avogt27

4 ms·

1. 1.▲
   by avogt27 1y ago

   Pedantic semantics gripe: DNA damage refers to actual damage to the DNA molecule (breakage of the sugar-phosphage backbone, loss of nucleosides, etc). DNA accumulates MUTATIONS over time, which lead to the loss of genetic fidelity. Many can
2. 2.▲
   by avogt27 1y ago

   Several crystal structures of the catalytic domain of the protein had already been determined. The DNA binding domain of the protein which AlphaFold predicted is a relatively common fold that probably could have been figured out using homol
3. 3.▲
   by avogt27 1y ago

   I agree that this is probably at least partially a motivation, but it seems like a losing strategy to me. AlphaFold is run by a private company, and falsely elevating the importance of its use in the paper could be used to fuel the argument
4. 4.▲
   by avogt27 1y ago

   I think my problem is that this is maybe the most minimal and mundane use of AlphaFold, but it is treated like one of the main points of the paper. The small molecules they tested were already known to inhibit this enzyme, the structural mo
5. 5.▲
   by avogt27 1y ago

   It's really a bummer to see this marketed as 'AI Discovers Something New'. The authors in the actual paper carried out an enormous amount of work, the vast majority of which is relatively standard biochemistry and cell biolog