a_bonobo

67 ms·

1. 901.▲
   by a_bonobo 10y ago

   I was #150 but moved down a bit, one guy I'm doing the course with got into the 90s (but I think moved down a bit too)
2. 902.▲
   by a_bonobo 10y ago

   I'm now in week 4 of the first round of this MOOC (here: http://course.fast.ai/ ) and it's incredibly intuitive, highly recommended. It's less about the mathematics, more about what has been proven to work, a
3. 903.▲
   by a_bonobo 10y ago

   Wikipedia on the Nasser expulsions, didn't know about this before: >As a result of the Suez Crisis, Nasser brought in a set of regulations imposing rigorous requirements for residency and citizenship as well as forced expulsions, mo
4. 904.▲
   by a_bonobo 10y ago

   There are many things you can do with the association, here's a non-exhaustive list: - do the SNPs cause changes in a gene of interest? are the changes synonymous (cause base change, but the protein amino acid is identical since severa
5. 905.▲
   by a_bonobo 10y ago

   Have you read DeMarco/Lister's Peopleware? The main hypothesis is that projects (companies) mainly fail because of sociology (culture) and not because of lacking technology, to quote: >The major problems of our work are not so
6. 906.▲
   by a_bonobo 10y ago

   It works for me- go to https://twitter.com/settings/your_twitter_data and scroll alllllll the way down, there's a link to 'Twitter Archive'
7. 907.▲
   by a_bonobo 10y ago

   I'd say the primary motivation for the sequencing efforts is that we're hitting the limits at what we can detect using SNPs. We now know of many inversions, deletions, insertions which are linked to phenotypes, and often you don&#
8. 908.▲
   by a_bonobo 10y ago

   I work a bit in the field - GWAS is still not identifying causal variants, only linked variants. There are tons and tons and tons of publications that keep on getting published on running similar datasets with the same methods (PCA, regress
9. 909.▲
   by a_bonobo 10y ago

   I see! But that's a bit hard to prove, isn't it? I don't think we have enough archaeological sites with proven fire places to prove that assumption
10. 910.▲
    by a_bonobo 10y ago

    To me, the popularity of frequentist approaches in the literature means that I see many misapplications and erroneous applications to get that holy p<0.05. Bayesian thinking is not that popular with these people so it's not 't
11. 911.▲
    by a_bonobo 10y ago

    Wow, these p-values are tiny! Fig 1 has heaps of SNPs at -log10 > 50, that's crazy. Could be an effect of their relatively strange decision to use a simple model for GWAS - they used a straightforward linear regression with a more s
12. 912.▲
    by a_bonobo 10y ago

    I don't buy the smoke poisoning angle. They compared with Neandertal AHRs and found that human AHRs may have undergone selective pressures since they're quite different, so the authors tried to connect these changes with the inven
13. 913.▲
    by a_bonobo 10y ago

    I guess it's like newspapers not reporting suicides - it invites copycats, in this case, it creates potential looters
14. 914.▲
    by a_bonobo 10y ago

    Could it be an overhang from the Soviet Union's focus on chess? See for example http://www.slate.com/articles/news_and_politics/explainer/20...
15. 915.▲
    by a_bonobo 10y ago

    What I loved most about Mass Effect was that in its universe, humanity was the new kid on the block, the weirdo completely ignored or mistrusted by all the other species - in the SF I'm used to it's usually mankind who's the
16. 916.▲
    by a_bonobo 10y ago

    I guess because of this: >Since September 9, 2015, the availability of stable grsecurity patches has become limited to the commercial customers of grsecurity.
17. 917.▲
    by a_bonobo 10y ago

    Do you have a source for that? Sounds like a conspiracy theory to me
18. 918.▲
    by a_bonobo 10y ago

    In bioinformatics, awk is such a wonderfully useful tool - most of the data in read alignments/genomics is either in tab delimited format or is easily converted from there (via bedtools, samtools, bamtools etc.), so that it's easy
19. 919.▲
    by a_bonobo 10y ago

    >Sure, everyone is indeed very very friendly and supportive but that can easily be confused with the polite nature that's rooted deeply in this country. Have a look at https://en.wikipedia.org/wiki/Honne_and_tat
20. 920.▲
    by a_bonobo 10y ago

    The link to the doc of the Encyclopedia 404s for me - this link (PDF) works: http://www.dod.mil/dodgc/defense_ethics/dod_oge/eef_complete...
21. 921.▲
    by a_bonobo 10y ago

    Probably negative gearing: https://en.wikipedia.org/wiki/Australian_property_bubble#Inf... Edit, better link: https://en.wikipedia.org/wiki/Negative_gearing#Australia >Interest on an investment
22. 922.▲
    by a_bonobo 10y ago

    Maybe survivor bias? An embryo without mitochondrial/nuclear genes matching up may not survive long enough for a pregnancy to be visible
23. 923.▲
    by a_bonobo 10y ago

    That's true, the Australian system of superannuation is actually pretty great, your job pays a portion of your income into your super which gets invested for you, you have some choice as to where it gets invested (high risk vs. low ris
24. 924.▲
    by a_bonobo 10y ago

    This is a relatively big problem in Australia - there has been talk of a housing bubble in Australia for the last few years which in part has been propped up by Chinese grey money buying whole apartment buildings for investment, which drive
25. 925.▲
    by a_bonobo 10y ago

    Thank you very much! I've bookmarked it. I have to travel to the US again in three weeks, if the problem is still there I'll open a request. Again, thanks!
26. 926.▲
    by a_bonobo 10y ago

    >largely because I can see it operating as a black box and leaving no options for review. Here's a fun story from my experience with the US' immigration system's black box: I'm a citizen of a country that gets ESTA. I
27. 927.▲
    by a_bonobo 10y ago

    Some of my favorites this year: Fiction: - Jude The Obscure, Thomas Hardy. The way Hardy 'smuggles' Jude's viewpoint into the narrative is so ridiculously well crafted, a pleasure to read. - Legend Of The Galactic Heroes - a
28. 928.▲
    by a_bonobo 10y ago

    Then again, we had a baby four months ago and I haven't yet detected any change in personality
29. 929.▲
    by a_bonobo 10y ago

    >Although still analogous to “gambling” tasks used with older samples, the modified version uses varying level of prizes (e.g., poor prize = a single yellow pencil; a great prize = a doll o r nerf toys) instead of the typical monetar
30. 930.▲
    by a_bonobo 10y ago

    I agree with you, the effect size is relatively small, here's the main table: http://www.nature.com/mp/journal/vaop/ncurrent/fig_tab/mp201... Beta is the effect size here, which ranges from 0.0