COGlory

52 ms·

631.
by COGlory 4y ago
Depends. A random metallo-organic compound vs a random protein? Yes. But the problem can be further up the chain. Synthesis can be expensive and difficult, and you need a relatively large crystal (at least for X-ray). If you have low symmet
632.
by COGlory 4y ago
Here is a link to some commentary on the ABC transporter debacle. http://xray0.princeton.edu/~phil/Facility/Guides/ABCtranspor... I'm not 100% sold that it was malicious, but imo that doesn't change
633.
by COGlory 4y ago
Raleigh's criterion says hydrogens should be just on the cusp, at least with home source xrays. Not sure about synchotron.
634.
by COGlory 4y ago
Because it's being presented as something that it isn't. It's a better way to analyze data that we got experimentally, and to predict how new data will fit into what we know. It's not de novo understanding, which is the
635.
by COGlory 4y ago
MKVLMKKESLPIVKPFDEVIIEVLQAPKEVEREVALKDGTIKKIQDYSIIVKPVSGKFESVTEKVTSKTEDGDEVVKPKKYDASELKDKVVMKLTQKAFEVLYDAWQNKEIGEGTKLKIKVTKKQNKTYFDEITVLDEKEEEETEEEAKVKPKPKLKG
636.
by COGlory 4y ago
>Domains with novel folds usually have a low number of remotely homolog sequences and for that reason the method will fail, not just because they are novel. How can you say this but not believe it's doing homology modeling?
637.
by COGlory 4y ago
>I would like to correct somethign here- it does predict structures de novo and predict folds that haven't been seen before. That's because of the design of the NN- it uses sequence information to create structural constraints.
638.
by COGlory 4y ago
Perhaps you'd care to explain how? AlphaFold does not work on new folds. It ultimately relies on mapping sequence to structure. It does it better than anyone else, and in ways a human probably couldn't, but if you give it a brand
639.
by COGlory 4y ago
It's all about boosting signal by finding other proteins that are similar, until you get to the point that you can identify a fold to assign to a region of the protein. That's why some are structural, and some are not. >Further
640.
by COGlory 4y ago
> Not sure if you should be reminded of how alpha fold started, it started by winning a competition thought un winnable by academics. Top labs working in protein structure prediction have fundamentally changed direction after alpha fold
641.
by COGlory 4y ago
AlphaFold figures out that my input sequence (which has no structural data) is similar to this other protein that has structural data. Or maybe different parts of different proteins. It does this extremely well.
642.
by COGlory 4y ago
It has template structures. AlphaFold uses the following databases: BFD, MGnify, PDB70, PDB (structures in the mmCIF format), PDB seqres – only for AlphaFold-Multimer, Uniclust30, UniProt – only for AlphaFold-M
643.
by COGlory 4y ago
1) Isonet - takes low SNR cryo-electron tomography images (that are extremely dose limited, so just incredibly blurry and frequently useless) and does two things: * Deconvolutes some image aberrations and "de-noises" the images *
644.
by COGlory 4y ago
Before my comment gets dismissed, I will disclaim I am a professional structural biologist that works in this field every day. These threads are always the same: lots of comments about protein folding, how amazing DeepMind is, how AlphaFold
645.
by COGlory 4y ago
It was pre-mined. That is the very definition of shady.
646.
by COGlory 4y ago
Signal always left a bad taste in my mouth. It's fundamentally built on the requirement that to have conversations with any trusted individual, I need to, for no obvious reason, also incorporate and trust a 3rd party individual, who wo
647.
by COGlory 4y ago
Quit the weed.
648.
by COGlory 4y ago
They aren't mutually exclusive.
649.
by COGlory 4y ago
You have missed the essential argument: The claim is that "someone ELSE's life begins at conception". Obviously all cells are alive, but they are your own until they become a new human being. Once that new human being is crea
650.
by COGlory 4y ago
I hadn't considered this angle, and would love to be wrong, but haven't digital books been exempt from first sale doctrine for quite some time now? I thought this case law was well established.
651.
by COGlory 4y ago
So...they didn't think the law should apply so they just decided to ignore it? What were they expecting? How can they possibly expect to win this lawsuit? I hate copyright with all my soul but this is just stupid. You can't just d
652.
by COGlory 4y ago
How much power is regenerated though? Theoretically, electric vehicles shouldn't have to store quite as much energy.
653.
by COGlory 4y ago
This sounds like FoldIt?
654.
by COGlory 4y ago
What does that have to do with this topic?
655.
by COGlory 4y ago
Little late for that if you already bought it.
656.
by COGlory 4y ago
600,000 immediate American casualties (not to mention the slaves) is not a great example here, of something being "simple"
657.
by COGlory 4y ago
That figure is simple supply and demand. It shows supply staying roughly steady, and demand increasing drastically every year. Climate has nothing to do with that calculation (although it's possible it's exacerbating it, this was
658.
by COGlory 4y ago
I'm not sure about med school, but grad schools are notoriously flexible. Send an email to the biochem program and ask.
659.
by COGlory 4y ago
Disclaimer: I'm not a dietitian, although I do have a B.S. in Nutritional Science with a didactic focus. What you are describing has all the hallmarks of a psychological condition (eating disorder) and not a physical condition (poor di
660.
by COGlory 4y ago
Those are interesting analogies, particularly for the RNA. Thanks for sharing them.

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