Fusionnex

4 ms·

1. 1.▲
   by Fusionnex 4y ago

   I like the contrast between descriptive vs generative here. Really puts this into context. If you want to understand the contribution of any particular allele PGS is reasonable. But using PGS to generate a phenotype violates so many assumpt
2. 2.▲
   by Fusionnex 4y ago

   I really like the food analogy here. This is a perfect explanation for why embryo selection using this method would absolutely fail. Polygenic scores are touted as this magic bullet for understanding the contribution of genetics to a phenot
3. 3.▲
   by Fusionnex 8y ago

   Assuming I remember correctly. It takes only six individuals with the right breeding scheme to maintain a reasonable level of diversity. This is of course assuming that enough diversity is present in the founding population (ie the frozen s