biophysboy

5 ms·

61.
by biophysboy 4mo ago
I used to order $10 oligos all the time. The extra length is cool, but I was honestly more impressed by the claims on sequence accuracy in the article. Even a single base pair change can affect the genetics and physics of DNA. I broadly agr
62.
by biophysboy 4mo ago
That number is for the United States, not the United States government
63.
by biophysboy 4mo ago
There is evidence that high-frequency, 50% accurate bot traders make most of the money on prediction markets simply due to being able to make bets faster.
64.
by biophysboy 4mo ago
Is the 5% rule for total rent per year?
65.
by biophysboy 5mo ago
Protein structure is not a rate-limiting step in drug discovery.
66.
by biophysboy 5mo ago
The way I put this to myself is that AI gives “correct correct answers and incorrect correct answers”. They almost always generate logically correct text, but sometimes that text has a set of incorrect implicit assumptions and decisions tha
67.
by biophysboy 5mo ago
Yes, I hear you on how academia chases metrics. I would argue this phenomena is not worse than Company Z making a boilerplate AI chat tool that is no more useful than the flagship popular products. I think the fairest comparison is comparin
68.
by biophysboy 5mo ago
Transformers are an applied science: https://patents.google.com/patent/US10740433B2/en Basic research would be something like optimal control theory, which came well before the transformer design. I'm not try
69.
by biophysboy 5mo ago
Departments base grad school admissions on grant awards. The article states: grant awards for MIT went down more than 20%, then new MIT grad students went down 20%. The decrease in students has nothing to do with academia being detached fro
70.
by biophysboy 5mo ago
It is a real shame too, because industry is completely incapable of doing basic research. Universities make the fuzzy ideas, and companies turn them into widgets. The only exceptions in history to this are the monopolies, which have their o
71.
by biophysboy 5mo ago
Obviously there is a selection effect that confounds any causal comparisons between those who do and do not get into MIT. But the better counterfactual is students who are accepted but do not attend. A diff-in-diff study with these two grou
72.
by biophysboy 5mo ago
This is all true, but I think the main cost is the time wasted. The opportunity cost is enormous for humanity.
73.
by biophysboy 5mo ago
Albert Hirschman wrote a great book about the rhetoric people use to stifle policy proposals 35 years ago. “It’s futile; it won’t ever work” is one common argument. It’s not a meme so much as a cynical reflexive intuition
74.
by biophysboy 5mo ago
pulling back as in setting more realistic token budgets, or something more drastic? I'm curious
75.
by biophysboy 5mo ago
Entry ticket, basically. I went to Olympic Natl park recently and had the pass added to my Apple Wallet.
76.
by biophysboy 5mo ago
I don't really think of it as an app; I think of it as the "double-tap side button to do tap to pay or present my ticket" iPhone feature
77.
by biophysboy 5mo ago
Fair point - a combo might be the best approach.. I understand the idea of accidents correlating w/ miles driven, but it seems to be optimizing for driving safety rather than human life? Does that make sense?
78.
by biophysboy 5mo ago
Honestly, just per 1M person per year. If this normal incidence went up while the exposure incidence rate went down over 20 years, I'd wanna know.
79.
by biophysboy 5mo ago
Coming from a bio background, I’ve always been confused why auto fatality stats are normalized per miles driven. Epidemiological metrics like incidence or prevalence seem like they would work fine? Town A would be “safer” than town B if peo
80.
by biophysboy 5mo ago
A better time range would be the average species lifespan of the plants and animals we eat. Too short a range highlights noise; too long a range highlights unrelated data.
81.
by biophysboy 6mo ago
I finished a PhD. My concrete advice is focus on feasible methods you know are realistic for your lab resource wise (time, money, etc)
82.
by biophysboy 6mo ago
Along with parsing various file formats, you can create duckdb files to store tables, and make related views, schema, etc. They also have a newer ducklake tool
83.
by biophysboy 6mo ago
I think a good corollary idea to "vibe coding" is the "vibe product". There is so much stuff popping in and out of existence and my excitement has declined.
84.
by biophysboy 6mo ago
Is this book just riffing about embedding space? I thought about reading it eventually, but the quoted passage is kind of annoying/tedious
85.
by biophysboy 6mo ago
Tech still broadly respects edgy, hot take contrarianism, even if they think Andreessen is stupid in this instance.
86.
by biophysboy 6mo ago
Introspection is not doomscrolling though. Being tugged around by short-lived stimuli from a feed is the opposite of deep self-reflection. In order to go from reading the news to going outside and doing yardwork, you need to have a thought
87.
by biophysboy 6mo ago
I had to, and I work in a completely different agency (NIH)
88.
by biophysboy 7mo ago
how many habeas petitions were there in previous admins?
89.
by biophysboy 7mo ago
Ha! That seems like a waste. As I said, commute time determines whether its worth it.
90.
by biophysboy 7mo ago
That's definitely true - ideally, there would be one day where almost everyone comes in for the all-hands meeting. Whether that is realistic depends..

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