bglazer

16 ms·

181.
by bglazer 3y ago
Which genetic variants were selected out of the population (in one generation), and how did they lead to decreased brain size? I’m asking this because you think genetic selection happened to change brain size. This level of genetic selectio
182.
by bglazer 3y ago
This is all, for lack of a better term, pie in the sky bullshit. “I'm extremely uninterested in the specifics of eugenics”. At least this is quite evidently true. And that's the problem. Sometimes details actually matter a great d
183.
by bglazer 3y ago
This whole thread started with you making some quite confident, and evidence free, statements about genetics. All I did was ask for any evidence for the theories you believe in. Instead you lectured me about cults and openmindedness. I woul
184.
by bglazer 3y ago
Yeah ok, open mindedness is lovely. Cults bad, got it. Which genetic variants were selected out of the population (in one generation), and how did they lead to decreased brain size?
185.
by bglazer 3y ago
There are two explanations here: 1. We got richer and thus got better medical care, better food, cleaner conditions. Education got better and longer. Thus, brains grew slightly bigger. 2. Some other phenomena (?) occurred that caused a one-
186.
by bglazer 3y ago
“The study imaged the brains of more than 3,000 Americans, between the ages of 55 and 65, and found that those born in the 1970s have a 6.6 percent greater overall brain volume than those born in the 1930s.“ 40 years is not a relevant times
187.
by bglazer 3y ago
They’re snipping another gene (BCL11A) that silences, or turns off, HbF. Turning off BCL11A then allows HbF to be expressed
188.
by bglazer 3y ago
Wacky entrepreneur moves in, builds go kart track in abandoned warehouse. No safety precautions are taken whatsoever. Kids come for birthday party. Go kart catches on fire, the warehouse fills with smoke. The kids die. For a less hypothetic
189.
by bglazer 3y ago
CRISPR, in the form used by Vertex, is not capable of directly repairing an existing gene. In the case of sickle cell this means directly changing the mutated nucleotide in the HbA gene. CRISPR is very capable of cutting the genome at pre
190.
by bglazer 3y ago
Paul Saladino has been saying that APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia?
191.
by bglazer 3y ago
The problem with this is that it is utterly ahistorical. Like it completely ignores every observation you could make about how wealth was historically allocated.
192.
by bglazer 3y ago
First, you're the popular resistance to AI research. The movement already exists and is already prominent enough to be written up in the New Yorker. If your response is that the resistance is just a small set of people in SF, then I wo
193.
by bglazer 3y ago
That’s a political question. It would require maintaining popular resistance to giving over all critical segments of the economy to AI. Of course that would be difficult, given the short term gains that would bring, but people seem pretty g
194.
by bglazer 3y ago
I absolutely believe researchers (possibly assisted by AI) will eventually create an AI better than humans at inventing technology. My idea is that actually building and sustaining technology requires a lot of hands. Until the AI has enough
195.
by bglazer 3y ago
Thanks for sharing, Christiano’s ideas are interesting. I think the “production web” idea most directly counters what I said above, and it’s fairly convincing. Critically though, it posits that humans are basically asleep at the wheel durin
196.
by bglazer 3y ago
It gives us as long as we want. Just don’t give the AI enough robots to sustain its own existence. In the meantime we can figure out either alignment or coexistence.
197.
by bglazer 3y ago
In any doom scenario, like let's say >90% of humans dead, who runs the power plants that supply the AI data centers? Who runs the fabs producing more chips? Who maintains the plumbing? Presumably all these systems fall over and die
198.
by bglazer 3y ago
EDIT: I shouldn't have replied to this
199.
by bglazer 3y ago
Jet fuel isn't leaded. It’s piston engine general aviation aircraft that use leaded gas.
200.
by bglazer 3y ago
The article says 400 milliwatt power draw. Wolfram Alpha says thats roughly equivalent to cell phone power draw when sleeping.
201.
by bglazer 3y ago
From a quick scan, this reads like a very pure example of crank nonsense. Unified theory of everything with sparse and incoherent math. Lots of describing how revolutionary the theory is, very little actual theory
202.
TripoSR: Fast 3D Object Generation from Single Images(stability.ai)
2 points by bglazer 3y ago|0 comments
203.
by bglazer 3y ago
It’s more of an engineering accomplishment. I could see this being useful for exploratory data analysis of large protein (mesoscale) complexes. A surprising amount of science starts with a grad student staring at a really complex plot for a
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by bglazer 3y ago
Just curious, why do you listen to Jack Benny? Job? Hobby/personal interest?
205.
by bglazer 3y ago
Children with Down syndrome have high rates of severe heart defects. These are treatable with surgery now. So I think you’re wrong in assuming mistreatment or neglect just because the children died young.
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Sophie Wilson – Codesigner of ARM Instruction Set(en.wikipedia.org)
4 points by bglazer 3y ago|0 comments
207.
by bglazer 3y ago
This is already done. There are many labs currently looking for "synergistic" combinations of treatments.
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by bglazer 3y ago
This is great. My mom does embroidery as a hobby and I’ve been curious about how to make designs. They’re incredible machines
209.
by bglazer 3y ago
For this to be prospective rather than retrospective, they would have developed the risk model beforehand.
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by bglazer 3y ago
One caveat is that this is necessarily a retrospective study. The authors looked at historical data from the UK Biobank, ran a regression, and found these genes. So, it’s not really clear if these genes are actually causing dementia, or if

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