5 ms·

Viagra as Diet Pill? One Day, Perhaps

52 points by youngerdryas 14y ago

fluidcruft 14y ago
Now, all they have to get it to do is cause tan skin and it's the trifecta.
- mmagin 14y ago
  http://en.wikipedia.org/wiki/Melanotan_II http://en.wikipedia.org/wiki/Melanotan_II
ginko 14y ago
Considering the large quantities of Viagra some people are already taking on a regular basis, shouldn't any weight loss effects in humans been noticed by now?
- Ralz 14y ago
  This explains all the ripped 60 year olds at my gym
  - bitwize 14y ago
    There's a new fad called Cenegenics which is basically a bodybuilding regimen, replete with steroids given under the rubric of "hormone replacement", for old men. They're running television ads featuring a shredded-looking 72-year-old doctor.
    - nwzpaperman 14y ago
      Anyone familiar with when hormones (steroids/HgH/precursors) started being scheduled as drugs in the US? Anyone bothered to ask why they are scheduled at all? We spend all of this time talking about elite competitive and, frequently, professional athletes using them, WHY??? Next thing you know, they're going to "schedule" websites... WHY?
      - CamperBob2 14y ago
        Not that I believe that any drugs should be prohibited by law, but to answer your question, go over to YouTube and look at the videos of people setting off the "Lunk Alarm" at Planet Fitness gyms.
        atdrummond 14y ago
        You know there's plenty of people in the startup sphere who powerlift or crossfit who are perfectly well-adjusted, normal human beings right? And perhaps those lunk alarm videos are to protest a series of ads in which powerlifters and bodybuilders are portrayed as narcissistic morons. Having lifted in one of the most serious gyms in London for both groups, I can say this is most certainly not an accurate depiction.
        CamperBob2 14y ago
        You know there's plenty of people in the startup sphere who powerlift or crossfit who are perfectly well-adjusted, normal human beings right? Yeah, and those aren't the people in the videos.
        atdrummond 14y ago
        The first "lunk alarm" video I ever viewed was of a West Point graduate who got tagged for his deadlift hitting the ground "too loudly". For every obnoxious video you may find, there's tens of threads in various bodybuilding and strength forums of people who were asked to leave for doing very basic and non-disruptive barbell lifts. Even if every single lunk alarm video was as you described, it wouldn't be sufficient to paint a picture of either the bodybuilding or the strength athletics community.
        CamperBob2 14y ago
        Even if every single lunk alarm video was as you described, it wouldn't be sufficient to paint a picture of either the bodybuilding or the strength athletics community. I missed the part where I tried to do that. Help me out? The videos I'm talking about are the ones where someone sets off the lunk alarm and is politely asked to take a chill pill, and responds by trying to tear the building off of its foundation.
    - bherms 14y ago
      What's wrong with working out and supplementing your decreasing hormone levels with artificial testosterone? I may be reading your comment in the wrong light, but I think the research on health benefits here are fascinating. Once you move away from the stupidity of people juicing to get as big as Ronnie Coleman and away from the use of them by people under the age of ~40, hormone replacement is actually pretty great. Women have been taking estrogen for years and it's not frowned upon.
      - robbiep 14y ago
        A few inaccuracies in your comment: Estrogen will induce breast and uterine cancers unless it is given with progesterone. Hardly zero side-effects. It is considered proper to only administer estrogen alone to women with severe symptoms of menopause. For the purpose of contraception, the COCP uses low levels which inhibit further hormone release by acting on the pituitary gland; it effectively simulates the state of pregnancy. Even this has risks especially for women with coagulation disorders. With regard to your comments about men receiving hormone supplementations: the problem here is that testosterone production doesn't actually decrease as you get older. Or at least, falling testosterone seems to be the result of, and not the cause of, age and lifestyle related changes and declines. This result was shared with my med school class by one of the principle investigators of the 2011 study in the links; I apologise for using science daily Links as I don't have access to research journals ATM http://www.webmd.com/healthy-aging/news/20110607/testosterone-decline-not-inevitable-with-age http://www.webmd.com/healthy-aging/news/20110607/testosteron... http://www.sciencedaily.com/releases/2011/06/110607121129.htm http://www.sciencedaily.com/releases/2011/06/110607121129.ht...
        bherms 14y ago
        Thanks for the information... It's a topic I've only briefly read about on a few occasions, so my knowledge clearly isn't too in depth.
- spindritf 14y ago
  Maybe users ascribed weight loss to increased... activity.
- mistercow 14y ago
  As far as I can tell, the maximum approved daily dose of Viagra is 100mg. If a 150 lb man takes that, you're looking at about 1.5 mg/kg/day, which is an eighth of what they gave the rats in this study. If I'm reading this other study (http://informahealthcare.com/doi/abs/10.1080/004982599238687 http://informahealthcare.com/doi/abs/10.1080/004982599238687) correctly, we could probably roughly triple the equivalent dose in rats to account for their more rapid clearance of sildenafil. So we're still looking at 2-3 times a large dose for humans, taken over an extended period of time. So we can reason right off the bat that this is an atypical use case. Glancing at experience reports on the internet, it appears pretty rare for people to exceed 100 mg doses, and even rarer for them to keep using it day after day for a week at a time. The one segment of the population we might expect to approach the level of usage tested in this study would be male porn stars. That's a group that is probably concerned more with building muscle than losing weight, so it seems unlikely that they'd be in a position to notice that particular effect.
  - Gatsky 14y ago
    There are studies of high dose chronic viagra use in patients with pulmonary arterial hupertension. The high dose groups in these studies received 240mg a day. I've had a brief look at the reported outcomes and there is no data on weightloss. This paediatric study of the same condition mentions that one patient withdrew due to weightloss: (http://m.circ.ahajournals.org/content/125/2/324.long http://m.circ.ahajournals.org/content/125/2/324.long) Of course, these patients are quite unwell, aren't trying to lose weight, and if sildenafil made their condition better might have had a better appetite and eaten more, so it's hard to draw too many conclusions.
  - throwaway54-762 14y ago
    Yeah, if you're a human male and consuming 200-300 mg of sildenafil daily, you are likely going to see other issues: both health (priapism), and social (uh, see: priapism).
vaadu 14y ago
Pfizer will use this as a way to extend their patents.
- mistercow 14y ago
  My understanding was that one of the criteria for a method-of-use extension is that the patent must not have previously been extended. Since Viagra has already been extended to 2020, I don't think it is eligible for another extension.
- danso 14y ago
  Some background. In the U.S., there are several characteristics that makes a drug something that the FDA approves: 1) The actual chemical makeup of the drug 2) The dosage of the drug 3) The method of administration for the drug 4. What the drug is intended to treat Therefore, Pfizer can get separate approvals for Viagra if they release 100 mg and 200mg doses. They get separate approvals if the drug is administered through pill or through injection. And they get separate approvals for Viagra if, in one case, Viagra is used to treat erectile dysfunction, and in the other, used to treat, say, ulcers. So, AFAIK, Pfizer can continue making money off of Viagra for this new intended use, if the FDA approves of it. However, I believe (talking from just layman's interpretation here), that this doesn't preclude someone getting a generic approved for erectile dysfunction, after Pfizer's exclusivity period has run out for that particular intended treatment. edit: This is a different issue than when they trivially modify the formulation of a drug in order to delay the possibility of a generic use. The regulations are a bit convoluted so take everything I wrote here with a grain of salt. But tl;dr: there's more to an "approved" product than just chemical formulation.
  - refurb 14y ago
    You are correct. If Pfizer conducted clinical trials and got Viagra approved for a new indication, they could extend their exclusivity two different ways: either through a use patent or through market exclusivity as provide by the FDA. However, if their patent is around the use of the drug, i.e. erectile dysfunction and that patent runs out, another company could make a generic. That company would not be able to promote the drug for the new indication, but doctors would know the two were the same and could prescribe the generic.
return0 14y ago
This Just In: "Average content size of spam emails expected to double"
driverdan 14y ago
This is pretty interesting research but how this plays out in humans could be very different. Mice have significantly more "brown" fat than humans. I could see that playing a role in the rate of conversion. Anyone with more knowledge of the topic care to comment?
gz5 14y ago
can't wait to see the Argaiv ads w/ the skinny actors smiling away and the low voice at the end warning us that our partners need to know about the side effects, perhaps talking just a bit slower than the normal disclaimers, and with a few more select adjectives about the side effect experience.
jondiggsit 14y ago
The obese male population in America is about to get a whole lot more gross
matznerd 14y ago
pssst, for those of you not into nootropics... you can take artichoke extract, which also inhibits phosphodiesterase 5 (PDE5) and elevates cGMP. there are also studies showing that inhibiting this pathway can also restore cognitive function... http://www.ncbi.nlm.nih.gov/pubmed/21627640# http://www.ncbi.nlm.nih.gov/pubmed/21627640#
ksherlock 14y ago
The NY Times better be careful. Peter Gleason, MD, committed suicide after the FDA/DOJ destroyed his career for discussing off-label usages of prescription drugs. http://www.justice.gov/usao/nye/pr/2006/2006apr05.html http://www.justice.gov/usao/nye/pr/2006/2006apr05.html http://online.wsj.com/article/SB10001424127887323981504578174973015235686.html http://online.wsj.com/article/SB1000142412788732398150457817...
- pstuart 14y ago
  Ugh. The WSJ article is behind a paywall, but from skimming the DOJ page it seems he was prescribing GHB, a drug that is considered to be safer than alcohol. Think of the children! /s
  - brianchu 14y ago
    There are aspects of GHB that are most certainly more dangerous than alcohol. It is much easier to overdose on GHB - several grams will do it. GHB is often used as a recreational drug which explains why it is a controlled substance. Combining it with alcohol can be particularly risky/fatal. I first heard of GHB, for example, in high school, because it's a common date rape drug.
    - pstuart 14y ago
      Alcohol is a date rape drug. All drugs are risky, including alcohol. We should teach our youth not that drugs are bad, but that they are powerful and can be dangerous. Use them if you will but do so wisely.
  - saraid216 14y ago
    > The WSJ article is behind a paywall http://webcache.googleusercontent.com/search?q=cache%3Ahttp%3A%2F%2Fonline.wsj.com%2Farticle%2FSB10001424127887323981504578174973015235686.html&oq=cache%3Ahttp%3A%2F%2Fonline.wsj.com%2Farticle%2FSB10001424127887323981504578174973015235686.html&aqs=chrome.0.57j58.1015&sourceid=chrome&ie=UTF-8 http://webcache.googleusercontent.com/search?q=cache%3Ahttp%...
atdrummond 14y ago
Ursolic acid (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039332 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjourna...) show promise of similar effects, although through a different mechanism of action. "As a result, ursolic acid increased skeletal muscle mass, fast and slow muscle fiber size, grip strength and exercise capacity. Interestingly, ursolic acid also increased brown fat, a tissue that shares developmental origins with skeletal muscle. Consistent with increased skeletal muscle and brown fat, ursolic acid increased energy expenditure, leading to reduced obesity, improved glucose tolerance and decreased hepatic steatosis." Patrick Arnold, the creator of "The Clear" and other designer steroids used by BALCO, currently produces an ursolic acid transdermal that many people claim to have been extremely effective for weight loss.
- nwzpaperman 14y ago
  PA is a brilliant guy that loves human performance and tinkering with the programming of the human body to make it better. HN is just a cold audience for this type of content. Keep those noses up y'all! edit - "...programming with the human body to optimize system performance."
  - atdrummond 14y ago
    Absolutely. Not only that but he regularly posts on forums and responds to e-mails, even those with the most basic of questions. He's working on a few cognitive products that might interest HN a bit more.
    - kanzure 14y ago
      What is his current email address? I just learned about Pat, but he's already my hero. His emails on USENET are hilarious. http://en.wikipedia.org/wiki/Patrick_Arnold http://en.wikipedia.org/wiki/Patrick_Arnold "Patrick Arnold is an American organic chemist and bodybuilder known for introducing androstenedione, 1-Androstenediol, and methylhexanamine into the dietary supplement market, and for creating the designer steroid tetrahydrogestrinone, also known as THG and "the clear".[1]" "THG, along with two other anabolic steroids that Patrick Arnold manufactured (norbolethone and desoxymethyltestosterone (DMT), were drugs at the heart of the BALCO professional sports doping scandal.[2] At the time of their creation, they were not on any banned substance list. BALCO distributed these worldwide to world class athletes from a wide variety of sports ranging from track and field to professional baseball and football." "Arnold who is also an amateur bodybuilder, initially gained notoriety as "the Father of Prohormones."[4]" "Arnold was sentenced to three months in prison at Federal Correctional Institution, Morgantown in West Virginia for his role in the BALCO incident.[1]" http://patrickarnoldblog.com/homemade-steroids-making-users-sick/ http://patrickarnoldblog.com/homemade-steroids-making-users-... "Patrick currently produces products for the nutritional supplement company E-pharm Nutrition, as well as for Prototype Nutrition. He continues to be perhaps the number one driving force in the advancement of performance enhancing nutritional supplementation." "Little did people realize though that part of the credit for McGuire’s amazing year was owed to chemist Patrick Arnold and his incredible new product androstenedione (a.k.a.Andro) which McGuire used to help him smash 70 homers that season." "A week after Arnold took his first dose of liquid mestanolone, his life began to change. At the gym, he was on fire. ... Arnold focused his efforts on a patent he came across while flipping through chemical abstracts. It came from an East German pharmaceutical company called Jenapharm, which produced most of the steroidal compounds used in the former communist nation’s athletic doping program." "Just as Arnold suspected, norbolethone was so obscure that professional doping programs had no reference sample and thus could not detect it." https://groups.google.com/forum/?fromgroups=#!topic/diybio/_nfom6eIrJA https://groups.google.com/forum/?fromgroups=#!topic/diybio/_...
cjensen 14y ago
So a guy "fed the drug to mice for seven days" and discovered "white fat cells ... were being converted ... at a higher rate than usual." I give this study a zero for effort. Would it have killed them to study this for longer? Where's my control group that is heavier at the end of the study?

52 points by youngerdryas 14y ago

fluidcruft 14y ago

Now, all they have to get it to do is cause tan skin and it's the trifecta.

mmagin 14y ago
http://en.wikipedia.org/wiki/Melanotan_II http://en.wikipedia.org/wiki/Melanotan_II

ginko 14y ago

Considering the large quantities of Viagra some people are already taking on a regular basis, shouldn't any weight loss effects in humans been noticed by now?

Ralz 14y ago
This explains all the ripped 60 year olds at my gym
- bitwize 14y ago
  There's a new fad called Cenegenics which is basically a bodybuilding regimen, replete with steroids given under the rubric of "hormone replacement", for old men. They're running television ads featuring a shredded-looking 72-year-old doctor.
  - nwzpaperman 14y ago
    Anyone familiar with when hormones (steroids/HgH/precursors) started being scheduled as drugs in the US? Anyone bothered to ask why they are scheduled at all? We spend all of this time talking about elite competitive and, frequently, professional athletes using them, WHY??? Next thing you know, they're going to "schedule" websites... WHY?
    - CamperBob2 14y ago
      Not that I believe that any drugs should be prohibited by law, but to answer your question, go over to YouTube and look at the videos of people setting off the "Lunk Alarm" at Planet Fitness gyms.
      - atdrummond 14y ago
        You know there's plenty of people in the startup sphere who powerlift or crossfit who are perfectly well-adjusted, normal human beings right? And perhaps those lunk alarm videos are to protest a series of ads in which powerlifters and bodybuilders are portrayed as narcissistic morons. Having lifted in one of the most serious gyms in London for both groups, I can say this is most certainly not an accurate depiction.
        CamperBob2 14y ago
        You know there's plenty of people in the startup sphere who powerlift or crossfit who are perfectly well-adjusted, normal human beings right? Yeah, and those aren't the people in the videos.
        atdrummond 14y ago
        The first "lunk alarm" video I ever viewed was of a West Point graduate who got tagged for his deadlift hitting the ground "too loudly". For every obnoxious video you may find, there's tens of threads in various bodybuilding and strength forums of people who were asked to leave for doing very basic and non-disruptive barbell lifts. Even if every single lunk alarm video was as you described, it wouldn't be sufficient to paint a picture of either the bodybuilding or the strength athletics community.
        CamperBob2 14y ago
        Even if every single lunk alarm video was as you described, it wouldn't be sufficient to paint a picture of either the bodybuilding or the strength athletics community. I missed the part where I tried to do that. Help me out? The videos I'm talking about are the ones where someone sets off the lunk alarm and is politely asked to take a chill pill, and responds by trying to tear the building off of its foundation.
  - bherms 14y ago
    What's wrong with working out and supplementing your decreasing hormone levels with artificial testosterone? I may be reading your comment in the wrong light, but I think the research on health benefits here are fascinating. Once you move away from the stupidity of people juicing to get as big as Ronnie Coleman and away from the use of them by people under the age of ~40, hormone replacement is actually pretty great. Women have been taking estrogen for years and it's not frowned upon.
    - robbiep 14y ago
      A few inaccuracies in your comment: Estrogen will induce breast and uterine cancers unless it is given with progesterone. Hardly zero side-effects. It is considered proper to only administer estrogen alone to women with severe symptoms of menopause. For the purpose of contraception, the COCP uses low levels which inhibit further hormone release by acting on the pituitary gland; it effectively simulates the state of pregnancy. Even this has risks especially for women with coagulation disorders. With regard to your comments about men receiving hormone supplementations: the problem here is that testosterone production doesn't actually decrease as you get older. Or at least, falling testosterone seems to be the result of, and not the cause of, age and lifestyle related changes and declines. This result was shared with my med school class by one of the principle investigators of the 2011 study in the links; I apologise for using science daily Links as I don't have access to research journals ATM http://www.webmd.com/healthy-aging/news/20110607/testosterone-decline-not-inevitable-with-age http://www.webmd.com/healthy-aging/news/20110607/testosteron... http://www.sciencedaily.com/releases/2011/06/110607121129.htm http://www.sciencedaily.com/releases/2011/06/110607121129.ht...
      - bherms 14y ago
        Thanks for the information... It's a topic I've only briefly read about on a few occasions, so my knowledge clearly isn't too in depth.
spindritf 14y ago
Maybe users ascribed weight loss to increased... activity.
mistercow 14y ago
As far as I can tell, the maximum approved daily dose of Viagra is 100mg. If a 150 lb man takes that, you're looking at about 1.5 mg/kg/day, which is an eighth of what they gave the rats in this study. If I'm reading this other study (http://informahealthcare.com/doi/abs/10.1080/004982599238687 http://informahealthcare.com/doi/abs/10.1080/004982599238687) correctly, we could probably roughly triple the equivalent dose in rats to account for their more rapid clearance of sildenafil. So we're still looking at 2-3 times a large dose for humans, taken over an extended period of time. So we can reason right off the bat that this is an atypical use case. Glancing at experience reports on the internet, it appears pretty rare for people to exceed 100 mg doses, and even rarer for them to keep using it day after day for a week at a time. The one segment of the population we might expect to approach the level of usage tested in this study would be male porn stars. That's a group that is probably concerned more with building muscle than losing weight, so it seems unlikely that they'd be in a position to notice that particular effect.
- Gatsky 14y ago
  There are studies of high dose chronic viagra use in patients with pulmonary arterial hupertension. The high dose groups in these studies received 240mg a day. I've had a brief look at the reported outcomes and there is no data on weightloss. This paediatric study of the same condition mentions that one patient withdrew due to weightloss: (http://m.circ.ahajournals.org/content/125/2/324.long http://m.circ.ahajournals.org/content/125/2/324.long) Of course, these patients are quite unwell, aren't trying to lose weight, and if sildenafil made their condition better might have had a better appetite and eaten more, so it's hard to draw too many conclusions.
- throwaway54-762 14y ago
  Yeah, if you're a human male and consuming 200-300 mg of sildenafil daily, you are likely going to see other issues: both health (priapism), and social (uh, see: priapism).

vaadu 14y ago

Pfizer will use this as a way to extend their patents.

mistercow 14y ago
My understanding was that one of the criteria for a method-of-use extension is that the patent must not have previously been extended. Since Viagra has already been extended to 2020, I don't think it is eligible for another extension.
danso 14y ago
Some background. In the U.S., there are several characteristics that makes a drug something that the FDA approves: 1) The actual chemical makeup of the drug 2) The dosage of the drug 3) The method of administration for the drug 4. What the drug is intended to treat Therefore, Pfizer can get separate approvals for Viagra if they release 100 mg and 200mg doses. They get separate approvals if the drug is administered through pill or through injection. And they get separate approvals for Viagra if, in one case, Viagra is used to treat erectile dysfunction, and in the other, used to treat, say, ulcers. So, AFAIK, Pfizer can continue making money off of Viagra for this new intended use, if the FDA approves of it. However, I believe (talking from just layman's interpretation here), that this doesn't preclude someone getting a generic approved for erectile dysfunction, after Pfizer's exclusivity period has run out for that particular intended treatment. edit: This is a different issue than when they trivially modify the formulation of a drug in order to delay the possibility of a generic use. The regulations are a bit convoluted so take everything I wrote here with a grain of salt. But tl;dr: there's more to an "approved" product than just chemical formulation.
- refurb 14y ago
  You are correct. If Pfizer conducted clinical trials and got Viagra approved for a new indication, they could extend their exclusivity two different ways: either through a use patent or through market exclusivity as provide by the FDA. However, if their patent is around the use of the drug, i.e. erectile dysfunction and that patent runs out, another company could make a generic. That company would not be able to promote the drug for the new indication, but doctors would know the two were the same and could prescribe the generic.

return0 14y ago

This Just In: "Average content size of spam emails expected to double"

driverdan 14y ago

This is pretty interesting research but how this plays out in humans could be very different. Mice have significantly more "brown" fat than humans. I could see that playing a role in the rate of conversion. Anyone with more knowledge of the topic care to comment?

gz5 14y ago

can't wait to see the Argaiv ads w/ the skinny actors smiling away and the low voice at the end warning us that our partners need to know about the side effects, perhaps talking just a bit slower than the normal disclaimers, and with a few more select adjectives about the side effect experience.

jondiggsit 14y ago

The obese male population in America is about to get a whole lot more gross

matznerd 14y ago

pssst, for those of you not into nootropics... you can take artichoke extract, which also inhibits phosphodiesterase 5 (PDE5) and elevates cGMP. there are also studies showing that inhibiting this pathway can also restore cognitive function... http://www.ncbi.nlm.nih.gov/pubmed/21627640# http://www.ncbi.nlm.nih.gov/pubmed/21627640#

ksherlock 14y ago

The NY Times better be careful. Peter Gleason, MD, committed suicide after the FDA/DOJ destroyed his career for discussing off-label usages of prescription drugs. http://www.justice.gov/usao/nye/pr/2006/2006apr05.html http://www.justice.gov/usao/nye/pr/2006/2006apr05.html http://online.wsj.com/article/SB10001424127887323981504578174973015235686.html http://online.wsj.com/article/SB1000142412788732398150457817...

pstuart 14y ago
Ugh. The WSJ article is behind a paywall, but from skimming the DOJ page it seems he was prescribing GHB, a drug that is considered to be safer than alcohol. Think of the children! /s
- brianchu 14y ago
  There are aspects of GHB that are most certainly more dangerous than alcohol. It is much easier to overdose on GHB - several grams will do it. GHB is often used as a recreational drug which explains why it is a controlled substance. Combining it with alcohol can be particularly risky/fatal. I first heard of GHB, for example, in high school, because it's a common date rape drug.
  - pstuart 14y ago
    Alcohol is a date rape drug. All drugs are risky, including alcohol. We should teach our youth not that drugs are bad, but that they are powerful and can be dangerous. Use them if you will but do so wisely.
- saraid216 14y ago
  > The WSJ article is behind a paywall http://webcache.googleusercontent.com/search?q=cache%3Ahttp%3A%2F%2Fonline.wsj.com%2Farticle%2FSB10001424127887323981504578174973015235686.html&oq=cache%3Ahttp%3A%2F%2Fonline.wsj.com%2Farticle%2FSB10001424127887323981504578174973015235686.html&aqs=chrome.0.57j58.1015&sourceid=chrome&ie=UTF-8 http://webcache.googleusercontent.com/search?q=cache%3Ahttp%...

atdrummond 14y ago

Ursolic acid (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039332 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjourna...) show promise of similar effects, although through a different mechanism of action. "As a result, ursolic acid increased skeletal muscle mass, fast and slow muscle fiber size, grip strength and exercise capacity. Interestingly, ursolic acid also increased brown fat, a tissue that shares developmental origins with skeletal muscle. Consistent with increased skeletal muscle and brown fat, ursolic acid increased energy expenditure, leading to reduced obesity, improved glucose tolerance and decreased hepatic steatosis." Patrick Arnold, the creator of "The Clear" and other designer steroids used by BALCO, currently produces an ursolic acid transdermal that many people claim to have been extremely effective for weight loss.

nwzpaperman 14y ago
PA is a brilliant guy that loves human performance and tinkering with the programming of the human body to make it better. HN is just a cold audience for this type of content. Keep those noses up y'all! edit - "...programming with the human body to optimize system performance."
- atdrummond 14y ago
  Absolutely. Not only that but he regularly posts on forums and responds to e-mails, even those with the most basic of questions. He's working on a few cognitive products that might interest HN a bit more.
  - kanzure 14y ago
    What is his current email address? I just learned about Pat, but he's already my hero. His emails on USENET are hilarious. http://en.wikipedia.org/wiki/Patrick_Arnold http://en.wikipedia.org/wiki/Patrick_Arnold "Patrick Arnold is an American organic chemist and bodybuilder known for introducing androstenedione, 1-Androstenediol, and methylhexanamine into the dietary supplement market, and for creating the designer steroid tetrahydrogestrinone, also known as THG and "the clear".[1]" "THG, along with two other anabolic steroids that Patrick Arnold manufactured (norbolethone and desoxymethyltestosterone (DMT), were drugs at the heart of the BALCO professional sports doping scandal.[2] At the time of their creation, they were not on any banned substance list. BALCO distributed these worldwide to world class athletes from a wide variety of sports ranging from track and field to professional baseball and football." "Arnold who is also an amateur bodybuilder, initially gained notoriety as "the Father of Prohormones."[4]" "Arnold was sentenced to three months in prison at Federal Correctional Institution, Morgantown in West Virginia for his role in the BALCO incident.[1]" http://patrickarnoldblog.com/homemade-steroids-making-users-sick/ http://patrickarnoldblog.com/homemade-steroids-making-users-... "Patrick currently produces products for the nutritional supplement company E-pharm Nutrition, as well as for Prototype Nutrition. He continues to be perhaps the number one driving force in the advancement of performance enhancing nutritional supplementation." "Little did people realize though that part of the credit for McGuire’s amazing year was owed to chemist Patrick Arnold and his incredible new product androstenedione (a.k.a.Andro) which McGuire used to help him smash 70 homers that season." "A week after Arnold took his first dose of liquid mestanolone, his life began to change. At the gym, he was on fire. ... Arnold focused his efforts on a patent he came across while flipping through chemical abstracts. It came from an East German pharmaceutical company called Jenapharm, which produced most of the steroidal compounds used in the former communist nation’s athletic doping program." "Just as Arnold suspected, norbolethone was so obscure that professional doping programs had no reference sample and thus could not detect it." https://groups.google.com/forum/?fromgroups=#!topic/diybio/_nfom6eIrJA https://groups.google.com/forum/?fromgroups=#!topic/diybio/_...

cjensen 14y ago

So a guy "fed the drug to mice for seven days" and discovered "white fat cells ... were being converted ... at a higher rate than usual." I give this study a zero for effort. Would it have killed them to study this for longer? Where's my control group that is heavier at the end of the study?