4 ms·

From the article: “He’d waffle between jittery agitation, as though he’d just had seven cups of coffee, and a fatigue so profound that he could hardly get off

by Noaidi 2mo ago

From the article: “He’d waffle between jittery agitation, as though he’d just had seven cups of coffee, and a fatigue so profound that he could hardly get off the living room couch.” “I was convinced I’d come down with some severe condition that was going to kill me,” he says. For the next two years, Roes’s life became a series of waiting rooms and tests: blood work, brain scans, heart screenings. “I was having severe fevers and extreme phases where I would go into such a brain fog, I thought I might black out,” he says. The tests yielded no definitive diagnosis. — I have lived this myself. I’m not an ultra runner but many of these symptoms These runners have I have without ever being into exercise. And it runs in my family. They keep finding little weird things in my test results, but it’s never anything that leads to a diagnosis or affect. They label me with a psychological disorder only. I’m inclined to think that both my issue and these runners issues has to do with how they handle oxidative stress and the damage that can do to the neurological system. We know these runners are fueled by a sort of addiction to the running. And that’s going to involve dopamine. But since you have to metabolize dopamine using monoamine oxidize enzymes, you’re going to create hydrogen peroxide, and oxidative stressor, as a product. In my opinion to understand, neurological disorders, you need to understand how oxidative stress damages the neurons and the immune system. And it seems by even just thinking about this I was right I just googled over training and oxidative stress and came up with this paper https://pmc.ncbi.nlm.nih.gov/articles/PMC3435910/ https://pmc.ncbi.nlm.nih.gov/articles/PMC3435910/ The four theories of the disorder from the same magazine, which includes oxidated distress as one of them https://www.outsideonline.com/health/training-performance/overtraining-theories-study-oxidative-stress/ https://www.outsideonline.com/health/training-performance/ov... So I’m assuming the people this affects probably have some mild genetic issue that makes them a little bit worse at handling oxidative stress of some sort. This could be with glutathione peroxide or catalyze or any of the nutrients needed for us to absorb the cofactors that enable us to get rid of oxidative stress.

tsimionescu 2mo ago
There are so many things going on at the same time in the body of someone pushing themselves so far beyond human limits that it seems extremely unlikely you'd find a single neat cause for this. The bottom line is that they're destroying their bodies for athletic achievement, and most likely one too many things are pushed beyond a limit. The cure, or at least prevention, for them is simple - they should just stop doing this to themselves. The fact that the vague array of symptoms matches your own possibly genetic symptoms doesn't mean much, most likely. Perhaps there are some similar biological mechanisms behind at least some of it, but perhaps not.
- Noaidi 2mo ago
  Of course, yes. I feel like the only solution to these odd disorders lay in personalized medicine. I feel like only looking at their genome will reveal the true cause and wills how the genetics that put them at risk. But theer could be some other environmental variables as well. But they share enough of the same symptoms that they have already seemed to have narrowed it down to four possible causes. I never gave up on myself and I have come a long way, so I have hope for them.
nradov 2mo ago
Oxidative stress could be a factor in some cases but connecting that to dopamine metabolism seems like a real stretch.
- Noaidi 2mo ago
  A real stretch you say? Meaning that it’s something that they definitely would not study at all? https://pubmed.ncbi.nlm.nih.gov/1601559/ https://pubmed.ncbi.nlm.nih.gov/1601559/ When training is effective or the athletes are not exhausted, the decrease of the excretion rate--with the exception of dopamine--is more likely to be lower (noradrenaline, adrenaline). Generalization of these results requires further expansion of the experimental basis. Editing to add a more recent study(2025): https://www.sciencedirect.com/science/article/pii/S2666337625000174 https://www.sciencedirect.com/science/article/pii/S266633762... "Oestradiol, total catecholamines and dopamine levels were higher in OTS athletes." The more catecholamines you release the more H2O2 you will produce. And this one(2025): https://pmc.ncbi.nlm.nih.gov/articles/PMC12010411/pdf/main.pdf https://pmc.ncbi.nlm.nih.gov/articles/PMC12010411/pdf/main.p... Oxidative stress, mitochondrial damage, and inflammation create an environment in which DNA damage can occur. The results of animal studies have shown that overtraining can cause DNA damage in blood, skeletal muscle, and liver.

by Noaidi 2mo ago

tsimionescu 2mo ago

There are so many things going on at the same time in the body of someone pushing themselves so far beyond human limits that it seems extremely unlikely you'd find a single neat cause for this. The bottom line is that they're destroying their bodies for athletic achievement, and most likely one too many things are pushed beyond a limit. The cure, or at least prevention, for them is simple - they should just stop doing this to themselves. The fact that the vague array of symptoms matches your own possibly genetic symptoms doesn't mean much, most likely. Perhaps there are some similar biological mechanisms behind at least some of it, but perhaps not.

Noaidi 2mo ago
Of course, yes. I feel like the only solution to these odd disorders lay in personalized medicine. I feel like only looking at their genome will reveal the true cause and wills how the genetics that put them at risk. But theer could be some other environmental variables as well. But they share enough of the same symptoms that they have already seemed to have narrowed it down to four possible causes. I never gave up on myself and I have come a long way, so I have hope for them.

nradov 2mo ago

Oxidative stress could be a factor in some cases but connecting that to dopamine metabolism seems like a real stretch.

Noaidi 2mo ago
A real stretch you say? Meaning that it’s something that they definitely would not study at all? https://pubmed.ncbi.nlm.nih.gov/1601559/ https://pubmed.ncbi.nlm.nih.gov/1601559/ When training is effective or the athletes are not exhausted, the decrease of the excretion rate--with the exception of dopamine--is more likely to be lower (noradrenaline, adrenaline). Generalization of these results requires further expansion of the experimental basis. Editing to add a more recent study(2025): https://www.sciencedirect.com/science/article/pii/S2666337625000174 https://www.sciencedirect.com/science/article/pii/S266633762... "Oestradiol, total catecholamines and dopamine levels were higher in OTS athletes." The more catecholamines you release the more H2O2 you will produce. And this one(2025): https://pmc.ncbi.nlm.nih.gov/articles/PMC12010411/pdf/main.pdf https://pmc.ncbi.nlm.nih.gov/articles/PMC12010411/pdf/main.p... Oxidative stress, mitochondrial damage, and inflammation create an environment in which DNA damage can occur. The results of animal studies have shown that overtraining can cause DNA damage in blood, skeletal muscle, and liver.