3 ms·

I had the same intuition as you but I looked it up in light of GP's comment and it actually seems not so clear that's how it works. Apparently the physiological

I had the same intuition as you but I looked it up in light of GP's comment and it actually seems not so clear that's how it works. Apparently the physiological effects of prescription ADHD meds will tend to still be ~same intensity for years and years. Patients often report weakened cognitive/psychological effectiveness, but obviously that's very hard to compare...

disgruntledphd2 3mo ago
> Apparently the physiological effects of prescription ADHD meds will tend to still be ~same intensity for years and years. I'm not sure how one would even measure this. Like, back in the halcyon days of my youth I took a bunch of stimulants, and experentially there was definitely less impact over time (habituation is a thing). And given that ADHD is predominantly a psychological issue, then the only measure that matters is that of the patients themselves. Do you have some of the sources you mentioned available, I'd be interested to understand the details?
- astrange 2mo ago
  > Like, back in the halcyon days of my youth I took a bunch of stimulants, and experentially there was definitely less impact over time (habituation is a thing). That's magnesium deficiency. Promise. (Or side effects from getting worse sleep.)
  - disgruntledphd2 2mo ago
    > That's magnesium deficiency. Promise. I find that incredibly hard to believe (although my doctor did mention that magnesium supplements were worth taking). Can you point me to some research that support this claim please?
    - aw3glp1app 2mo ago
      [flagged]
treis 3mo ago
Practical experience is that people cycle through ADHD and depression meds. I agree that it's hard to tell what that means because we don't generally do long term double blind placebo studies.
- estearum 3mo ago
  The issue here is more complicated than just a lack of long term RCTs. It's that we're talking about psychological acclimation within individuals. Given that people's lives change so much, even within an RCT design it's not clear how you get an actual comparison of "effectiveness" from year 0 to year 4.
  - disgruntledphd2 3mo ago
    > t's not clear how you get an actual comparison of "effectiveness" from year 0 to year 4. You'd probably need a few different measures of attention/executive function and you'd need to counterbalance them across people to prevent habituation. Given that the regulatory bodies don't require studies like this, it's unlikely to ever happen.

disgruntledphd2 3mo ago

> Apparently the physiological effects of prescription ADHD meds will tend to still be ~same intensity for years and years. I'm not sure how one would even measure this. Like, back in the halcyon days of my youth I took a bunch of stimulants, and experentially there was definitely less impact over time (habituation is a thing). And given that ADHD is predominantly a psychological issue, then the only measure that matters is that of the patients themselves. Do you have some of the sources you mentioned available, I'd be interested to understand the details?

astrange 2mo ago
> Like, back in the halcyon days of my youth I took a bunch of stimulants, and experentially there was definitely less impact over time (habituation is a thing). That's magnesium deficiency. Promise. (Or side effects from getting worse sleep.)
- disgruntledphd2 2mo ago
  > That's magnesium deficiency. Promise. I find that incredibly hard to believe (although my doctor did mention that magnesium supplements were worth taking). Can you point me to some research that support this claim please?
  - aw3glp1app 2mo ago
    [flagged]

treis 3mo ago

Practical experience is that people cycle through ADHD and depression meds. I agree that it's hard to tell what that means because we don't generally do long term double blind placebo studies.

estearum 3mo ago
The issue here is more complicated than just a lack of long term RCTs. It's that we're talking about psychological acclimation within individuals. Given that people's lives change so much, even within an RCT design it's not clear how you get an actual comparison of "effectiveness" from year 0 to year 4.
- disgruntledphd2 3mo ago
  > t's not clear how you get an actual comparison of "effectiveness" from year 0 to year 4. You'd probably need a few different measures of attention/executive function and you'd need to counterbalance them across people to prevent habituation. Given that the regulatory bodies don't require studies like this, it's unlikely to ever happen.