Yes, but I am also not surprised given this is pretty fundamental work, even if it hasn't quite hit the sort of revolutionary goals many of us hoped for. If Pe

Yes, but I am also not surprised given this is pretty fundamental work, even if it hasn't quite hit the sort of revolutionary goals many of us hoped for. If Peter Kollman had been alive, I suspect he would have shared this Nobel. This Nobel is hits very close to home. Much of my PhD work was done in CHARMM and I come from the Karplus lineage, and at one point in time I had pretty much read every paper Levitt and Warshel had ever written.