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DrAwdeOccarim
searching PlanetScale…
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61.
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DrAwdeOccarim
4y ago
This is a great reply because it shows just how much things are about to change. OP is likely a smart, digitally inclined individual and they missed this use case. This will sweep through the general population eventually so lean in and lea
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DrAwdeOccarim
4y ago
I have one, it works, but I really want to connect it to a pi for data logging and visualization but I don’t have the time to code it up. If you go down this road, please let me know if you wind up finding a good open source project for man
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DrAwdeOccarim
4y ago
Yea, humans are unable to mentally understand deep time or small scales. We think way too linearly. Glad it made sense!
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DrAwdeOccarim
4y ago
You've got the idea! I'm not an HIV biologist, but typically these viruses utilize poly-cistronic transcripts. What that means is the proteins are made off the same mRNA so when they come off the ribosome they are local to the pre
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DrAwdeOccarim
4y ago
Totally! Thanks for the suggestion : )
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DrAwdeOccarim
4y ago
Totally! I got my tech back in the '10s and just got my general a few months ago. The coolest tinkering part is the antenna. So much cool physics and mental imaging of emission patterns based on the length and frequency you want to bro
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DrAwdeOccarim
4y ago
Moderna | Entry Level PhD (Scientist) or 1-2y for Sr. Sci | Full-time ONSITE | Cambridge, MA | https://modernatx.eightfold.ai/careers/?pid=309250885374 I am looking for someone with phosphoramidite-based oligo synthsis
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DrAwdeOccarim
4y ago
Ctrl-F for "waste" only turned up your comment. Waste management of all the experiments the article describes had me wincing as an industrial chemist. I'd say it's not so much the safety of home chemistry that keeps me a
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DrAwdeOccarim
4y ago
For those who are just first learning about click chemistry, it makes attaching two larger molecules together very, very simple. It can be done under very gentle conditions (like in water), and has exceptional selectivity. Like it's so
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College was necessary for me. Will my own child need it like I did?
(salon.com)
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DrAwdeOccarim
4y ago
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DrAwdeOccarim
4y ago
To follow on, typically proteins produced this way have a tag, or handle, to specifically pull it out from all the other proteins. A typica tag is 6 x Histidine amino acids at the beginning of the protein. These histidines bind to nickel, w
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DrAwdeOccarim
4y ago
Again, not to further inflame, but no corners were cut for the trials. The only thing that happened was the Federal government covered the costs to do all parts in parallel (for Moderna, kinda also for Pfizer with the APA, but more complex)
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DrAwdeOccarim
4y ago
I can totally relate! Asking the basic premise questions, for me at least, is what allows the more complex parts of presentations to click into place. Like it all just sits in the buffer, percolating, recombining, and I just need that seed
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DrAwdeOccarim
4y ago
That is super lucky! I was fortunate they were super academically supportive, but psychologically? Terrible. Same with my post-doc advisor, though the rest of the lab members were really the academically supporting part of my post-doc; my a
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DrAwdeOccarim
4y ago
I wonder if avoiding the wires has anything to do with magnetic field lines? I know some birds can see the earth's magnetic field, maybe the wires appear larger to their magnetic senses compared to other bird species?
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DrAwdeOccarim
5y ago
Of course these types of articles were bound to come out, but part of why Karikó and others like her are successful is because they did not get showered with funds and success. The grit is part of the recipe. It reminds me of Alex Danco
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DrAwdeOccarim
5y ago
Yea, totally. I remember downloading my first picture of a naked lady from a BBS me and my friend had found. It was a single playboy centerfold that took 20-30 minutes to download. I distinctly recall us turning the monitor off to let it do
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DrAwdeOccarim
5y ago
I'm so sorry you're having such a hard time hearing and dealing with all this BS. Sending a firm but warm internet handshake your way. I don't have an answer to your issues and am here to listen if you need someone to vent to
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DrAwdeOccarim
5y ago
Yea, that’s a good one!
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DrAwdeOccarim
5y ago
I don’t sense hostility outside the typical vocal minority. Having straddled the FDA-regulated world and the libertarian-leaning internet cultures through the aughts and teens, my experience is that the internet libertarians are simply igno
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DrAwdeOccarim
5y ago
I know I'm not supposed to comment when it doesn't add to the conversation, buuuut, your reply made me literally laugh out loud. Thank you for this! I often forget being ~40 means I'm no longer ~20 and that there are people w
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DrAwdeOccarim
5y ago
Commenting to save; this is prime advice right here.
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DrAwdeOccarim
5y ago
We used to have a monthly computer show and sale in the DC area. It was like this but in tents at the fair grounds. It was heaven. What an incredible time to come of age alongside modern technology coming of age. I still have bins of comput
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DrAwdeOccarim
5y ago
I started my chem grad school about a decade later and all the changes were well accepted and the field was still mourning her loss. What a tragedy.
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DrAwdeOccarim
5y ago
Someone should make this a movie.
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DrAwdeOccarim
5y ago
I doubt it. All disposed of according to hazardous waste rules. Also, large study animals are so important that most tissues and bits are studied during necropsy in close details with retained material kept frozen for years.
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DrAwdeOccarim
5y ago
You can’t really. You test in naive animals when critical, but repeating an experiment or needing a quick binary read-out, you can use non-naive successfully.
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DrAwdeOccarim
5y ago
I think my point was lost in the deep analogy : ) The patents are the recipe. It’s not going to work if you just share the recipe.
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DrAwdeOccarim
5y ago
I think the best way to describe the situation is akin to cooking. Imagine the best chef in the world, Michelin stars and all. Would a written recipe of a 10 course meal result in the same final product? How about a video of the full prepar
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DrAwdeOccarim
5y ago
Yes. The ‘platform’ is like a notebook in a ziplock bag. Write the code for $VACCINE in the notebook, place it in the bag, give it to a person. Very interchangeable. Source: I work in the field.
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