3 ms·

Have any studies been done on this particular psychedelic? I'm curious.

throawayonthe 2mo ago
https://en.wikipedia.org/wiki/5-MeO-DMT https://en.wikipedia.org/wiki/5-MeO-DMT has some references and the "further reading" links might have way more
ulrikrasmussen 2mo ago
Most recent I know of: https://www.psychiatrictimes.com/view/blp-003-for-treatment-resistant-depression-phase-2b-patient-enrollment-completed https://www.psychiatrictimes.com/view/blp-003-for-treatment-... Mebufotenin is 5-MeO-DMT
john_strinlai 2mo ago
plenty of scientific and not-really-scientific links available at erowid for 5-meo-dmt https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml scientific references specifically at https://www.erowid.org/references/refs.php?S=5meo_dmt https://www.erowid.org/references/refs.php?S=5meo_dmt
Aurornis 2mo ago
A couple groups are trying to commercialize it. There have been some trials, but they're all relatively limited by depression trial standards. Double-blind is impossible because the participants know 100% if they've received it or not. Someone volunteering to sign up for a depression study to receive psychedelic drugs is probably a believer that they work, so the placebo groups end up disappointed and the active groups are happy they got assigned the psychedelic they signed up. One of the latest studies: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2846834 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/... They followed participants for 8 days, which is pretty disappointing. They really need to follow people for several months to see if anything holds or if it's a short-term placebo effect that wears off.
- eleveriven 2mo ago
  This seems like one of those areas where "double-blind randomized trial" sounds much cleaner on paper than it actually is. If nearly everyone can tell whether they got the drug, expectancy becomes a pretty nasty confound
pantalaimon 2mo ago
It's 5-MeO-DMT, better to synthesize it than to exploit the toads for it though. https://youtu.be/qipKKBmY_LQ https://youtu.be/qipKKBmY_LQ
- dylan604 2mo ago
  In the DMT world, carts are being sold known as Toad with the 5-MeO-DMT. Lots of very unhappy customers when they are not expecting it.
  - foobiekr 2mo ago
    I wish this was true in the Bay Area. 5-MeO-DMT does not seem to be available and it’s supposedly a unique experience.
    - NDlurker 2mo ago
      Start going to festivals?
    - pixel_popping 2mo ago
      You can just order domestic US.
  - temp0826 2mo ago
    I seriously don't know who would be unhappy about it. Pure 5-meo is a more reliable experience and no endangered toads need to be harmed. I don't know that one would even be able to liquify straight bufo properly to put in a cart for one...also pure 5-meo is maybe 3-5x more potent per weight so that probably makes it all easier too. Anyone pulling the "butttt it's unnaturalllll" card on this one is a fool.
    - throwup238 2mo ago
      Is anyone even getting it from toads anymore? 20 years ago it was cheap to synthesize and get from the research chemical market along with the 2Cs and friends. I haven’t done any drugs in a decade so I don’t know how hard it is to get now but I doubt an enterprising internet sleuth would have a hard time finding a source.

https://en.wikipedia.org/wiki/5-MeO-DMT https://en.wikipedia.org/wiki/5-MeO-DMT has some references and the "further reading" links might have way more

ulrikrasmussen 2mo ago

Most recent I know of: https://www.psychiatrictimes.com/view/blp-003-for-treatment-resistant-depression-phase-2b-patient-enrollment-completed https://www.psychiatrictimes.com/view/blp-003-for-treatment-... Mebufotenin is 5-MeO-DMT

john_strinlai 2mo ago

plenty of scientific and not-really-scientific links available at erowid for 5-meo-dmt https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml https://www.erowid.org/chemicals/5meo_dmt/5meo_dmt.shtml scientific references specifically at https://www.erowid.org/references/refs.php?S=5meo_dmt https://www.erowid.org/references/refs.php?S=5meo_dmt

Aurornis 2mo ago

A couple groups are trying to commercialize it. There have been some trials, but they're all relatively limited by depression trial standards. Double-blind is impossible because the participants know 100% if they've received it or not. Someone volunteering to sign up for a depression study to receive psychedelic drugs is probably a believer that they work, so the placebo groups end up disappointed and the active groups are happy they got assigned the psychedelic they signed up. One of the latest studies: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2846834 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/... They followed participants for 8 days, which is pretty disappointing. They really need to follow people for several months to see if anything holds or if it's a short-term placebo effect that wears off.

eleveriven 2mo ago
This seems like one of those areas where "double-blind randomized trial" sounds much cleaner on paper than it actually is. If nearly everyone can tell whether they got the drug, expectancy becomes a pretty nasty confound

pantalaimon 2mo ago

It's 5-MeO-DMT, better to synthesize it than to exploit the toads for it though. https://youtu.be/qipKKBmY_LQ https://youtu.be/qipKKBmY_LQ

dylan604 2mo ago
In the DMT world, carts are being sold known as Toad with the 5-MeO-DMT. Lots of very unhappy customers when they are not expecting it.
- foobiekr 2mo ago
  I wish this was true in the Bay Area. 5-MeO-DMT does not seem to be available and it’s supposedly a unique experience.
  - NDlurker 2mo ago
    Start going to festivals?
  - pixel_popping 2mo ago
    You can just order domestic US.
- temp0826 2mo ago
  I seriously don't know who would be unhappy about it. Pure 5-meo is a more reliable experience and no endangered toads need to be harmed. I don't know that one would even be able to liquify straight bufo properly to put in a cart for one...also pure 5-meo is maybe 3-5x more potent per weight so that probably makes it all easier too. Anyone pulling the "butttt it's unnaturalllll" card on this one is a fool.
  - throwup238 2mo ago
    Is anyone even getting it from toads anymore? 20 years ago it was cheap to synthesize and get from the research chemical market along with the 2Cs and friends. I haven’t done any drugs in a decade so I don’t know how hard it is to get now but I doubt an enterprising internet sleuth would have a hard time finding a source.