PragmaticPulp

9 ms·

31.
by PragmaticPulp 3y ago
> It’s not much fun. TRT forums are kind of fascinating because they're full of people who though (or, sadly, were convinced by TRT clinics) that TRT was going to be amazing , solve all of their problems, and make them feel like 20
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by PragmaticPulp 3y ago
> You can just dose on HCG for a month and your natural levels will come back. That is the broscience consensus, but it's not as bulletproof as people like to believe. It will probably work for a 25 year old after 1-2 months of dabb
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by PragmaticPulp 3y ago
> You're right though to point out that the body loves homeostasis and will downregulate endogenous testosterone production if serum levels are high from supplementation. Any supplementation will, by definition, raise serum levels h
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by PragmaticPulp 3y ago
TRT is tricky because patients will feel an initial boost in their early treatment. They assume this feeling is their new normal, but then things level out and they go back to a more normal-ish feeling. Severe testosterone deficiencies resp
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by PragmaticPulp 3y ago
Using exogenous testosterone will shut down your endogenous production, or at least permanently reduce it. A lot of people will try to tell you it can be avoided with the right combination of SERMs and HCG, but there are a lot of people who
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by PragmaticPulp 3y ago
> I’m getting more convinced that the best move to improve the likelihood of a successful IPO (which IMHO this whole API clusterfuck is all about) is to fire spez and install a sane CEO. Spez’s PR moves aren’t great, but it’s unrealistic
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by PragmaticPulp 3y ago
> They are valuable only to Reddit for their potential to be monetized. Why are you dismissing this? I don’t understand all of these comments talking about Reddit as if it was 100% free to operate and the only important users are the com
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by PragmaticPulp 3y ago
> It was met with unanimous wtf is wrong with you, go outside. “Go outside” is an ironic comment, given that the subreddit blackout doesn’t appear to be all that popular among casual Reddit users. It’s popular among the chronically onlin
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by PragmaticPulp 3y ago
> The software engineer is one example of a high paying bullshit jobs. Of course, because software has never been useful to anyone.
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by PragmaticPulp 3y ago
> Also important to note that this is an indicator that Reddit has lost all trust from (this part of) the community. Assuming the worst, ignoring details that violate the narrative, and circulating ragebait without verification are all s
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by PragmaticPulp 3y ago
This is basically spamming, but with a time delay so the moderators won’t see it. Worse, the data is already archived by the data collection services. The people who suffer are going to be average users trying to find some answer to a quest
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by PragmaticPulp 3y ago
Or HR/hiring managers spend a few minutes on LinkedIn looking for employees who have 1st or 2nd order connections to the candidate. If someone has been working in an industry for 5-10 years it's not hard to find someone who knows
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by PragmaticPulp 3y ago
People change companies every few years. If a company has 100 engineers and half of them get new jobs after 3 years, you could now have people with 2nd-order connections at 20-50 different companies. Repeat for several cycles and it becomes
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by PragmaticPulp 3y ago
Of the tips in this article, I think this one is simultaneously the most well-known and the most underrated: > Getting a job gets you a professional network, which you can try to turn into a friend network. Getting a job isn't enoug
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by PragmaticPulp 3y ago
> Any substances widely consumed by people should be regulated and tested before they are sold to the public Even after marijuana legalization, many states still have thriving underground marijuana markets. Many people who consume a lot
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by PragmaticPulp 3y ago
Reddit has built a reputation for being "not social media", but in my opinion it has come to embody most of what people say they hate about social media. If I visit Reddit without logging in, the content on the home page is disast
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by PragmaticPulp 3y ago
> You could run a company that sustains itself and its employees, maybe makes a modest profit. Reddit is not profitable, though. They're burning through investment cash just to keep the lights on. That can't last forever, so th
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by PragmaticPulp 3y ago
> So it was always about money. I'm more surprised that anyone thought it wasn't about money. Reddit is a business. An unprofitable business. They have to do something to turn a profit eventually.
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by PragmaticPulp 3y ago
> I like HackerNews because the conversations are mostly intelligent and polite Comment sections like this one highlight the risks of mistaking comments that look intelligent and polite for authority. The number of confident, polite post
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by PragmaticPulp 3y ago
> I wish we stopped treating serotonin as a button that automatically improves mood. We don’t. Studies like this are specifically searching for mechanisms by which serotonin and mood are related. I think you’re projecting the pop-culture
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by PragmaticPulp 3y ago
No, Prucalopride was specifically studied for cardiac complications. Why is there so much rampant misinformation in this comment section when the facts are a simple Google search away?
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by PragmaticPulp 3y ago
> I came to the comment section to mention other seratonergic drugs that do something similar to what the study mentions. Psilocin is a serotonin 2A agonist, LSD is a 1A agonist (according to a quick google search), and this new drug wor
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by PragmaticPulp 3y ago
For anyone coming to this comment section in hopes of understanding this further: This comment section is full of misinformation and discourse about drugs that are completely unrelated to what’s discussed in the article. Serotonin isn’t a s
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by PragmaticPulp 3y ago
> Psychedelics and other serotenergic drugs are becoming the defacto treatment method for a whole host of ailments. They are definitely not. Anecdotes aside, psychedelics are extremely overhyped right now and the downsides are heavily do
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by PragmaticPulp 3y ago
The health podcast industry is making this problem even worse. Many people consume content like Huberman’s podcast and assume he’s an expert because he speaks so confidently and at such lengths. Yet Huberman’s podcasts are well known to con
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by PragmaticPulp 3y ago
> I think all of the "science" of using drugs to treat mental issues is at the level of advancement comparable to medieval blacksmiths doing dentistry. Discounting an entire field of science like this, based on a second-hand ob
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by PragmaticPulp 3y ago
> Perhaps the relevant thing is "household where at least one person makes >100K/yr" since the benefits are probably tied to the type of job. I think you're reading too much into the OP's off-hand guesstimate.
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by PragmaticPulp 3y ago
> 2. Take a break every 45 minutes. Breaks are good when you're having half-day or all-day meetings. For example, when someone has travelled to the office and you're meeting all day. For regular meetings with your normal office
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by PragmaticPulp 3y ago
Also, don’t neglect the role of moderation. I tried browsing, but the top post is a photo of Hitler with the title “A man who did nothing wrong” and several upvotes.
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by PragmaticPulp 3y ago
The reality is hard, but the expectation half of this balance is getting exaggerated: > We could be working 15-hour weeks, enjoying our free time, and living like people of the future. Keynes’ 15-hour workweek essay wasn’t meant to be a

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