TheToadKnows

4 ms·

1. 1.▲
   by TheToadKnows 2y ago

   Drug development faces a forecasting problem, not a measurement problem. In the same way that temperature, pressure, and humidity readings have been collected for centuries, it wasn’t until we developed models and computational power that a
2. 2.▲
   by TheToadKnows 3y ago

   I honestly cannot tell if you are trolling now, but I'll oblige one last time. In good faith, I think you might be oversimplifying the situation a bit. The binding of psilocin (or any other ligand) to its receptor is not just about the
3. 3.▲
   by TheToadKnows 3y ago

   Indeed, you're correct in stating that psilocin is dephosphorylated psilocybin, and the core indole structure with the side chain is preserved. However, my point is that psilocybin would never make it to most cells in the body. I sugge
4. 4.▲
   by TheToadKnows 3y ago

   This experimental design is flawed. It's important to remember that orally dosed psilocybin acts as a prodrug for psilocin. It is metabolized into psilocin in the gut before absorbing into circulation. It is psilocin that is primarily