4 ms·

From https://en.wikipedia.org/wiki/Nicotine#Toxicology https://en.wikipedia.org/wiki/Nicotine#Toxicology Indirectly, nicotine increases cholinergic signalling

From https://en.wikipedia.org/wiki/Nicotine#Toxicology https://en.wikipedia.org/wiki/Nicotine#Toxicology Indirectly, nicotine increases cholinergic signalling (and adrenergic signalling in the case of colon cancer[77]), thereby impeding apoptosis (programmed cell death), promoting tumor growth, and activating growth factors and cellular mitogenic factors such as 5-LOX, and EGF. Nicotine also promotes cancer growth by stimulating angiogenesis and neovascularization.[78][79] In one study, nicotine administered to mice with tumors caused increases in tumor size (twofold increase), metastasis (nine-fold increase), and tumor recurrence (threefold increase).[80] It may not cause cancer directly, but it does sound pretty toxic and does help cancer growth. There might be a "safe" upper limit at which inhaling secondary smoke from e-cigarettes would have an insignificant impact, but we need more studios.

haldujai 13y ago
You'll be hard pressed to find anything stimulatory/anabolic that does not stimulate already existing cancers. The simplest example, protein consumption can also promote cancer growth (I can find a ref if pressed, I'm just lazy right now).
- rquantz 13y ago
  On the other hand, this study found that a high protein, low carb diet can reduce cancer growth in mice[1]. This is not to say that what you said is inaccurate. I just see your comment and the first thing I think is "uh oh, can I still eat paleo?" Given that anabolism can promote tumor growth, do weightlifters tend to have more intense bouts of cancer? [1] http://cancerres.aacrjournals.org/content/71/13/4484.full http://cancerres.aacrjournals.org/content/71/13/4484.full
  - haldujai 13y ago
    Remember that a high protein low carb diet is significantly different from a normal high carb high protein diet. As to the second point the best answer I can give you is maybe. Unfortunately different cancers have completely different mechanisms, while high protein may be bad for mammary cancers it might be good for bone cancers. So it's really situational.
    - rquantz 13y ago
      So what you're telling me is I can't have complete knowledge or control over my life? How am I going to live forever, then?? Edit: but seriously, thanks for the response. I think a lot of people are torn by trying to make basic decisions like this, and making sense of conflicting findings is pretty frustrating. Seems like a lot of carbs is bad, though, so I'm going to go with that.
      - haldujai 13y ago
        More importantly avoid fats :)
- jvrossb 13y ago
  Interested in a ref.
  - haldujai 13y ago
    [1] Effect of Casein, Lactalbumin, and Ovalbumin on 3-Methylcholanthrene-Induced Mammary Carcinoma in Rats. doi: 10.1093/jnci/33.2.243 [2] Effects of Varying the Proportion of Protein in the Diet. http://cancerres.aacrjournals.org/content/9/3/162.short http://cancerres.aacrjournals.org/content/9/3/162.short [3]The combined effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats. http://jn.nutrition.org/content/114/7/1213.long http://jn.nutrition.org/content/114/7/1213.long
    - jvrossb 13y ago
      Thanks!
AlexDanger 13y ago
If you consider e-cigs a harm reduction device, the carcinogenic potential of standalone nicotine dwarves that of traditional cigarettes. More research is needed but all the evidence so far points to e-cigs being safer than cigarettes for those who can not kick the habit. But the passive smoking impact is a very valid point and needs to be studied.
praxeologist 13y ago
You would probably take in more nicotine from eating a meal of eggplant than you would get from secondhand vapor. You wouldn't get enough from secondhand vapor to have psychoactive effects, let alone come anywhere near toxicity. Here is some reference to an indoor air quality showing vaping to not harm other people: www.ivaqs.com Here is reference to a study showing that nicotine did not promote lung cancer growth: http://www.aacr.org/home/public--media/aacr-in-the-news.aspx?d=2318 http://www.aacr.org/home/public--media/aacr-in-the-news.aspx... All sorts of things we take in can "promote cancer growth". Nicotine by itself is so far from a carcinogen that IARC doesn't even investigate it as one. There are roughly 50 components of tobacco and tobacco smoke called the "Hoffman analytes" which are the carcinogens. There are studies showing the relative cardiovascular and cancer risk, and the worst carcinogens are produced by burning plant material. These are not present in ecigs. Some studies which are dubious because of the choice of equipment and researchers not simulating the way ecigs are actually used have shown a handful of components way down the list of dangerous ingredients. Other studies have been done where these didn't even show up, but we are talking about things like formaldehyde and acetaldehyde near the level put out by smoking. If you compare the cancer risk of these to smoking, you are still looking at less than 5% of the cancer risk of smoking (probably under 1% really).

haldujai 13y ago

You'll be hard pressed to find anything stimulatory/anabolic that does not stimulate already existing cancers. The simplest example, protein consumption can also promote cancer growth (I can find a ref if pressed, I'm just lazy right now).

rquantz 13y ago
On the other hand, this study found that a high protein, low carb diet can reduce cancer growth in mice[1]. This is not to say that what you said is inaccurate. I just see your comment and the first thing I think is "uh oh, can I still eat paleo?" Given that anabolism can promote tumor growth, do weightlifters tend to have more intense bouts of cancer? [1] http://cancerres.aacrjournals.org/content/71/13/4484.full http://cancerres.aacrjournals.org/content/71/13/4484.full
- haldujai 13y ago
  Remember that a high protein low carb diet is significantly different from a normal high carb high protein diet. As to the second point the best answer I can give you is maybe. Unfortunately different cancers have completely different mechanisms, while high protein may be bad for mammary cancers it might be good for bone cancers. So it's really situational.
  - rquantz 13y ago
    So what you're telling me is I can't have complete knowledge or control over my life? How am I going to live forever, then?? Edit: but seriously, thanks for the response. I think a lot of people are torn by trying to make basic decisions like this, and making sense of conflicting findings is pretty frustrating. Seems like a lot of carbs is bad, though, so I'm going to go with that.
    - haldujai 13y ago
      More importantly avoid fats :)
jvrossb 13y ago
Interested in a ref.
- haldujai 13y ago
  [1] Effect of Casein, Lactalbumin, and Ovalbumin on 3-Methylcholanthrene-Induced Mammary Carcinoma in Rats. doi: 10.1093/jnci/33.2.243 [2] Effects of Varying the Proportion of Protein in the Diet. http://cancerres.aacrjournals.org/content/9/3/162.short http://cancerres.aacrjournals.org/content/9/3/162.short [3]The combined effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene-induced breast cancer in rats. http://jn.nutrition.org/content/114/7/1213.long http://jn.nutrition.org/content/114/7/1213.long
  - jvrossb 13y ago
    Thanks!

AlexDanger 13y ago

If you consider e-cigs a harm reduction device, the carcinogenic potential of standalone nicotine dwarves that of traditional cigarettes. More research is needed but all the evidence so far points to e-cigs being safer than cigarettes for those who can not kick the habit. But the passive smoking impact is a very valid point and needs to be studied.

praxeologist 13y ago

You would probably take in more nicotine from eating a meal of eggplant than you would get from secondhand vapor. You wouldn't get enough from secondhand vapor to have psychoactive effects, let alone come anywhere near toxicity. Here is some reference to an indoor air quality showing vaping to not harm other people: www.ivaqs.com Here is reference to a study showing that nicotine did not promote lung cancer growth: http://www.aacr.org/home/public--media/aacr-in-the-news.aspx?d=2318 http://www.aacr.org/home/public--media/aacr-in-the-news.aspx... All sorts of things we take in can "promote cancer growth". Nicotine by itself is so far from a carcinogen that IARC doesn't even investigate it as one. There are roughly 50 components of tobacco and tobacco smoke called the "Hoffman analytes" which are the carcinogens. There are studies showing the relative cardiovascular and cancer risk, and the worst carcinogens are produced by burning plant material. These are not present in ecigs. Some studies which are dubious because of the choice of equipment and researchers not simulating the way ecigs are actually used have shown a handful of components way down the list of dangerous ingredients. Other studies have been done where these didn't even show up, but we are talking about things like formaldehyde and acetaldehyde near the level put out by smoking. If you compare the cancer risk of these to smoking, you are still looking at less than 5% of the cancer risk of smoking (probably under 1% really).