4 ms·

Mitochondrial diseases are also very rare -- so that particular domain may not be the lowest-hanging of fruits to go for initially.

• fasteo 13y ago
  Not so, numbers are being revised from 1:10.000 to as low as 1:1.000 Then, we have anti-aging. Big business here. Mitochondria is key. Then, we have diseases with secondary mitochondrial dysfunction. Again, big business (Alzheimer, Type 2 diabetes, statin-induced myopathy, etc)
  • dekhn 13y ago
    Could you point at a high quality reputable paper saying "as low as 1:1,000"? Did you mean 1 in 1000 people with disease have a mitochondrial cause, or 1 in 1000 people have a mitochondrially caused disease?
    • fasteo 13y ago
      I meant "1 in 1000 people with disease have a mitochondrial cause". There are many diferrent figures as "mitochondrial disease" is a broad term, but check these out: http://ije.oxfordjournals.org/content/41/1/177.long http://ije.oxfordjournals.org/content/41/1/177.long http://www.ncbi.nlm.nih.gov/pubmed/18674747?dopt=Abstract http://www.ncbi.nlm.nih.gov/pubmed/18674747?dopt=Abstract