5 ms·

It's only a matter of time before nootropics forums start experimenting with these drugs... These drugs seem to change something fundamental that reduces probl

It's only a matter of time before nootropics forums start experimenting with these drugs... These drugs seem to change something fundamental that reduces problematic behavior.

toomuchtodo 4mo ago
n=1, tirzepatide puts my brain into "neutral," [1] I do not have strong feelings anymore on most anything not "fight or flight." Ego death via GLP-1 if you will. Probably has something to do with how it patches the reward center and its link to impulsive behavior in the prefrontal cortex [2]. [1] https://www.youtube.com/watch?v=SSEjPuR11_k https://www.youtube.com/watch?v=SSEjPuR11_k [2] Diekhof EK, Nerenberg L, Falkai P, Dechent P, Baudewig J, Gruber O. Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control. Hum Brain Mapp. 2012 Dec;33(12):2768-84. doi: https://doi.org/10.1002/hbm.21398 https://doi.org/10.1002/hbm.21398 Epub 2011 Sep 21. PMID: 21938756; PMCID: PMC6870517.
- asdff 4mo ago
  It is kind of interesting the implications of "making you feel less hungry" in terms of a general insensitivity to the bodies own signalling mechanisms, vs just a hyper convenient targeted approach that only strikes the hunger portion of the dopamine-reward mechanism. I wonder if you can do a simple experiment between glp and non glp users where you try and measure various biological response to giving someone say $20? Going further I wonder if it affects other responses like pain response. How long might you keep your hand on a plate warming up? I seem to remember that sort of experimental setup in my undergrad days of signing up for every psychology department experiment under the sun for beer money.
JuniperMesos 4mo ago
The sorts of people who are on nootropics forums are definitely already experimenting with GLP-1 agonists and have been for a long time now.
- red-iron-pine 4mo ago
  yeah its been on their radar long before it was a popular discussion topic. it's just not as dramatic or memeable as doing small amounts of LSD
coldtea 4mo ago
What if you can't reduce problematic behavior without also reducing desirable behavior (like motivation)?

It's only a matter of time before nootropics forums start experimenting with these drugs... These drugs seem to change something fundamental that reduces problematic behavior.

toomuchtodo 4mo ago

n=1, tirzepatide puts my brain into "neutral," [1] I do not have strong feelings anymore on most anything not "fight or flight." Ego death via GLP-1 if you will. Probably has something to do with how it patches the reward center and its link to impulsive behavior in the prefrontal cortex [2]. [1] https://www.youtube.com/watch?v=SSEjPuR11_k https://www.youtube.com/watch?v=SSEjPuR11_k [2] Diekhof EK, Nerenberg L, Falkai P, Dechent P, Baudewig J, Gruber O. Impulsive personality and the ability to resist immediate reward: an fMRI study examining interindividual differences in the neural mechanisms underlying self-control. Hum Brain Mapp. 2012 Dec;33(12):2768-84. doi: https://doi.org/10.1002/hbm.21398 https://doi.org/10.1002/hbm.21398 Epub 2011 Sep 21. PMID: 21938756; PMCID: PMC6870517.

asdff 4mo ago
It is kind of interesting the implications of "making you feel less hungry" in terms of a general insensitivity to the bodies own signalling mechanisms, vs just a hyper convenient targeted approach that only strikes the hunger portion of the dopamine-reward mechanism. I wonder if you can do a simple experiment between glp and non glp users where you try and measure various biological response to giving someone say $20? Going further I wonder if it affects other responses like pain response. How long might you keep your hand on a plate warming up? I seem to remember that sort of experimental setup in my undergrad days of signing up for every psychology department experiment under the sun for beer money.

JuniperMesos 4mo ago

The sorts of people who are on nootropics forums are definitely already experimenting with GLP-1 agonists and have been for a long time now.

red-iron-pine 4mo ago
yeah its been on their radar long before it was a popular discussion topic. it's just not as dramatic or memeable as doing small amounts of LSD

coldtea 4mo ago

What if you can't reduce problematic behavior without also reducing desirable behavior (like motivation)?