2 ms·

> The problem is that the gap between a medicinal dose and a toxic dose is very small What's this claim based on? I don't think it's the rat study linked near

> The problem is that the gap between a medicinal dose and a toxic dose is very small What's this claim based on? I don't think it's the rat study linked nearby. I looked through it and they didn't really compare doses. If it's a linear effect on dropping blood pressure, that seems like an overblown way to talk about it. If it's something else, I'd love to hear more.

SoftTalker 2mo ago
I also wondered why, if it has this effect, it has not been purified to a standard concentration (or synthesized) and used to treat high blood pressure. Possibly because accidental overdose can be fatal?
- atomicthumbs 2mo ago
  because we already have actual medication that does that in a controllable and well-characterized way
- pnw 2mo ago
  Grayanotoxin is a neurotoxin with a lot of unpleasant side effects. It would make a terrible drug for high blood pressure.
- cma 2mo ago
  There could be a case for doing it for people that will refuse anything but natural if it doesn't have other problems, assuming not synthesized, but there's a problem of funding the safety studies and standardization process if a patent is unlikely to result.
what_hn 2mo ago
[dead]
maxerickson 2mo ago
If you maintain the pairing with the statement about the concentration in the honey varying, it's somewhat harder to argue that it is overblown. The concentration varies considerably due to bees harvesting pollen from different flowers and from some batches of honey being mixed and some not.
- Dylan16807 2mo ago
  > If you maintain the pairing with the statement about the concentration in the honey varying, it's somewhat harder to argue that it is overblown. Those are two separate worries connected by an "and". I'm not arguing worry #2 is overblown. And it sounds like the problem of variance is that it isn't small. If one batch can be 5x as strong as another (made up number), then even a pretty good medicinal response curve leaves you vulnerable to that much variance.
  - ld50safe 2mo ago
    [dead]

SoftTalker 2mo ago

I also wondered why, if it has this effect, it has not been purified to a standard concentration (or synthesized) and used to treat high blood pressure. Possibly because accidental overdose can be fatal?

atomicthumbs 2mo ago
because we already have actual medication that does that in a controllable and well-characterized way
pnw 2mo ago
Grayanotoxin is a neurotoxin with a lot of unpleasant side effects. It would make a terrible drug for high blood pressure.
cma 2mo ago
There could be a case for doing it for people that will refuse anything but natural if it doesn't have other problems, assuming not synthesized, but there's a problem of funding the safety studies and standardization process if a patent is unlikely to result.

what_hn 2mo ago

[dead]

maxerickson 2mo ago

If you maintain the pairing with the statement about the concentration in the honey varying, it's somewhat harder to argue that it is overblown. The concentration varies considerably due to bees harvesting pollen from different flowers and from some batches of honey being mixed and some not.

Dylan16807 2mo ago
> If you maintain the pairing with the statement about the concentration in the honey varying, it's somewhat harder to argue that it is overblown. Those are two separate worries connected by an "and". I'm not arguing worry #2 is overblown. And it sounds like the problem of variance is that it isn't small. If one batch can be 5x as strong as another (made up number), then even a pretty good medicinal response curve leaves you vulnerable to that much variance.
- ld50safe 2mo ago
  [dead]