3 ms·
“The conception before was that, when it came to nucleosomes, genes were either turned on or off, but we’re finding it’s more like a volume dial,” this is not
by rolph 6mo ago
“The conception before was that, when it came to nucleosomes, genes were either turned on or off, but we’re finding it’s more like a volume dial,”
this is not a new paradigm. this was apparent in the late 80s.
modulation of DNA / nucleosomal binding affinity, is a known epigenetic mechanism for the last 35 years.
DNA expressivity is not digital, its result of many affinity based interactions over time contributing to a summary result in the form of conformational change or rate of reaction.
- themafia 6mo ago> “Our findings suggest that the genome is far more dynamic and accessible than the scientific community realized,” Ramani says. My findings suggest that "AI researchers" generally ignore all existing discoveries so they can make outlandish claims about the novelty of their work.
- sitkack 6mo agoAlso renaming established concepts, for novelty.
- calmbonsai 6mo agoAgreed. This seems like an "institute publishing" re-hash purely for marketing purposes. I see nothing novel in the paper.