Clostridium

5 ms·

1. 1.▲
   by Clostridium 5y ago

   Sigh. Phase IV trials are not part of the approval process; they follow formal FDA or EDA approval and noone is doubting they are important. Regarding risky: it is a well managed risk, and one that you simply cannot not take in the fa
2. 2.▲
   by Clostridium 5y ago

   Phase IV trials are only undertaken after formal approval by FDA and EDA; they are not relevant in the current context. The current vaccins (including Pfizer, moderna which clearly use a novel mechanism for delivery) also don't have ph
3. 3.▲
   by Clostridium 5y ago

   Not true, the genome of viruses is very variable/evolvable due to its high mutation rates.
4. 4.▲
   by Clostridium 5y ago

   There are always risks, and ignoring a novel approach is also a risk. The issue is to gauge risk intelligently, based on extensive prior medical, biological and physicochemical knowledge and modelling, and on sound clinical testing using ra
5. 5.▲
   by Clostridium 5y ago

   Corona virus exploiting frame shifting using a pseudoknot is not a at all unproven, has been known and researched since 2005
6. 6.▲
   by Clostridium 5y ago

   Au contraire, this is exactly the thing that we should look into in an emergency! RNA-slippage is a well-known mechanism that a healthy cell has safeguards against. The corona virus exploits this slippage, so disabling it using a drug is