M_NotableLabs

5 ms·

1. 1.▲
   by M_NotableLabs 12y ago

   Definitely not a stupid question it is really important! There are several novel ways to deliver drugs to tumors in the brain in trials. Some use specially designed pumps, nanotechnology, and intra-arterial delivery (where a catheter is sna
2. 2.▲
   by M_NotableLabs 12y ago

   We arrived at the approach for Notable Labs based on the needs of patients, unfortunately through personal experience. We are not trying to replicate the traditional target, in vitro screening, in vivo studies, and then clinical trials that
3. 3.▲
   by M_NotableLabs 12y ago

   Thanks so much, I consider myself fortunate to have the opportunity to work on a problem that is so personal. It is empowering to go from a passive participant in his care to actively helping others with the disease.
4. 4.▲
   by M_NotableLabs 12y ago

   1. Could you clarify your question on this please? We won't be replacing the pathologist report for the oncologist. We also don't obtain the tumor after their analysis and report. Our testing will be running in parallel. We produc
5. 5.▲
   by M_NotableLabs 12y ago

   Thanks! 1. There are indeed similar efforts in academic labs around the world. The constraint they face is lack of funding to expand their experiments beyond testing drugs on their small sized tumor banks. Industry labs don't generally
6. 6.▲
   by M_NotableLabs 12y ago

   This is a really great point srunni thank you for bringing it up. We agree that the current approach to identifying predictive cancer biomarkers has many challenges. That's why we believe in a different approach. Glioblastoma was actua
7. 7.▲
   by M_NotableLabs 12y ago

   Thanks for your questions! Yes we'll be testing combinations, as this brain cancer has not responded historically to single agent therapy for decades. With combinations of existing drugs it is possible to affect multiple driver pathway
8. 8.▲
   by M_NotableLabs 12y ago

   Very cool! I'd love to follow up with you if you'd be interested, imaging is a major problem in this disease. 1. Great question, this is why we'll be focused on newly diagnosed glioblastoma patients. If they do recur and have
9. 9.▲
   by M_NotableLabs 12y ago

   - This is one of the reasons we have started with Glioblastoma Multiforme (grade 4 brain cancer), as it has been grown in serum free suspension cultures (the neurosphere assay) by many labs for the past decade or so. When we eventually look
10. 10.▲
    by M_NotableLabs 12y ago

    Thanks for your questions! We are testing both cancer and non-cancer drugs. 1. We agree, the reason we are using cell culture is because it is very fast and allows us to test many combinations at once. We have improved standard cell cultur
11. 11.▲
    by M_NotableLabs 12y ago

    Hi I'm Matt, one of the founders of Notable Labs. Here are more specifics on our process: Step 1: The patient undergoes surgery to remove their brain tumor, which is sent to our lab where the cells are grown. Step 2: We use lab roboti