aaavl2821

13 ms·

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by aaavl2821 7y ago
It may be that they just presented an abstract and the manuscript has not yet been submitted for publication or peer reviewed
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by aaavl2821 7y ago
didnt find a link to the abstract, seems the results are just being published link to the trial on clinicaltrials.gov is here: https://clinicaltrials.gov/ct2/show/NCT04261517 patients in both tx and control arm fa
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First hydroxychloroquine randomized controlled trial: results disappointing(twitter.com)
199 points by aaavl2821 7y ago|89 comments
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by aaavl2821 7y ago
because nothing is known to work yet for covid-19, doctors are doing the best they can with limited data. this means using unproven drugs for which, to the best of our knowledge, the risk-beneift is favorable. HCQ for covid-19 is an examp
95.
by aaavl2821 7y ago
You can't assume the top line effect size is real without critiquing the study design in detail. A lot of experienced drug developer think the data suggests that HCQ may be marginally effective, but Azt + HCQ seems promising. THere a
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by aaavl2821 7y ago
Many doctors are already actively prescrbign this. I heard that it is basically de facto standard of care in France. Doctors recognize that when eveidence based medicine doesn't provide an adequate treatment, they need to improvise. Of
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by aaavl2821 7y ago
I don't see a contradiction. The CDC is trying to maximize public health benefit. They recommend stronger protection for people with more exposure to higher levels of the virus. Coincidentally, the people with higher levels of exposure
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by aaavl2821 7y ago
The CDC does not say that only n95 or better are worth pursuing https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/f...
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by aaavl2821 7y ago
That is a misleading statement. The CDC has in fact changed its recommendations to recommend in a crises, even HCPs use home-made masks [0] Health care providers, scientists and health officials are rapidly changing and adapting to the sit
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by aaavl2821 7y ago
It may be early to conclude that azithromycin has a complementary mechanism with HCQ, the study was too small and there are too many confounding factors. It is possible there is some synergy but also possible that there is not
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by aaavl2821 7y ago
Fwiw, Plaquenil is hydroxychloroquine, a less toxic derivative of chloroquine. It has a different safety profile than chloroquine The French study of HCQ had several limitations. Including that it was very small and some patients who got HC
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Ask HN: Any clinical trials / RWE companies studying HCQ for Covid-19?
3 points by aaavl2821 7y ago|0 comments
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Hospitals Facing Coronavirus Are Running Out of Masks, Other Key Equipment(wsj.com)
2 points by aaavl2821 7y ago|0 comments
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by aaavl2821 7y ago
All of the things you've said about mask functionality, reusability and sterilization are very interesting. As is your experience with in-home caregiving. Is there a quick, effective and easy sanitizing protocol for N95 masks that you
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by aaavl2821 7y ago
I'm sure hospitals in Seattle, new Rochelle, Santa Clara and San Mateo counties, and LA county could use them. Really any county. 10 masks would be really helpful
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by aaavl2821 7y ago
That may be true. However, if you are a normal citizen (not a healthcare worker) and you have N95 masks, you should strongly consider donating them to healthcare providers right now There are huge shortages of these masks in most US hospit
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Why N95 masks are hard to make(npr.org)
282 points by aaavl2821 7y ago|353 comments
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Tell HN: Support your health care providers
3 points by aaavl2821 7y ago|0 comments
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Video: how top biotech VCs evaluate companies [video](youtu.be)
2 points by aaavl2821 7y ago|0 comments
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by aaavl2821 7y ago
I agree, so many of these studies are not very high quality, and there is so much money behind the scenes trying to push agendas -- between pharma lobbies, hospital lobbies, payer lobbies, and politicians capitalizing on public anger at pha
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by aaavl2821 7y ago
Does the study also look at lower provider and hospital costs? Spending on hospital and providers makes up ~50% of US healthcare spend according to CDC. Rx spend is between 10-20% and admin overhead is 30% or so I wonder why this paper did
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Startup School – An Inspiring Room Full of Hackers(whatisleft.org)
3 points by aaavl2821 7y ago|0 comments
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How to start a biotech startup: 5 VC-backed founders share their stories [video](youtube.com)
2 points by aaavl2821 7y ago|0 comments
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A case study on engineering gene circuits with synbio(baybridgebio.com)
2 points by aaavl2821 7y ago|0 comments
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Biotech Startup School(baybridgebio.com)
2 points by aaavl2821 7y ago|0 comments
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Nature will publish peer review reports as a trial(nature.com)
239 points by aaavl2821 7y ago|105 comments
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by aaavl2821 7y ago
There are about 40-50 biotech startup IPOs every year. $14B was invested in biotech startups last year and ~75% of that goes to r&d
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by aaavl2821 7y ago
This article (like most articles about VC) doesn't mention biopharma VCs. Biopharma is the 2nd largest sector of VC after software -- $14B invested in 2019 [0] (disclosure: source is my site) -- and all they do is fund R&D heavy st
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by aaavl2821 7y ago
this describes a t cell receptor that recognized and killed cells from several cancers while sparing healthy cells theoretically this could may made into a therapy by taking t cells from patients, modifying their DNA to express this recepto
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Who makes the most profit in US healthcare?(bain.com)
2 points by aaavl2821 7y ago|0 comments

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