Your benchmarks are likely very biased. The vast majority of the work done by your bioinformatics programs should be done in C code, with thin wrappers so that

Your benchmarks are likely very biased. The vast majority of the work done by your bioinformatics programs should be done in C code, with thin wrappers so that the code can be accessed through Perl and Python. If anything, your benchmarks only comparing specific implementations, such as BioPerl vs BioPython.