"It is the building of fine bridges by Romans and Victorians in advance of material science and computer simulation." Not really - it is the equivalent of Roma

"It is the building of fine bridges by Romans and Victorians in advance of material science and computer simulation." Not really - it is the equivalent of Romans building bridges by sticking dirt together without figuring out the correct composition of building materials, why/how materials can cement, and so forth. "allotopic expression of mitochondrial genes is absolutely a way to fix protein expression issues." You are actively presenting bleeding edge research as a definite solution in spite of how primitive it is [1]. It is not immediately clear that allotopic expression is the answer, just because it worked in mice for one specific example it is not necessarily true that it translates to humans or other diseases. In fact, findings in mice often do not translate to humans [2]. "SENS is supported by a number of noted figures in the life sciences, including George Church, Anthony Atala, Judith Campisi, and so forth:" While I respect Campisi's work on senescence and aging there is obviously conflict here where one of the pioneers of the field is supportive of a theory that promotes her field. For this reason I think it is best that we do not defer to authority figures on this matter as you will find reputable authorities on both sides of this debate. "You are behind the times on calorie restriction research. It works very well on all measures of health in primates except for longevity." See [3] from de Cabo's group (who is one of the authors on the paper in the OP). If you're talking about increasing lifespan (one of the lofty goals of SENS) is longevity not the most important thing here? From this (respected) paper de Cabo points out many flaws in the studies on caloric restriction due to differing methodologies and genetic variation that resulted in adverse effects in some murine experiments. This is far from 'working well'. [1] http://www.genetics.org/content/165/2/707.short http://www.genetics.org/content/165/2/707.short [2] http://www.pnas.org/content/early/2013/02/07/1222878110.abstract http://www.pnas.org/content/early/2013/02/07/1222878110.abst... [3] http://www.nature.com/nature/journal/v489/n7415/full/nature11432.html http://www.nature.com/nature/journal/v489/n7415/full/nature1...