100ideas

8 ms·

31.
by 100ideas 6y ago
Well, the government has spent billions paying Boeing et al to develop a (non-reusable) public option, Orion, but it has had multiple problems (thanks, Boeing!). So if they are publicly endorsing SpaceX, that’s a serious rebuke to the publi
32.
by 100ideas 6y ago
Someone should price this out on transcript aka https://strateos.com/ cloud lab...
33.
Steward-ownership is capitalism 2.0(medium.com)
2 points by 100ideas 6y ago|0 comments
34.
by 100ideas 6y ago
article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7507405/ some quotes: "Consider for example, the arrangement of iron filings sprinkled over a magnet. A conventional computer could calculate their c
35.
by 100ideas 6y ago
The infographic ranks the pandemics by total deaths, but "deadlyness" should be compared by normalizing against global population I think. After some searching I found https://en.wikipedia.org/wiki/Estimates_o
36.
by 100ideas 6y ago
I’m going to take an extreme position in the hopes it “stimulates” conversation: the best course is $6k direct citizen payments. Business that fail create new niches some of the gritty but solvent ex-employed can try to exploit with new sta
37.
by 100ideas 6y ago
On the eve of passing the first $2 trillion stimulus package, final deliberations in the US Congress about the "best" way to use the funds devolve into partisan deadlock: One side insists that the only rational policy is for appro
38.
by 100ideas 6y ago
100%
39.
by 100ideas 6y ago
For those out there interested in DIY molecular diagnostics, in addition to qPCR, also check out this new technique: "SHERLOCK-based one-step test provides rapid and sensitive COVID-19 detection: New CRISPR-based research tool delivers
40.
by 100ideas 6y ago
No no, thank YOU for "refuting" my "refutation"! I do stand corrected, I did not internalize your "total antibody-based immunity will last a few years" sentance, and was focused on the following "memory B
41.
by 100ideas 6y ago
It's estimated that ~14% of common cold cases are caused by coronaviruses (HCoV-OC43, HCoV-229E, HCoV-NL63)... so although it seems particularly difficult, if we do manage to discover how to develop effective vaccines against Covid19,
42.
by 100ideas 6y ago
What’s your approach for getting covid19 template dna for the positive control reaction?
43.
by 100ideas 6y ago
Just to spell it out: herd immunity depends on sustained immunity postinfection. It seems possible, perhaps probable, that covid19 "immunity" may have an unusually short duration or attenuated response, resulting in an effective h
44.
by 100ideas 6y ago
As @tpnCC and @seppin said, there is significant clinical & scientific uncertainty about covid19 antibody response and duration, partly because there hasn't been enough time to collect the relevant data (for covid19) and partly bec
45.
by 100ideas 6y ago
Here's the reference: Liu 2020 "Anti-spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection." https://doi.org/10.1172/jci.insight.123158 here are my hig
46.
by 100ideas 6y ago
Correct - there was a long-term memory T cell response. However, see sentance immediately preceeding the one you quoted - basically SARS-CoV IgG antibodies ("IgG Ab" below) were totally absent 6 years after infection. So, antibodi
47.
by 100ideas 6y ago
Furthermore it seems as if mutations to the spike gene unique to hCov-2019 somehow is involved in suppression of immune systems’ ability to properly regulate its inflammation response; specifically, it seems to mess with the correct functio
48.
by 100ideas 6y ago
Your personal belief about medium-to-long-term immunity is contradicted by research on same with SARS; see “Lack of Peripheral Memory B Cell Responses in Recovered Patients with Severe Acute Respiratory Syndrome: A Six-Year Follow-Up Study&
49.
by 100ideas 7y ago
Some friends recently pointed me at: https://covidbase.com/
50.
Potential interventions for novel coronavirus in China: A systematic review(onlinelibrary.wiley.com)
2 points by 100ideas 7y ago|0 comments
51.
by 100ideas 7y ago
the following article, published 13 Feb 2020, provides an exhaustive list of potential covid19 therapeutics, including remdesivir and a variety of other antivirals. Zhang, L, Liu, Y. Potential interventions for novel coronavirus in China: A
52.
by 100ideas 7y ago
Very cool article summarizing potential of remdesivir as potential therapeutic vs Covid19. Submitted 16-Feb-2020, published 6-Mar-2020, and as of today 15-Mar-2020, it is the third-most-recently published article about remdesivir vs covid19
53.
by 100ideas 7y ago
You might find io-ts useful [1]. “io-ts introduces the concept of a runtime type (an instance of the Type class) which represents a runtime validator for a typescript (static) type. [2]” See: [1] https://gcanti.github.io/i
54.
by 100ideas 7y ago
Are there phage therapy options for persistant lyme disease? Lyme disease is caused by the pathogen Borrelia burgdorferi. A quick pubmed search ([1],[2]) turned up two papers describing phage that interact with Borrelia. Neither discussed t
55.
by 100ideas 7y ago
Let’s talk virtual particles...
56.
by 100ideas 7y ago
The universe appears to have expanded or be expanding faster than the speed of light: the diameter of the observable universe is ~42 billion light-years but best estimates of age of universe is ~14 billion years. So these fields can’t inter
57.
by 100ideas 7y ago
What, you don’t think the Hylaean Theoric World is realer that reality?
58.
by 100ideas 7y ago
How does spacetime know to curve?
59.
by 100ideas 7y ago
Ok, thanks for bringing precision to my comment. It makes sense that any photons reaching an observer who is inside a BH event horizon must also already be trapped inside the EH. I think what I find confusing is that I thought outside obser
60.
by 100ideas 7y ago
I like your elegant thought experiment! Quarks have -1/3 or +2/3 charge in the standard model and presumably(?) at high enough energies they separate out into a quark-gluon plasma thus exposing the universe to their unholy fractio

More ›