NicotineFiend

2 ms·

1. 1.▲
   by NicotineFiend 3y ago

   Many tricyclic antidepressants metabolized by CYP2D6 would be here, if you put the nonmetabolizers up against the rapid metabolizer, https://en.wikipedia.org/wiki/Doxepin for example.
2. 2.▲
   by NicotineFiend 3y ago

   I'm surprised the article didn't mention anything about pharmacogenetics. For example, drug-metabolizing enzyme polymorphisms can often lead to a 10+ fold difference in Cmax (or name the parameter) between a poor and an ultrarapid
3. 3.▲
   by NicotineFiend 3y ago

   https://en.wikipedia.org/wiki/Tree_of_T%C3%A9n%C3%A9r%C3%A9