less reasonable from an R
52.
by bonsai_spool 3mo ago
This is very facile thinking - are there any examples of a-e in the real world (namely, a brand new drug program was spun up to exploit a-e) ? I think not, which is why I asked the question.
53.
by bonsai_spool 3mo ago
Cost of manufacture is not a meaningful driver of pricing outside the biological How will your clinical trial of the ostensible full cure work if standard of care is curing people?
54.
by bonsai_spool 3mo ago
That isn’t how a rational person would pursue this - it costs $1B to make a drug start to finish, and there’s no reason to believe your new mechanism will work. If you’re talking about copycat mechanisms, that is fine but we’re still left d
55.
by bonsai_spool 3mo ago
This comment makes no sense. Why would anyone make a drug if the current prevalent treatment was as good as a functional cure? What do lorbrena and keytruda have to do with the rate of failures being constant?
56.
by bonsai_spool 3mo ago
Wow, you’re my twin! I’d watch these on XBMC/Xbox Media Center with some other video podcasts - it was a magical moment in tech
57.
by bonsai_spool 3mo ago
What does the ‘I’ stand for in DEI? Say a man thinks nursing is for women and not for men. Say an employer wants more nurses irrespective of sex. Is that employer engaging in DEI if they spend more money on male re-education than on recruit
58.
by bonsai_spool 3mo ago
Why not touch or echo? No reason for an editor or cat
59.
by bonsai_spool 3mo ago
This is from February 2026 and notably there’s no way for the public to try out the model, nor is it published in a peer-reviewed journal
60.
by bonsai_spool 3mo ago
> I wish the doctors had been clearer with us about his chances of survival What would they have done differently from what they actually did?

More ›