antichronology

5 ms·

1.
by antichronology 1y ago
This is really interesting - I'm going to be honest I'm not an immunologist so this is my (LLM assisted) understanding of your comment: The immune system recognizes a sugar as a PAMP, or Pathogen-Associated Molecular Pattern, whic
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by antichronology 1y ago
> finding sequences on NIH Almost! Yes most of the data is on NIH sub-institutes. For us we take most of the data from NCBI and intelligently pair it together. The training objective of our model takes pairs of sequences (thus the Joint
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by antichronology 1y ago
That would be really cool. Navigating SRA and mining out reasonable $ relevant tasks is a huge bottleneck. I find it takes a large amount of effort to parse what the authors are doing, whether the data is high quality, and how to pre-proces
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by antichronology 1y ago
Here is the link for benchmarks and their utility: https://youtu.be/JdT78t1Offo?t=1444 "We have internal benchmarks. Yeah. But we don't we don't publish them." "we have internal benchmarks that the
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by antichronology 1y ago
Thanks for engaging. Do you mind elaborating on your stance? From where we sit - there are people with diseases and mRNA is an effective way to revert them to a healthy state. I'd be interested to hear more where you're coming fro
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by antichronology 1y ago
I watched an interview with one of the co-founders of Anthropic where his point is that although benchmarks saturate they're still an important signal for model development. We think the situation is similar here - one the challenges i
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by antichronology 1y ago
Huge fan of the work! I'm a big fan of papers from Seelig lab :)
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by antichronology 1y ago
We haven't looked into this deeply yet sounds interesting. Do you have any resources where to start looking at this? Feel free to reach out to us founders@blankbio.com
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by antichronology 1y ago
We think that Orthrus can be applied in a bunch of ways to non-coding and coding RNA sequences but it's definitely fair we're a bit more focused on RNA sequences currently instead of non-coding parts of the genome like promoters a
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by antichronology 1y ago
This is a really interesting direction. There is this big field of Cell Free (cfRNA) cancer detection. We talked to a few people in the field and think that embedding sequences for this direction could be really valuable. One challenge here
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by antichronology 1y ago
> ground truth Hey yes, the ground truth for our evaluations is measured experimental data. Our models are benchmarked using mRNABench, which aggregates results from high-throughput wet lab experiments. Our goal, however, is to move beyo
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by antichronology 1y ago
There is a number of different technologies. Some of the big ones are: - mRNA therapies: These therapies deliver a synthetically created messenger RNA (mRNA) molecule, typically protected within a lipid nanoparticle (LNP), to a patient&#x27
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Launch HN: BlankBio (YC S25) – Making RNA Programmable
63 points by antichronology 1y ago|29 comments
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by antichronology 4y ago
I think the apt comparison here is landing on the moon. Although overtly it carries little value, the technologies developed along the way are very valuable. As the article mentions improved fertilization, more accurate genome editing, and
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by antichronology 4y ago
There is a great novel on a related topic: Permutation city by Greg Egan. The concept is similar where the protagonist loads his consciousness to the digital world. There are a lot of interesting directions explored there with time asynchro
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by antichronology 4y ago
Science Twitter is a really powerful tool for learning about new papers and being able to discuss with authors directly
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What neural networks sound like during training(blog.christianperone.com)
1 points by antichronology 5y ago|0 comments
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by antichronology 7y ago
Where is the proof that human "rational" thinking is anything but curve fitting? I'm not convinced
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Crispr editing DNA in human sperm(npr.org)
2 points by antichronology 7y ago|0 comments
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by antichronology 8y ago
One of the top scientists of 2018 compiled by Nature was Jess Wade[0]. Her achievement is contribution to wikipedia specifically highlighting contributions of women and POC. When 90% of Wikipedia editors are men their biases must reflect in
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by antichronology 8y ago
google maps has a lot of ratings and I find is good at suggesting a list of places from which I can select one. Look into the explore around me feature
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by antichronology 9y ago
Its possible that its better to leave the option more inaccessible to further incentivize yourself from reverting back to color mode. Maybe those few extra steps of converting back to color will stop you from doing so
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by antichronology 9y ago
Has anyone tried changing their computer display to grayscale as well? I tried it for a bit but found that code syntax lacks color. Also graphics in papers all of a sudden are infinitely less informative (elucidating blue from red is really
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by antichronology 9y ago
I'm wondering if personally keeping track of it somehow skews the statistics. Maybe the change is significant but overall not that big something like ~10% I would be interested in cranking through the data myself to see how my phone st
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by antichronology 9y ago
Probably similar to how a lot of Russian people are unwaveringly support Putin's continuous rule
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by antichronology 9y ago
provide an economic argument for not implementing additional authoritarian policies. Seems that these decisions are incredibly hard to measure. For example how much did Turkey's economy suffer from the previous failed coup?
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by antichronology 9y ago
I wonder if it will have some sort of long term impact on the economy. Is there a way of measuring relative government authoritarianism on economic development of a nation?