0xB31B1B

18 ms·

151.
by 0xB31B1B 4y ago
I mean, if you have perfect bloodwork and a marvel movie body probably not necessary but otherwise yes. Heart disease, hypertension, high cholesterol, colon cancer rates are rising amongst everyone, even thin people. These drugs positively
152.
by 0xB31B1B 4y ago
Trizepatide, brand name is mounjaro. It’s a similar drug to semaglutide.
153.
by 0xB31B1B 4y ago
These drugs modulate your hormones to reduce appetite and cravings for unhealthy foods. When people lose weight the normal way, their endocrine system sends out a “you are starving, eat” hormone response that is extremely difficult to overc
154.
by 0xB31B1B 4y ago
I’m currently taking one of these drugs and it has been no less than a miracle in my life. I became obese when I was around 5, topping out around a 34 BMI. When I was 20 I lost a substantial amount of weight the old fashioned way (diet and
155.
by 0xB31B1B 4y ago
Google is hamstrung by their AI ethics teams who don’t allow ground breaking things to be shipped.
156.
by 0xB31B1B 4y ago
He’s talking about web3. This is the idea of soul bound tokens. It can and should be independent of web3, but the problem is that web3 companies have taken in 5-10b of institutional funding, they have zero users and zero PMF, and they need
157.
by 0xB31B1B 4y ago
Users and pumpers are not the same. The most successful web3 project (helium) is a horrible failure. No one using the network, node owners being paid Pennie’s per month, and the whole product/company could have been tested and develope
158.
by 0xB31B1B 4y ago
The valuable use cases are capital controls evasion, tax evasion, remittances to Argentina, KYC evasion, money laundering. It is truly and only a pirate currency use case. There is no dapp/smart contract/DAO construct that is fund
159.
by 0xB31B1B 4y ago
There is no PMF in anything web3 related. Web3 is a mountain of trash. Token economics is a rebranding of ponzi economics. Really can't take seriously the investors who made a quick buck flipping trash coins and still talk their book.
160.
by 0xB31B1B 4y ago
Its a lot easier to manage dev envs if everyone is literally using cloned ec2 instances that can be remotely fixed/managed by devexp teams. These type of projects are a big step forward IMO
161.
by 0xB31B1B 4y ago
This isn't whats happening at all, at least in ag. There is a huge amount of deadweight loss to extremely wealthy long time ag landlords who own water rights. At this time, they have extremely inefficient water uses because water is co
162.
by 0xB31B1B 4y ago
a huge portion of the alfalfa being irrigated isn't even used to feed american beef. The plants are literally sent to saudi arabia to feed cows there. You could entirely fix the agricultural use of water if you priced it more accuratel
163.
by 0xB31B1B 4y ago
Academic lawyers (his parents) are nothing like trial lawyers. Don’t expect them to have a good poker face.
164.
by 0xB31B1B 4y ago
100% There is a lot of value in ransomware, the ability to purchase drugs, and money laundering.
165.
by 0xB31B1B 4y ago
5.x earthquakes are not “stress relievers”, that is a common fallacy.
166.
by 0xB31B1B 4y ago
1) cut 35% of engineering team, including all L4s and L3s, and people who have scored 2/5 or lower on perf reviews 2) Cut 100% of marketing team, Elon is marketing team now. 3) Cut 100% of policy team. Elon is policy team now 4) Cut 80
167.
by 0xB31B1B 4y ago
You scope the deliverable to the level of the person you’re hiring, but at the end of the day I do want to hire people who have actually really done something, not just people with the potential to do something. There is nothing wrong with
168.
by 0xB31B1B 4y ago
They don't turn them away because "they don't know how to operate on them" they turn them away because many surgical procedures on obese patients are well studied to have negative outcomes and risks for obese patients th
169.
by 0xB31B1B 4y ago
You can't perfectly judge someone in an interview context, but you can get pretty good if you ask the right questions with the right structure. Where I work the final round interview we give the candidates a week to write a design doc
170.
by 0xB31B1B 4y ago
There are absolutely ways to measure the performance of an individual. That leetcode style questions are not a great indicator of ability to do the job well does not mean you cannot predict job performance at all.
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by 0xB31B1B 4y ago
This is good. Also would like max 85mph speed governors and tighter limits on car dimensions to limit the massive truck hood heights
172.
by 0xB31B1B 4y ago
My biggest suggestion to anyone looking down this path is, in addition to your normal SWE responsibilities, really understand production engineering concepts (testing, reliability, alerting, monitoring, running an on call rotation, capacity
173.
by 0xB31B1B 4y ago
To be fair, in the 70s it was much harder to be productive as an engineer. You weren't writing javascript, you were writing fotran, or cobol, or assembly code, or C. Everything was much less "standard" than it was today, from
174.
by 0xB31B1B 4y ago
To be more precise, my problem with this study is when you select for people with BMI>30 and filter for those who do not have obesity related health issues, you’re going to have a lot more of the pathological case, like body builders, ta
175.
by 0xB31B1B 4y ago
My argument is that in 2022, the medical advise and consultation of “diet and weight loss is the solution to obesity” is not true on a population level. We now have other tools to address obesity that are both pharmacological (GLP-1/GI
176.
by 0xB31B1B 4y ago
182 cm isn't even that tall. I'm 193 CM and athletic build and at my recommended weight range by body composition measurements had me at like 26 BMI or "overweight".
177.
by 0xB31B1B 4y ago
Substantial weight loss is possible across a range of treatment modalities, but long-term sustenance of lost weight is much more challenging, and weight regain is typical1–3. In a meta-analysis of 29 long-term weight loss studies, more than
178.
by 0xB31B1B 4y ago
Substantial weight loss is possible across a range of treatment modalities, but long-term sustenance of lost weight is much more challenging, and weight regain is typical1–3. In a meta-analysis of 29 long-term weight loss studies, more than
179.
by 0xB31B1B 4y ago
There are many double blind studies on this. On a 2+ year time horizon, the huge majority of obese people who follow a "eat less exercise more" regime lose weight and then gain it back. This happens because the people never stop b
180.
by 0xB31B1B 4y ago
"The fix is diet and exercise" is not correct at all. There is no evidence on population level data or studies that diet and exercise produce durable BMI loss on a population level. From a "calories in calories out" pers

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