arkades

56 ms·

481.
by arkades 7y ago
If they’ve raised capital for a series of clinical trials, you can reasonably assume the doses at which they expect to see clinical effects are much higher than you’re likely to get just from food ingestion - otherwise their competition wou
482.
by arkades 7y ago
Phase 1 study. Years from market.
483.
by arkades 7y ago
1) Metabolic side effects tend to be slow and subtle. Vioxx caused increased heart attacks over time. Passing a phase 1 safety trial is fine and dandy, but it’s a far cry short of long-term safety in a drug targeting metabolism, and it’s no
484.
by arkades 7y ago
Methylation and acetylation of sex chromosomes is inherited. In somatic tissues it affects downstream development; in gonads, it becomes a heritable trait.
485.
by arkades 7y ago
What's the produce selection and quality like? I tried Prime Now, Peapod, and Freshdirect so far. FD is the most reliably good, but there's no same-day delivery, and it's the most expensive. Peapod also has no same-day, often
486.
by arkades 7y ago
Pythonista ( http://omz-software.com/pythonista/ )
487.
by arkades 7y ago
They didn’t generally refer to it explicitly as epigenetics - they tended to cover the exact mechanisms. Check out pg 358’s dedicated subsection to methylation, for example. The word epigenetics won’t be mentioned, but it’s one of the clas
488.
by arkades 7y ago
So, the edition you’re linking, you’ll likely find epigenetics in ch21, genetic basis of development. That’s usually where the older books discussed methylation and acetylation.
489.
by arkades 7y ago
My niece spent 30 seconds on the App Store and now has a place to write and run python scripts on her iPhone. Cost to entry was basically zero.
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by arkades 7y ago
This is the ToC I found: https://www.pearsonhighered.com/assets/preface/0/1/3/4/01348...
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by arkades 7y ago
I was shocked by the line in the article that mentioned years, plural, of schooling to become a stenographer. Apparently, although many states do not require a license to be a court reporter, if you want professional licensure, you need an
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by arkades 7y ago
So I don’t have a copy of Campbell’s underhand, but a quick google search for its table of contents brought up the ToC for 7e. Chapter 9, pg 161 covers epigenetics, p 162 gene linkages, Ch11 covers gene methylation. I’d find additional spec
493.
by arkades 7y ago
A web page from 2014 summarizing an article not about the safety consequences of removing password masking, but the effect of removing masking on consumer trust . Performed and written by a UI guy. No link to the academic article it's
494.
by arkades 7y ago
Very possibly reversing causality. That Brookings paper itself states that the economic downturn predates the 'opioid epidemic'. It's based on data that adds up to little more than, well, what you quoted - with little effort
495.
by arkades 7y ago
Every biology, molecular biology, and genetics textbook made for freshmen and sophomore bio majors. You can't pick a wrong one - this has been core material for at least two decades.
496.
by arkades 7y ago
An overview of a museum exhibit of manga, the (after reading the article, I'd say clickbaity) title isn't addressed until the very end of the article: >Critics will lament that such a disposable medium does not belong in an est
497.
by arkades 7y ago
> Many people (including myself), don't want a laid back work culture. I want to kill myself for the firm, and work as hard as humanly possible. I think I just derive the most happiness from working (though I do like drinking as wel
498.
by arkades 7y ago
I hesitate to give anything resembling medical advice to someone whose medical details I do not know, and can't follow up with. Speaking in broadest generalities: 1. The kidney stone risk a/w calcium carbonate intake has not been
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by arkades 7y ago
Because the Medknow journals are notorious scam journals that will publish absolutely anything at all, without even a semblance of peer review? There's a difference between non-prestige journal and vanity press.
500.
by arkades 7y ago
It’s fundamentally the long-tail problem coupled with the low bandwidth nature of message boards. In real life, pretty much everyone you meet is kidding, and the whackos usually send many additional red flags. On 4chan, you collect the more
501.
by arkades 7y ago
And a source for that? There have been some very weak recent studies on PPIs and long-term dementia risk that look very flimsy. Other than that, I’m unaware of “long term damage.”
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by arkades 7y ago
Tums after every meal is actually a really good way of getting electrolyte imbalances, to the point of developing kidney stones from the amount that the kidney has to excrete to try and keep things on an even keel. If you need tums after ev
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by arkades 7y ago
Do you have any sources for that statement? I haven’t read anything to that effect, and I’d be interested in finding out more.
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by arkades 7y ago
200mg is a decent bump on average daily intake (360mg), and mag isn’t managed as well as other ions. If you don’t already, please have your doc check your mag levels every couple of months while you do this. Hypermagnesemia is no joke.
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by arkades 7y ago
Hospitals take compliance issues very seriously; the incentives are skewed highly in one direction. Consider it an extension of "HR is there to protect the company, not you." Compliance is there to protect the hospital, not the in
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by arkades 7y ago
Yeah, the IRB isn't even within spitting distance of a HIPAA issue. They're entirely different things, handled by different regulatory agencies, and administered in different parts of a hospital (if a hospital even has an IRB, as
507.
by arkades 7y ago
And that OCR is also a load of shit. I had an office emailing me their appointment data for a patient; I don't know if we had a similar email or something. I responded the first two times I received it that it was being sent in error,
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by arkades 7y ago
Oh, don't misunderstand me. Their understanding is alllllll full of false negatives and false positives, absolutely. But I was specifically referring, as a pain point, to how often offices use HIPAA as an excuse to not do things patien
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by arkades 7y ago
Bonus points that most medical offices have only a vague idea what HIPAA actually includes. 80% of the time an office says "we can't do the thing you're asking us to do, it's a HIPAA violation," it's not a HIPA
510.
by arkades 7y ago
The XKCD is spot-on here. > “In one patient, we destroyed 96 percent of the tumor cells” that crossed the laser beam, says Zharov. Just want to clarify: tumors will generally drop hundreds of thousands to millions of cells into the blood

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