5 ms·
Scientists reverse brain aging, with a nasal spray
- amingilani 3mo ago...in mice. > Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age. — https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70232 https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
- doginasuit 3mo agoTo be fair though, I think we owe the mice a positive research outcome.
- antonvs 3mo ago“Congratulations, you get improved brain function while we continue to run other experiments on you!”
- earthnail 3mo ago“There will be cake!”
- ghurtado 3mo agoYou can now experience both physical pain and existential dread!
- tryagainian 3mo agoOn the plus side, expect to see great works of literature authored by rodents.
- switchbak 3mo agoThat PR piece was brutal to navigate. Undoubtedly punched up by AI, it took far too long to even understand what the treatment entailed.
- SubiculumCode 3mo agoThe link to the actual paper was appreciated. The context of whether findings will generalize outside of mouse models can depend a lot on specifics of the problem.
- fuckinpuppers 3mo agoMice get all the cool shit first
- secretslol 3mo agoI even seen a mouse on youtube with it's own tiny EV sports car driving about!
- dlcarrier 3mo agoI read a book about a mouse with a motorcycle (https://www.goodreads.com/en/book/show/232109.The_Mouse_and_the_Motorcycle https://www.goodreads.com/en/book/show/232109.The_Mouse_and_...) and a different book about a mouse-like child with sailboat. (https://www.goodreads.com/en/book/show/138959.Stuart_Little https://www.goodreads.com/en/book/show/138959.Stuart_Little). M. Night Shyamalan wrote a screenplay about the latter book, and it was made into a popular movie.
- tryagainian 3mo agoThis one? https://youtube.com/shorts/E74r-ybeQfE https://youtube.com/shorts/E74r-ybeQfE Someone needs to put an octopus in a mini vehicle.
- secretslol 3mo agoThat's the one. I used a bit of creative freedom when describing a mouse with an EV sports car; it was a rat and an EV taxi.
- tryagainian 3mo agoClose enough
- jjtheblunt 3mo agothey get all the worst and most inane tortures too
- 3mo ago
- earth-tattoo 3mo agoThat's exactly what I want: immortal mice!
- ghurtado 3mo agoThat's a surprisingly underused plot for a sci Fi horror film. Considering the grand total of experiments we've ran on the little guys, I'm kinda surprised we haven't bred Mousezilla yet
- dlcarrier 3mo agoYou joke, but rodents make great pets, because they are very social and have a range of personalities, but most only live a few years. I knew someone with a pet retired lab rat, and it lived much longer than the average fancy rat, but even then, it didn't even live half as long as the average cat or dog. If we could breed or treat rodents to live longer, we could keep low-resource pets without as much loss.
- magpi3 3mo agoThere is an excellent "This American Life" episode on rats. The first act is about a guy who keeps rats as pets. It's a sweet story. https://www.thisamericanlife.org/801/transcript https://www.thisamericanlife.org/801/transcript
- SubiculumCode 3mo agoHigh impact journal for an interesting study that is admittedly largely out of my area of expertise. The limitation of it being done in animal models, is of course, noted, but also expected. The question I would ask is how well the underlying background research makes this outcome expected.
- jskeicjwkxjwkd 3mo agoDamn, that’s one hell of a way to say “is this any good though?”. Too many words for such a simple question.
- SubiculumCode 3mo agoPretty much, lol. I started to say some other things but decided to say less.
- Brian_K_White 3mo agoBut "how well the underlying background research makes this outcome expected" does not mean "is this any good though". It's also an actually interesting question. It's one thing to find some things hard to follow, it's another to be proud of it.
- block_dagger 3mo agoFlowers for Algernon’s Brain
- wingmanjd 3mo agoThis short story was scarier to me as a kid than anything else I read at the time.
- bookofjoe 3mo agoThe movie adaptation — “Charlie” — is heartbreakingly good.
- jb1991 3mo agoThis one? Not called “Charlie” https://www.imdb.com/title/tt0210044/ https://www.imdb.com/title/tt0210044/
- bookofjoe 3mo agoThat's a 2000 remake of the 1968 film. Also, I misspelled the title: It's "Charly" https://youtu.be/ddtNxb43yYo?si=XnXdl1J-w3NjHXQq https://youtu.be/ddtNxb43yYo?si=XnXdl1J-w3NjHXQq
- flintapi 3mo ago[flagged]
- gavinray 3mo ago"Reverse brain aging", sure, in the same sense that taking Vitamin C reverses aging. The nasal spray reduced markers of inflammation in hippocampal microglial cells. A lot of things reduce inflammation. That is not "reversing ageing". Of course, "reduces inflammation" doesn't headline very well...
- mawadev 3mo agoThe article is also heavily ai generated, I call bs on every single bit
- scrubs 3mo agoAI generated? Not demonstrated. Whining by humans claiming AI? Predictable. Probable. Indeed LLM "complete the sentence" predictable.
- fwip 3mo agoSure, a human could be deliberately trying to sound like AI writing, or perhaps they've spent so much time reading it that they think it's normal.
- dwa3592 3mo agoc'mon you guys, chill. this is not a vaccine.
- bigmattystyles 3mo agoI thought the url said temu at first.
- RyanOD 3mo agoHah! Me too.
- rylando 3mo agoKinda surprised A&M’s letting them use AI to write these things
- general_reveal 3mo agoWhen can I snort this?
- hoppp 3mo agoPrepare a line for me also please
- tryagainian 3mo agoGrab me a bag while your there.
- grg0 3mo agoI knew cocaine had to have an upside.
- hoppp 3mo agoI take N-acetylcysteine and it helps with brain fog also! Plus it reduces stress and irritability.
- ai_fry_ur_brain 3mo agoAnd OCD symptoms, and many also benefit from better impulse control. Its more effective than SSRIs for some. NAC is one of the only known treatments for trichotillomania, a under discussed but common condition that causes people to uncontrollably pull their hair out. NAC has also been studied to reduce nicotine and alchohol cravings as well.
- aurareturn 3mo agoWhat is your dosage?
- ai_fry_ur_brain 3mo agoI take 1200mg a day, when Im taking it. I think standard/reccomended dosage is 600mg.
- aurareturn 3mo agoWhat's the reason to take it everyday? Does it truly make a difference everyday or could you get away with 1/3 days? What are the effects on you?
- keepamovin 3mo agoUgh, I thought we were done with the Boomers....looks like they're gonna hang on.
- timmg 3mo agoHow soon until biohackers try this on themselves?
- lioeters 3mo agoThe failure scenarios are fun to imagine, like uncontrollable brain growth or waking nightmares as weird side effect of centuries-old brain.
- catlifeonmars 3mo agoTFA reeks of over-sensationalizing. Here is a summary sans hyperbole: Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus[1]. Abstract: > Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age-related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide-binding domain, leucine-rich repeat family, and pyrin domain-containing 3 (NLRP3) inflammasomes, and the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway that triggers type 1 interferon (IFN-1) signalling. Studies have shown that extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) contain therapeutic miRNAs that can alleviate neuroinflammation. Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age. Compared with animals receiving vehicle treatment, the hippocampus of animals receiving hiPSC-NSC-EVs exhibited reductions in astrocyte hypertrophy, microglial clusters, and oxidative stress, along with elevated expression of antioxidant proteins and genes that maintain mitochondrial respiratory chain integrity. Moreover, hiPSC-NSC-EVs therapy decreased the levels of various proteins involved in the activation of the NLRP3 inflammasome, p38/mitogen-activated protein kinase, cGAS-STING-IFN-1, and Janus kinase and signal transducer and activator of transcription signalling pathways. Furthermore, in vitro assays using genetically engineered RAW cells and hiPSC-NSC-EVs, with or without targeted depletion of specific miRNAs, demonstrated that miRNA-30e-3p and miRNA-181a-5p, both present in hiPSC-NSC-EVs, can significantly inhibit the activation of the NLRP3 inflammasome and the STING pathway, respectively. Additionally, single-cell RNA sequencing conducted 7 days post-treatment revealed that hiPSC-NSC-EVs induce widespread transcriptomic changes in microglia, including increased expression of numerous genes that enhance oxidative phosphorylation and reduced expression of abundant genes that drive multiple proinflammatory signalling pathways. These changes mediated by hiPSC-NSC-EVs were also associated with improved cognitive and memory function. Thus, intranasal hiPSC-NSC-EVs therapy in late middle age can effectively diminish proinflammatory microglial transcriptome and signalling cascades that drive neuroinflammaging in the hippocampus, contributing to better brain function in old age. [1]: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.70232 https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
- Joel_Mckay 3mo agoMany Brain-aging study sample pools are from young folks that died in accidents, aged homeless alcoholics, and individuals that were in declining health. Most cultures find it taboo to donate their beloved family members bodies for scientific dissection. Thus, people get ingrained "[bigotry] with extra steps" similar to phrenology proponents. https://en.wikipedia.org/wiki/Simpson%27s_paradox https://en.wikipedia.org/wiki/Simpson%27s_paradox "Old age and treachery will always beat youth and exuberance" =3
- huflungdung 3mo ago[dead]
- deleted 3mo ago[deleted]
- ChrisArchitect 3mo agoStory from April; Some previous discussion: https://news.ycombinator.com/item?id=48288478 https://news.ycombinator.com/item?id=48288478
- Alien1Being 3mo agoTemu science at Tamu. I have an AI generated bridge that I can sell you...