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> I think the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place? That's pretty easy: The last cent

> I think the real question with Ozempic is.....why are so many bodies not producing enough natural GLP-1 in the first place? That's pretty easy: The last centuries (or decades, mostly) have provided an asymmetry in nutrition systems. Modern food engineering has optimized most of what people eat to have them crave more instead of being mainly filling. There is little to counter that, and GLP-1 is a way to do that. Another way is will power. Yet another is fixing what and how you eat (and how you exercise, but that'a a different topic).

Melatonic 2mo ago
Exactly. And that last one is the most important for long term results. Plus it's not like you couldn't combine a GLP-1 drug with great diet and exercise
- JumpCrisscross 2mo ago
  > that last one is the most important for long term results Empirically untrue. GLP-1s outperform diet and exercise alone. > it's not like you couldn't combine a GLP-1 drug with great diet and exercise This is how it's recommended to be taken. I personally know folks who were able to start regularly exercising and eating healthily because of the head start GLP-1s gave them. (They're mostly off them now, and they're all materially lighter and healthier than they were before.)
  - teiferer 2mo ago
    > Empirically untrue. GLP-1s outperform diet and exercise alone. Didn't you just contradict yourself? Short term, sure. GP didn't claim anything about short term and in the quote you pasted explicitly wrote "long term". For long term you said yourself that the drug, after the head start it gives, is not needed if proper food and exercise are in place.
- kube-system 2mo ago
  Diet and exercise guidance is the standard of care for prescribing GLP1s. But prescribing diet and exercise alone has long had mixed results, because it does nothing to address appetite, and it is even quite common for exercise to increase it.
  - teiferer 2mo ago
    True, but again, that's because lots of food is engineered to make you crave more, creating the asymmetry Not all food though, and if that's compensated for the the results are less mixed. (The temptation is constant and real though.)

Melatonic 2mo ago

Exactly. And that last one is the most important for long term results. Plus it's not like you couldn't combine a GLP-1 drug with great diet and exercise

JumpCrisscross 2mo ago
> that last one is the most important for long term results Empirically untrue. GLP-1s outperform diet and exercise alone. > it's not like you couldn't combine a GLP-1 drug with great diet and exercise This is how it's recommended to be taken. I personally know folks who were able to start regularly exercising and eating healthily because of the head start GLP-1s gave them. (They're mostly off them now, and they're all materially lighter and healthier than they were before.)
- teiferer 2mo ago
  > Empirically untrue. GLP-1s outperform diet and exercise alone. Didn't you just contradict yourself? Short term, sure. GP didn't claim anything about short term and in the quote you pasted explicitly wrote "long term". For long term you said yourself that the drug, after the head start it gives, is not needed if proper food and exercise are in place.
kube-system 2mo ago
Diet and exercise guidance is the standard of care for prescribing GLP1s. But prescribing diet and exercise alone has long had mixed results, because it does nothing to address appetite, and it is even quite common for exercise to increase it.
- teiferer 2mo ago
  True, but again, that's because lots of food is engineered to make you crave more, creating the asymmetry Not all food though, and if that's compensated for the the results are less mixed. (The temptation is constant and real though.)