4 ms·
The brain may be about to have its Ozempic moment
- SoupBread 2mo agoIt sounds like is a genuine treatment for those who suffer from narcolepsy, and everything else is merely speculative and has seem pretty bad side-effects.
- bitexploder 2mo agoThere is evidence that some forms of ADHD are effectively just the brain falling asleep rapidly and then waking up. This form cam be attenuated with norepinephrine reuptake inhibitor alone. Presents with ADHD like symptoms. But it’s a new thing most likely. Called “Cognitive Disengagement Syndrome”.
- ykonstant 2mo agoFor the record, since I am on a mix of concerta and effexor, effexor alone does nothing to alleviate my symptoms (at the 150mg dosage). Although for me the adhd medication is no problem. It is actually effexor that torments me, because I have extreme withdrawal symptoms if I go even one day without it.
- infinite_spin 2mo agoit's possible your doctor is treating you for depression as well as ADHD
- nextaccountic 2mo agoOr maybe venlafaxine is to counteract any anxiety that the upper may cause. Well that's the theory my doctor had anyway. (I took venlafaxine with ADHD meds because of this)
- poulpy123 2mo agoEffector is for dépression not ADHD. Do you get brain zap when you miss a dose ? Other medications don't have this problem, at least for many of not most people
- ykonstant 2mo agoRight, the reason I am mentioning effexor is because venlafaxine is one of the basic SNRIs, relevant to the parent comment.
- __alias 2mo agoWow. First i've heard of this but the description sound so relatable. Very interesting, and makes total sense to differentiate from ADHD
- Anon84 2mo agohttps://archive.md/LWDUq https://archive.md/LWDUq
- copperx 2mo agoA better modafinil? Sign me up.
- fennec-posix 2mo agoIf this means I don't have to take Methylphenidate to function 100% all the time and as a result feel tremendously anxious 100% all the time. SIGN ME UP.
- SV_BubbleTime 2mo agoYou sure about that math?
- fennec-posix 2mo agoI'm honestly not sure about anything man
- SV_BubbleTime 2mo agoGet off pharma. Do whatever it takes.
- didgeoridoo 2mo agoAdding guanfacine (Intuniv) to my methylphenidate took the weird anxious-angry edge off. Would be nice to not have to take one med to fix the side effects of the other, though.
- hirvi74 2mo agoAny other benefits?
- didgeoridoo 2mo agoIt’s also a blood pressure med, so I went from borderline prehypertensive to perfect 105/70. You can’t go on and off it at will though, since you’ll get rebound high BP if you don’t taper.
- fennec-posix 2mo agoInteresting, will check it out. Cheers!
- ValdikSS 2mo agoHooray fatal insomnia
- EA-3167 2mo agoThe second I read the print in Nature a bit ago I knew some version would show up here. I swear I’ve met deployed Marines less obsessed with staying awake through chemistry than some people here.
- oblio 2mo ago1. Virtue signaling. 2. Unhealthy desire to get rich (or work on interesting projects, which would be the better option).
- AnneTrotter 2mo agoDo they sell caffeinated crayons yet? If not I have a startup idea-
- steele 2mo ago[flagged]
- almost_usual 2mo agoSleep less and sit more. What a species we’ve become.
- deleted 2mo ago[deleted]
- acosmism 2mo agowow. now i'm really excited for the future
- WalterGR 2mo ago185 comments 2 weeks ago: https://news.ycombinator.com/item?id=49263658 https://news.ycombinator.com/item?id=49263658
- Kinrany 2mo agoInteresting comment: https://news.ycombinator.com/item?id=49264602 https://news.ycombinator.com/item?id=49264602 > IMO the much more likely explanation is that the brain uses contrastive learning somewhere. [...] Instead of using calculus and outer products to calculate derivatives, you feed real data and false data forward through the network and each neuron tracks and trains on the difference.
- Kinrany 2mo agoI'm curious if there is an explanation for it not being more common to sleep like dolphins do, small parts of the brain at a time.
- sig-11 2mo agoYou may be thinking of sharks.
- Kinrany 2mo agoSeparately, do I understand the idea correctly: - when learning on the real examples, just propagate forward - when learning on the fake examples, first generate them by propagating white noise backward
- inigyou 2mo agoThat's a technique that was tried in machine learning and worked (although obviously not optimally or we'd all be using it by now) and then we hypothesised that animal brains use it because it would explain sleep.
- kbrannigan 2mo agoTo get a job at our company take three pills of brainOzempic every day to maximize productivity. We have our NeuroLinkBrain Implant plugin to AI agent , so that you can vibe code 24/7 . To maximize shareholder value.
- vhcr 2mo agoIsn't this already happening with ADHD drugs?
- rc5150 2mo agoon the recreational level, maybe, but from a therapeutic perspective for people who actually benefit from its prescribed use its absolutely game-changing to live a life without (or with mitigated) executive dysfunction.
- yuye 2mo agoA lot of people with ADHD that have success with medication can tell you that it's not just about work. It also helps with non-work stuff that's just not fun to do, such as chores or filing your taxes. It even helps you stick with hobbies you actually enjoy but your brain gets bored of.
- chocrates 2mo agoDon't tell me psychiatrist but I take my addon Ritalin at night so I can play games or read a book. I just can't do it without it
- blackjack_ 2mo agoTo some extent ADHD drugs are abused but to us neurodivergent people those stimulants (or in other cases just alpha 2 agonists) just help us do normal things that normal people can do without drugs, like laundry. Or reading a book, or be able to focus on literally anything that isn’t giving us a high level dopamine response. The meds (both stimulant and non stimulant) help people with ADHD choose where to hyperfocus, but hyperfocus is an internal trait of the ADHD neurotype, so it isn’t just attributable to the drugs or something. I.e. normal people use stimulants to go fast, while ND people with ADHD use them to go slow or have their brain actually be able to slow down.
- livinglist 2mo ago24/7 stock market, least sleep needed, most AI piled, I’m very excited!
- inigyou 2mo agoCryptocurrency markets are open 24/7 btw. Everyone involved in a stock market agrees it's quite useful to have a separation between days, although you could have a 23.5/7 stock market with only half hour day-ends. That's when things like index rebalancing, addition, removal, stock splits occur. You say whoever holds stock X at end of a certain day holds stock Y+Z at the start of the next day (due to a company splitting up) and there's no need to argue about which millisecond a trade occurred. (It's your own damn fault if you were trying to buy the stock in the milliseconds before closing, but some exchanges run a special closing auction with a different algorithm to prevent races). It's also the time you can deploy software, which you can't do during the day. Maybe half an hour is too short for all this stuff. Or maybe it should be a 12 hour window once a week instead.
- WalterGR 2mo agoAnd isn’t forex 24/5?
- notpushkin 2mo agoI think you can have a separation between days while still allowing 24/7 trading. Just schedule automatic operations like stock splits at midnight, and with a proper staging environment you can deploy software in the middle of the day, too (just give a heads-up first). And of course, overnight trading is available on some stock exchanges now. (I’m not sure whether this is a new thing or has existed for a while, but I’ve only noticed it on TradingView for some papers about a year ago I think.)
- fishfasell 2mo agoDespite the stigma surrounding semaglutide, its impact across various health conditions has been remarkable. Bringing that same level of innovation to cognitive disorders could be truly transformative for society
- JKCalhoun 2mo agoI've not detected a stigma around semaglutide. Is it from these Valley Bros I read about experimenting with designer semaglutide on themselves? Or is there another stigma?
- AnneTrotter 2mo agoThere's a crust of "but that's cheating" folks who have opinions on "taking drugs to lose weight". They're ignorant, of course, but that never stopped anyone from being loud.
- madhacker 2mo ago"Others are exploring their use for treating sleep apnoea, which is a far more common disorder." CPAP biomedical equipment manufacturer watch out!
- wewewedxfgdf 2mo agoI like sleep - it's not a problem to be solved.
- WesolyKubeczek 2mo agoSince we’re talking narcolepsy here, your passengers might disagree
- kajaktum 2mo agoJust imagine yourself never needing (or even able to) sleep. It is actually a nightmare. Your bad day is now permanent.
- WesolyKubeczek 2mo agoThere are levels to that: 1) don’t need to sleep, be able to sleep: the coolest thing in the universe. 2) don’t need to sleep, be unable to sleep: you would likely cope. Also, be an irreplaceable shift worker. 3) need to sleep, be able to sleep: this is where most of us are now, nothing to write home about. 4) need to sleep, be unable to sleep: the rest of your life is short and full of exponentially growing suffering. By „don’t need to sleep” I mean that the body refreshes itself by different means and you still reap the benefits. I can’t really imagine how it would feel, much like I can’t imagine being immortal. Most fiction describing those phenomena as „nightmare” usually is about a character who gains the ability but none of the protective mechanisms.
- fedpost 2mo agoWell, they're filming the next season of black mirror right now, it's probably not too late to throw this one in there.
- protocolture 2mo agoIts going to be 12 episodes of "What if Datacenter took my water" and similar isnt it?
- red75prime 2mo agoYeah, they need a bit of fiction there after all.
- deleted 2mo ago[deleted]
- derefr 2mo agoMy partner has had idiopathic hypersomnia (sleeps 12 hours most days, as much as 18 hours some days) for a few years now, and so far nothing we’ve tried has worked without awful side effects (e.g. constant heart palpitations and panic attacks.) I had been looking into orexin agonists (along with other things like H3 autoreceptor antagonists) back when they were just a concept. It’s good to see them finally reaching commercialization. Although they’re not approved by our own (Canadian) regulatory body quite yet. Now that they’re approved in the US, though, I’m looking very much forward to seeing how these drugs perform in off-label-ish treatment of the various other sleep disorders that I’m sure clinicians will now begin throwing them at.
- chasebank 2mo agoHave they tried GHB? I know it's used in narcolepsy patients with great success. If you "microdose" it, it's also one of the best drugs on the planet. Slippery slope, though.
- pprotas 2mo agoPlease don’t ever recommend this extremely addictive drug to strangers on the internet again
- sph 2mo agoCalm down, we’re all adults here, or pretending to be.
- pprotas 2mo agoI am calm. GHB has wreaked havoc in The Netherlands, it is something tweakers consume. Recommending microdosing GHB in my eyes is like recommending microdosing heroin. https://www.jellinek.nl/en/alcohol-drugs-behavior/ghb/ https://www.jellinek.nl/en/alcohol-drugs-behavior/ghb/ > GHB is difficult to dose. The difference between a dose with pleasant effects and the dose at which someone becomes overwhelmed by sleep and becomes unconscious is very small. People quickly take too much GHB. The combination with alcohol enhances the effects of GHB. This means that people can become unconscious even with a small dose of GHB.
- blinkbat 2mo agoAw hell no
- stego-tech 2mo agoI’m not about to stifle research into genuinely useful therapies just because some aspects of society will abuse the absolute shit out of them, and these therapies seem profoundly useful to those who suffer from the mentioned ailments. Here’s the thing: what a lot of these drugs are doing are basically acting as equivalents to the store-bought neurotransmitters you’d find in things like SSRIs or -phetamines/stimulants. To people lacking in these substances, they’re game changers. The problem right now is a mismatch between regulation, availability, and testing regimes. Regulations are meant to prevent dystopian shit like employers mandating (or encouraging) a drug regimen for employment through threat of punitive fines or prosecution, while the private insurance markets promote unaffordability domestically (as North America is where over half of pharma revenues come from) and testing regimes fail to identify who is best suited for a given drug. All three of these prongs will shake out in time, but cause new problems as a result. Where we’re at right now is less of a click-baity headline from The Economist, and more at the start of a new frontier in medicine that capitalizes on decades of research. We’ve maximized the benefits of “low-hanging” chemical-based drugs, and have moved into more complex, nuanced, or targeted drugs developed through modern compute rather than traditional drug trials alone. Things will change very quickly, and then stagnate again when we’ve picked clean the easy fruits from these new branches.
- brador 2mo agoWith so much malformed/fake diagnosis out there for mental health the data, research and conclusions will be a mess obscuring and obfuscating truth. The only way through will be anecdata. Science of one. I await basic safety reports.