https://xcancel.com/OpenAI/status/2067293746556027376 https://xcancel.com/OpenAI/status/2067293746556027376 GPT-5.4 reviewed scientific literature, generated a

https://xcancel.com/OpenAI/status/2067293746556027376 https://xcancel.com/OpenAI/status/2067293746556027376 GPT-5.4 reviewed scientific literature, generated and ranked research proposals, helped design experiments, analyzed results, and proposed follow-up studies. Human chemists steered the work, selected proposals for testing, and validated the final result. Maria [AI] tested the idea across 10,080 reactions, and human chemists later validated representative results by hand. Under the optimized conditions, yields improved for 88% of the boronic acids and 83% of the sulfonamides tested. Human chemists then repeated 14 representative reactions by hand: 11 showed higher yields, including 8 with a more than twofold improvement. The full process took about 2.5 months, plus another half month for human chemists to write up the results.