3 ms·

Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest. Tadalafil [1] followed the

Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest. Tadalafil [1] followed the path of Sildenafil about the phosphodiesterase type 5 (PDE5) enzyme inhibitor. Help to live longer was the main objective since the beginning. [0] https://en.wikipedia.org/wiki/Sildenafil#History https://en.wikipedia.org/wiki/Sildenafil#History [1] https://en.wikipedia.org/wiki/Tadalafil#History https://en.wikipedia.org/wiki/Tadalafil#History

joezydeco 2mo ago
I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation. And all we got was another boner pill.
- fny 2mo ago
  Lifespans and inflammation are ironically harder problems.
  - mykowebhn 2mo ago
    Yes, but we don't want medical science to go soft by focusing on the easy problems.
    - miguelxpn 2mo ago
      But the whole point of those pills is that it didn't go soft anymore!
      - butvacuum 2mo ago
        thus this inuendo thread ended prematurely.
- fragmede 2mo ago
  During your extended lifetime, wouldn't you like to be able to have a boner, though?
  - NordStreamYacht 2mo ago
    Picasso managed it all without these meds.
    - fragmede 2mo ago
      If you're saying it's easy, just be as good as Picasso, imma be real with you and say I'm not as good as Picasso.
      - graceful6800 2mo ago
        ....in bed
- giantg2 2mo ago
  Quanity and/or quality of sex shows correlation with longer lifespan. Maybe this is a roundabout way to get there...
  - croemer 2mo ago
    Healthy people have more sex I guess?
  - joezydeco 2mo ago
    I do admire the fact that someone with a sense of humor at ICOS named the molecule TADA-lafil.
- VyseofArcadia 2mo ago
  Well they extended something at least.
- m463 2mo ago
  some lifespans are shorter when insemination never occurs.

3 ms·

Sildenafil [0] was synthesized to treat high blood pressure. Erectile disfunction was a side effect that raised much more interest. Tadalafil [1] followed the

by woliveirajr 2mo ago

joezydeco 2mo ago
I invested heavily in ICOS when they launched, they had Bill Gates money and were looking for ways to extend lifespans and solve inflammation. And all we got was another boner pill.
- fny 2mo ago
  Lifespans and inflammation are ironically harder problems.
  - mykowebhn 2mo ago
    Yes, but we don't want medical science to go soft by focusing on the easy problems.
    - miguelxpn 2mo ago
      But the whole point of those pills is that it didn't go soft anymore!
      - butvacuum 2mo ago
        thus this inuendo thread ended prematurely.
- fragmede 2mo ago
  During your extended lifetime, wouldn't you like to be able to have a boner, though?
  - NordStreamYacht 2mo ago
    Picasso managed it all without these meds.
    - fragmede 2mo ago
      If you're saying it's easy, just be as good as Picasso, imma be real with you and say I'm not as good as Picasso.
      - graceful6800 2mo ago
        ....in bed
- giantg2 2mo ago
  Quanity and/or quality of sex shows correlation with longer lifespan. Maybe this is a roundabout way to get there...
  - croemer 2mo ago
    Healthy people have more sex I guess?
  - joezydeco 2mo ago
    I do admire the fact that someone with a sense of humor at ICOS named the molecule TADA-lafil.
- VyseofArcadia 2mo ago
  Well they extended something at least.
- m463 2mo ago
  some lifespans are shorter when insemination never occurs.