KempyKolibri

8 ms·

31.
by KempyKolibri 8mo ago
There’s a good pod on this exact subject with nutrition scientists: https://sigmanutrition.com/episode538/ The TL;DR (IIRC) is that we tend to only see this in trials where atrial fib is a tertiary endpoint so there’s
32.
by KempyKolibri 9mo ago
There’s essentially no evidence that the degree of ultraprocessing affects a food’s healthfulness. There are tenuous and broad associations between UPF content of a diet and health outcomes, but these are based on invalidated FFQs for the e
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by KempyKolibri 9mo ago
Yeah, IMO there’s a continuum between lean meats that I’d classify as relatively middle-of-the-road healthwise (like chicken), and processed red meat (pretty adverse health outcomes even from small amounts), and the fact that there’s a “but
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by KempyKolibri 9mo ago
UPF meat substitutes do tend to be healthier than their meat-based equivalent (see the SWAP-MEAT trial, for example).
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by KempyKolibri 9mo ago
Eating mostly plants does not mean one has to have protein deficiency. Seitan, tofu, tempeh, TVP, etc etc. All plant based, all high protein.
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by KempyKolibri 9mo ago
Fair point! I’m not that woke on the relative health impacts of vaping but agree that the positive impact of vaping is not akin to that of actual food, no matter how processed.
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by KempyKolibri 9mo ago
By heuristic, I just mean “a rule used in decision making”. Under that usage, the fact that the rule doesn’t provide fine-grained advice doesn’t disqualify it from being a heuristic. Eating mostly plants is a rule used in decision making wh
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by KempyKolibri 9mo ago
It's just a dietary heuristic, why would it have to explain everything? If you want that, just go and look at the literature on overweight and obesity or, say, substitution of animal protein for plant protein. It's all there.
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by KempyKolibri 9mo ago
This area is very interesting and lots of this is on the money. That said, I think there are some places where it overreaches and possibly verges on fear mongering based on pretty weak evidence. I'm not sure NSS are necessarily "h
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by KempyKolibri 9mo ago
No, because we have a huge body of evidence pointing to both the safety and efficacy of lipid lowering medications. We know that as far as LDL-c goes, the lower the better, so since we have safe drugs that lower more effectively than lifest
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by KempyKolibri 9mo ago
What’s the evidence that lifestyle intervention is more effective than combination medication therapy?
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by KempyKolibri 9mo ago
Because medication is more effective. Side effects from statins are relatively uncommon and generally mild, so it wouldn’t be ethical to use lifestyle as a first-line treatment in place of, say, a combination of low dose statin and pcsk9 in
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by KempyKolibri 9mo ago
Feels a bit like this though, no? https://xkcd.com/2557/ The reason we want people to get vaccinated is to stop people getting the diseases…
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by KempyKolibri 9mo ago
Triggered mine too, especially “Modern JavaScript applications aren't just a few scripts anymore — they're sprawling codebases”
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by KempyKolibri 10mo ago
I wasn’t aware of that critique, thanks for sharing. Before I read the response my first thought was “why such consistency across different SNPs, then?”, so I would certainly agree with that aspect of the defence. In general, Ference’s expl
46.
by KempyKolibri 10mo ago
> I thought that was basic enough that I didn't need to explain it. But here goes... This is quite the tone to take when the actual point being made has demonstrably sailed over your head, considering the reference provided to you e
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by KempyKolibri 10mo ago
Graboy has provided the citation I would have given, as well as an excellent explanation. I’m not sure what you mean by “heart disease is clearly not Mendelian”.
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by KempyKolibri 10mo ago
Yep - the SAMSON trial suggests that nearly all side effects attributed to statins are actually just nocebo: https://www.jacc.org/doi/10.1016/j.jacc.2021.07.022
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by KempyKolibri 10mo ago
The band aid analogy doesn’t make sense when we consider the MR studies showing the lower your genetically determined LDL-c, the lower your risk of CVD. If everything was randomised except the number of band aids, why would having fewer ban
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by KempyKolibri 10mo ago
Why do we see consistent dose response between LDL lowering SNPs and cardiovascular disease in Mendelian randomisation studies, then?
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by KempyKolibri 10mo ago
If “highest number of n=1 studies wins” is your yardstick for causal inference then you’re part of the reason the keto crowd isn’t taken seriously. Wish I could sugar coat it more but that’s the reality, and I think some people on that side
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by KempyKolibri 10mo ago
We have some case studies and pilot studies without any kind of control. Perhaps keto/low carb could be helpful (it certainly is with epilepsy!), but I certainly haven’t seen any evidence that it’s superior to other diets that achieve
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by KempyKolibri 10mo ago
> A "very high evidence bar" that isn't described anywhere is one that doesn't actually exist If your claim is: “if a standard isn’t explicitly written down somewhere such that one can utilise it to ascertain whether
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by KempyKolibri 10mo ago
> A lot of the COVID pseudo-science was specifically designed to manipulate people's emotions (e.g. journals rejecting correct papers because fewer people might take vaccines as a result [1]). 1. What Covid pseudo science are you re
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by KempyKolibri 1y ago
jjui is amazing, sometimes I feel like I shouldn't rely on it so much so I learn the CLI, but it's just so useful!
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by KempyKolibri 1y ago
The evidence base on eggs is a funny one because of: 1. Genetic traits influencing response to dietary cholesterol. 2. The effect of baseline dietary cholesterol on the impact of additional dietary cholesterol (if you're already consum
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by KempyKolibri 1y ago
> In the same way that increased salt intake causes increased water retention, and thus increased weight, but this increased level of water weight goes away after a few days if you start consuming less salt, and there's no evidence
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by KempyKolibri 1y ago
Monkey nut paste and big hairy ball juice, obviously.
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by KempyKolibri 1y ago
Sorry, I summarised what I thought was your goalpost earlier in the exact same words and you didn’t correct me, so I made the assumption in subsequent replies. I’m not interested in straw manning your argument, just trying to understand. I’
60.
by KempyKolibri 1y ago
You said: > if you'd picked a slightly different set of CVD-correlated biomarkers you would have got exactly the opposite result. So the evidence I’m looking for is empirics showing CVD correlated biomarkers that suggest a beneficia

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