4 ms·

I knew someone once who'd used heroin for a while and gave it up and he told a similar story. He said it "makes the pain go away," and I asked what he meant and

by api 12y ago

I knew someone once who'd used heroin for a while and gave it up and he told a similar story. He said it "makes the pain go away," and I asked what he meant and he just said "all of it" and smiled. He said I'm in horrible, horrible pain and have no idea because I'd never tried heroin before. :O Immediately made me think of this great old sci-fi story: http://bestsciencefictionstories.com/2009/05/17/desertion-by-clifford-d-simak/ http://bestsciencefictionstories.com/2009/05/17/desertion-by...

chrisBob 12y ago
My wife said something similar about morphine: "Did you know your hand hurts really bad while you are just standing there right now? You have no idea until you have morphine and it gets instantly better."
- SapphireSun 12y ago
  That's really interesting. I imagine nociceptors have a baseline firing rate but your brain tunes it out because it's just noise. If you switch that off, the current filter system would get whacked out of balance, you'd feel awesome, but when it switches on again, baseline firing would be a salient input for a bit and you might notice it? Of course, long term up/down regulation of various receptors occurs too, but I've never heard of this particular effect before though it sounds plausible to me.
  - api 12y ago
    I wondered a while back if (theoretically) taking some kind of non-harmful but pain stimulating compound might not make you feel awesome the rest of the time, and might even be good for you by recalibrating your inflammatory response and such.
    - nvader 12y ago
      See: spicy food.
      - api 12y ago
        I was thinking of something more systemic, but that may be an example.
    - sjf 12y ago
      BDSM has been shown to improve mental health in a number of ways. http://onlinelibrary.wiley.com/doi/10.1111/jsm.12192/abstract http://onlinelibrary.wiley.com/doi/10.1111/jsm.12192/abstrac...
  - xanderstrike 12y ago
    If you've ever wondered why people on hard drugs like to take off their clothes when they're coming down, this is it. You can't handle the sensory overload of your t-shirt against your skin.
    - MichaelGG 12y ago
      Hard drugs isn't a category of drugs, but powerful opiates seem to be what's included anyways. I'm not aware of opiate users habitually taking off clothing. Other powerful drugs can make you feel cold, adding clothing. Some people really sweat on acid, which is probably a decent cause of taking off clothing.
ufmace 12y ago
I remember talking to somebody in the medical industry once. I don't remember exactly what his job was, but he told me that he had done some work with opiate addicts. Supposedly, their brains themselves can get so powerfully addicted to the drugs that it actually generates phantom pain in order to force the user to get more opiates to make it go away. Every test they can run shows that the addict is actually feeling real pain, but there is absolutely nothing physically wrong to cause it. The idea that the brain can work on that level, actually causing artificial sensations to trick our conscious mind, is both amazing and scary.
- MichaelGG 12y ago
  Forget physical pain. Opiates make the mental pain, the pain of existence go away. Stress, business problems, finances, it's all manageable with opiates. Most people don't know just how much better human existence can be with a bit of tweaking to our chemistry. We accept we're no longer in our ancestral environment, why can't we accept that our default chemistry is suboptimal?
  - stefantalpalaru 12y ago
    Suboptimal in what way? We create, develop, improve because we are unsatisfied, not because we are happy.
    - MichaelGG 12y ago
      I don't think that's accurate. Certainly some people work jobs just to get cash to pay bills. But plenty of people create for the fun of it. Our brains operate suboptimal because we can not control their state. We get worried when it provides no benefit. We get sad and troubled when we shouldn't. We experience intense pain with no way to shut it off. We lose focus, even when we really want to concentrate. Everyone should have the capability and choice of modifying their brain chemistry on demand. Your premise that people should be forced to be unnecessarily unsatisfied because some of them might go on to do great things is cruel.
      - 12y ago

by api 12y ago

chrisBob 12y ago

My wife said something similar about morphine: "Did you know your hand hurts really bad while you are just standing there right now? You have no idea until you have morphine and it gets instantly better."

SapphireSun 12y ago
That's really interesting. I imagine nociceptors have a baseline firing rate but your brain tunes it out because it's just noise. If you switch that off, the current filter system would get whacked out of balance, you'd feel awesome, but when it switches on again, baseline firing would be a salient input for a bit and you might notice it? Of course, long term up/down regulation of various receptors occurs too, but I've never heard of this particular effect before though it sounds plausible to me.
- api 12y ago
  I wondered a while back if (theoretically) taking some kind of non-harmful but pain stimulating compound might not make you feel awesome the rest of the time, and might even be good for you by recalibrating your inflammatory response and such.
  - nvader 12y ago
    See: spicy food.
    - api 12y ago
      I was thinking of something more systemic, but that may be an example.
  - sjf 12y ago
    BDSM has been shown to improve mental health in a number of ways. http://onlinelibrary.wiley.com/doi/10.1111/jsm.12192/abstract http://onlinelibrary.wiley.com/doi/10.1111/jsm.12192/abstrac...
- xanderstrike 12y ago
  If you've ever wondered why people on hard drugs like to take off their clothes when they're coming down, this is it. You can't handle the sensory overload of your t-shirt against your skin.
  - MichaelGG 12y ago
    Hard drugs isn't a category of drugs, but powerful opiates seem to be what's included anyways. I'm not aware of opiate users habitually taking off clothing. Other powerful drugs can make you feel cold, adding clothing. Some people really sweat on acid, which is probably a decent cause of taking off clothing.

ufmace 12y ago

I remember talking to somebody in the medical industry once. I don't remember exactly what his job was, but he told me that he had done some work with opiate addicts. Supposedly, their brains themselves can get so powerfully addicted to the drugs that it actually generates phantom pain in order to force the user to get more opiates to make it go away. Every test they can run shows that the addict is actually feeling real pain, but there is absolutely nothing physically wrong to cause it. The idea that the brain can work on that level, actually causing artificial sensations to trick our conscious mind, is both amazing and scary.

MichaelGG 12y ago
Forget physical pain. Opiates make the mental pain, the pain of existence go away. Stress, business problems, finances, it's all manageable with opiates. Most people don't know just how much better human existence can be with a bit of tweaking to our chemistry. We accept we're no longer in our ancestral environment, why can't we accept that our default chemistry is suboptimal?
- stefantalpalaru 12y ago
  Suboptimal in what way? We create, develop, improve because we are unsatisfied, not because we are happy.
  - MichaelGG 12y ago
    I don't think that's accurate. Certainly some people work jobs just to get cash to pay bills. But plenty of people create for the fun of it. Our brains operate suboptimal because we can not control their state. We get worried when it provides no benefit. We get sad and troubled when we shouldn't. We experience intense pain with no way to shut it off. We lose focus, even when we really want to concentrate. Everyone should have the capability and choice of modifying their brain chemistry on demand. Your premise that people should be forced to be unnecessarily unsatisfied because some of them might go on to do great things is cruel.
    - 12y ago