3 ms·
> More than 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene. So panc
by siva7 4mo ago
> More than 90% of patients with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (mPDAC), have a mutation in the Kras gene.
So pancreatic cancer is basically a genetic disease for most patients instead of environmental?
- roadnottaken 4mo agoNo, the KRAS mutations are somatic (spontaneous), not inherited
- AustinDev 4mo agoSo presumably something causes the spontaneous mutations?
- M95D 4mo agoNature. DNA is unstable. Lots of stuff cause mutations: background radiation, chemicals, viruses, even our own normal metabolism [1]. [1] https://en.wikipedia.org/wiki/Reactive_oxygen_species#Oxidative_damage https://en.wikipedia.org/wiki/Reactive_oxygen_species#Oxidat...