ak217

14 ms·

181.
by ak217 3y ago
Even better, my COROS is priced at $200 and lasts three weeks. (I mention this because I started to question Garmin a few years ago because they paid a ransom after they got hacked, and then I realized that COROS undercuts them on price by
182.
by ak217 3y ago
Yep - metagenomics/phylogenomics practitioners have learned the hard way that trying to focus on species definitions gets you nowhere (if you think defining a species in multicellular sexually reproducing eukaryotes is hard, wait till
183.
by ak217 3y ago
Selenium is much more toxic than gallium, so even if it could be tweaked to work, it's a very hazardous chemical to produce or recycle. I'd expect that to be the main reason nobody bothers with zinc selenide anymore.
184.
by ak217 3y ago
Your metric is too simplistic. I'm not an expert in 1933 German politics, but the Russian state is quite involved in engineering the appearance of political choice. The FSB and friends ("siloviki") do hands-on screening of ca
185.
by ak217 3y ago
Your understanding of the term "bootstrapped" is warped by the environment you are operating in. The traditional understanding is "building a business without taking on dilutive funding". This has always been hard, but i
186.
by ak217 3y ago
Tsar, singular. One tsar was relatively liberal, Alexander II. He did well under the circumstances, but his good deeds were overwhelmed by the imperial family and system that he was a part of.
187.
by ak217 3y ago
It's not that difficult. You just appoint an auditor and make the bank pay progressively higher fines until they figure it out. American banks learned to be much better at it after 2008. And given 2008 and the MBS balance sheets at c
188.
by ak217 3y ago
Yeah, now that you mention it, that seems like a major issue. Of course unlabeled nucleotides will outcompete labeled ones, they're smaller so they get less steric hindrance. And I don't understand what can be done about it at the
189.
by ak217 3y ago
$200k for a better polymerase was definitely way too low a decade ago, when PacBio had an enzymology group with a multi-million $ budget running crystallography at SLAC to build a better polymerase. On the other hand, $200k might be enough
190.
by ak217 3y ago
It's been a while since I caught up with the field, and this sounds exciting. I'd like to learn more about what exactly has expired (or will expire?). Is it just the reversible terminator patents, or is there more? Is this the mai
191.
by ak217 3y ago
This is super interesting and a promising development for those of us dreaming of running a lab out of a garage. I've never worked with Rothberg directly, but I've read great stories of him cultivating entrepreneural talent in mol
192.
by ak217 3y ago
Interest rates followed a downward trend overall throughout the 80s and 90s, with a few brief spikes and a 5% plateau between 1995-2000. We started the 80s with sky high rates from the Volcker inflation era. Ultimately, interest rates halve
193.
by ak217 3y ago
Most SSO runs on SAML, which uses XML Signature, which uses PKI certificate chains without TLS. Even if you think all SSO will migrate to OIDC, the EU has enacted laws around electronic signatures that basically enshrine the use of XML Sign
194.
by ak217 3y ago
PKI uses are not limited to TLS, and TLS uses are not limited to those where revocation information is readily accessible (due to proxying/distribution/compartmentalization/federation constraints). There is a variety of signa
195.
by ak217 3y ago
[Not OP] CRL/OCSP (which are the only revocation mechanisms close to being generally used standards today) require either online verification (which is unsuitable or unsafe for many applications) or CRL distribution with CA trust root
196.
by ak217 3y ago
This is an absolute game changer for the ability to write secure PKI-based software in Python. Before now, you had to use pyOpenSSL (ignoring its warning to not use it for anything other than an SSL connection) and avoid the many footguns a
197.
by ak217 3y ago
I'm amazed at how little district heating is used in northern climates like Canada and the northern US. In dense areas, district heating using waste heat from power plants should really be required by urban planners, or at least it wou
198.
by ak217 3y ago
> if an employee undermined leadership's authority, it is likely that they won't last long. It is hilarious that you (and many other people in this thread, it seems) would consider this letter "undermining leadership'
199.
by ak217 3y ago
Yep. Nvidia spent 20 years maneuvering and creating the trends and markets they are now benefiting from. Anyone saying they've just been benefiting from a boom like it was some sort of complete externality has not been paying attenti
200.
by ak217 3y ago
Yeah, it's interesting to compare Nvidia's strategy to Intel's. I'm sure there are quite a few Nvidia projects that have been cancelled or even acquisitions liquidated, but they all seem to be small. Every significant pa
201.
by ak217 3y ago
I keep seeing this repeated, but it's obviously not true. ATC does not work on any such basis. ATC's job is to safely and efficiently route the traffic. Different traffic may have different needs, and if unexpected needs arise, AT
202.
by ak217 3y ago
I think the FAA leadership is ultimately in the wrong for allowing their area of responsibility to deteriorate to the point where a controller and a pilot were put in this situation. They have a controller shortage that they are not doing e
203.
by ak217 3y ago
Thanks for noting these. From my experience, neither can replace terraform (though Pulumi might be on the right track). Neither come anywhere close to the Terraform AWS provider, and tightly coupling my IaC to Kubernetes is a non-starter fo
204.
by ak217 3y ago
It's true that the licensing change is a turnoff, but Terraform redefined an industry. What's the alternative? (I'm hoping Mitchell is going to have an answer to that)
205.
by ak217 3y ago
I think those are great examples of platforms that are not practical - they are only used in situations where they absolutely must get a plane to take off/land vertically, no matter the cost (in maintenance overhead or efficiency). I
206.
by ak217 3y ago
You don't need thrusters (which would be impractical). I think you can get most of the benefit by sensing with tiny canards in the front next to pitot tubes, and using electric motors to adjust ailerons/flaperons/spoilerons m
207.
by ak217 3y ago
I think Boeing has had some difficulties. They have also had some undeniable successes. The 777 and 787 programs have no in-service passenger fatalities attributable to engineering errors to date. That's a monumental achievement.
208.
by ak217 3y ago
I don't think that's the right way to reason about it. I find that I can learn a ton from those industries, and as a software engineer I have the added advantage of being able to come up with zero-cost (or low cost), self-docume
209.
by ak217 3y ago
I have my doubts that those are good choices. But I would cautiously suggest Stephenson and Vinge.
210.
by ak217 3y ago
I'm very familiar with the history of CI platforms before GitLab, having used Hudson, Jenkins, Circle, Travis, Appveyor, Codebuild, and a whole bunch of other platforms extensively. While some of them had these features, none of them h

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