4 ms·

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb B

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10 weeks, so I suspect thats why I lost muscle mass :/

twodave 6mo ago
Did you work out during those 10 weeks any? TBH if you went from regular lifting to not for 10 weeks I'd expect a similar decrease in your lifting numbers (though not a .4lb/day weight loss of course)
- tbojanin 6mo ago
  I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)
hammock 6mo ago
Those are sizable drops for 10 weeks unless you stopped lifting as well
- tbojanin 6mo ago
  Mentioned above, but "I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)"
cheald 6mo ago
I used a combo of low-dose retatrutide, tesamorelin, and ipamorelin and lost about 15lb over 45 days, including 60% of my visceral fat, and put on 4lb of muscle, per before-and-after DEXA scans. I lifted regularly, ate well, and prioritized protein, and while I definitely under-ate protein, I was very pleased to find that I was able to increase muscle mass while cutting the fat. My visceral fat was the primary target here, since I'd been unable to get it to budge despite consistent training and diet. Very pleased.
olalonde 6mo ago
You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.
- rootusrootus 6mo ago
  Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.
  - olalonde 6mo ago
    Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/ https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.
    - staticassertion 6mo ago
      > because it is known to I thought that this was not yet substantiated in human trials? There's a plausible mechanism and, I think a mouse trial, right?
      - olalonde 6mo ago
        Seems you are correct according to https://pubmed.ncbi.nlm.nih.gov/40609566/ https://pubmed.ncbi.nlm.nih.gov/40609566/: "The proportion of lean mass loss to weight loss was similar to other obesity treatments."
  - dcherman 6mo ago
    You need to define how much muscle mass you expect to lose. The entire idea behind the bulk/cut cycle is that you want to net gain muscle after a full diet cycle. It's also not borderline impossible to maintain the majority of your muscle mass, but it depends on how you eat and train. We don't know enough about the person above's diet, training, current body composition, etc. to say anything for certain.
jwpapi 6mo ago
solid bench brother
- tbojanin 6mo ago
  thank you:^)
renewiltord 6mo ago
Dude, you must be jacked. Great lifts at those weights. Unreal bench haha. Good shit, dude.
xarope 6mo ago
It's interesting you mention this (anhedonia), since the guardian just published this article: https://www.theguardian.com/science/2026/apr/06/is-retatrutide-experimental-weight-loss-drug-making-people-fall-out-of-love https://www.theguardian.com/science/2026/apr/06/is-retatruti... How did you actually feel? Disinterested in stuff, ennui, or other?
- tbojanin 6mo ago
  Yeah, basically disinterested. Somewhat burnt out from doing things I normally love doing such as going on walks, programming on weekends, gaming, and work. It wasn't a really big problem, I only noticed it when looking retroactively at my experience.
  - bradlys 6mo ago
    How much of that is just from your hormones being trashed due to a severe deficit? Large caloric deficits (1000+/day) in leaner people is known to tank T levels among other things. When I was on such large deficits, I had very weird mood/arousal swings. Nothing that problematic for someone with as much executive control as me but it was very weird to be held hostage to.
staticassertion 6mo ago
Even if you hadn't lost any muscle mass, zero chance you're going to see the same exercise performance on a calorie deficit.
- throwaway2037 6mo ago
  This is untrue. There are 100s of YouTube videos of amateur body builders preparing for a show. They are able to maintain their muscle mass while in a calorie deficit. Yes, it is insanely hard, but it can be done.
  - staticassertion 6mo ago
    I didn't say that you can't maintain muscle mass. I'm saying your performance will suffer.
throwaway2037 6mo ago
This is crazy. You lost 28 lbs (15% of your body weight) in 10 weeks. Why did your doctor to allow you to continue? By any common sense, that is an unhealthy pace to lose body weight.
- mft_ 6mo ago
  Why?
  - dmschulman 6mo ago
    Your internal organs can't keep up with that kind of mass fluctuation, for one. Keep an eye on your kidneys.
    - mft_ 6mo ago
      It seems to be more complicated (or unpredictable?) than that: > In this study, rapid weight loss was associated with the loss of kidney function in males with normal weight, and with improvement of kidney function in overweight males. > Our study showed that BMI and BMI change were not associated with eGFR change in females. https://pmc.ncbi.nlm.nih.gov/articles/PMC4658128/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4658128/
functional_dev 6mo ago
Did you try increasing protein intake during the cut?

twodave 6mo ago

Did you work out during those 10 weeks any? TBH if you went from regular lifting to not for 10 weeks I'd expect a similar decrease in your lifting numbers (though not a .4lb/day weight loss of course)

tbojanin 6mo ago
I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)

hammock 6mo ago

Those are sizable drops for 10 weeks unless you stopped lifting as well

tbojanin 6mo ago
Mentioned above, but "I worked out 6 days a week still, but swapped out 1 of my leg days for a run day (between 2-4 miles)"

cheald 6mo ago

I used a combo of low-dose retatrutide, tesamorelin, and ipamorelin and lost about 15lb over 45 days, including 60% of my visceral fat, and put on 4lb of muscle, per before-and-after DEXA scans. I lifted regularly, ate well, and prioritized protein, and while I definitely under-ate protein, I was very pleased to find that I was able to increase muscle mass while cutting the fat. My visceral fat was the primary target here, since I'd been unable to get it to budge despite consistent training and diet. Very pleased.

olalonde 6mo ago

You lost muscle because you lost around 1.54% of body weight per week, which is way too aggressive. The maximum recommended amount for losing weight while retaining muscle is around 1%. You will also most likely experience a weight rebound.

rootusrootus 6mo ago
Hasn't this mostly been debunked? You lose muscle mass because you lost mass overall, and whether you lost it too quickly or not is not the major factor. AFAIK maintaining muscle mass while losing fat is borderline impossible for anyone who isn't extremely fat and/or very disproportionate composition to begin with.
- olalonde 6mo ago
  Not as far as I know. The ratio of fat-to-muscle loss depends on several factors, most notably the rate of weight loss (see https://pubmed.ncbi.nlm.nih.gov/34371981/ https://pubmed.ncbi.nlm.nih.gov/34371981/). In fact, retatrutide is popular notably because it is known to preserve lean body mass better than other weight loss drugs.
  - staticassertion 6mo ago
    > because it is known to I thought that this was not yet substantiated in human trials? There's a plausible mechanism and, I think a mouse trial, right?
    - olalonde 6mo ago
      Seems you are correct according to https://pubmed.ncbi.nlm.nih.gov/40609566/ https://pubmed.ncbi.nlm.nih.gov/40609566/: "The proportion of lean mass loss to weight loss was similar to other obesity treatments."
- dcherman 6mo ago
  You need to define how much muscle mass you expect to lose. The entire idea behind the bulk/cut cycle is that you want to net gain muscle after a full diet cycle. It's also not borderline impossible to maintain the majority of your muscle mass, but it depends on how you eat and train. We don't know enough about the person above's diet, training, current body composition, etc. to say anything for certain.

jwpapi 6mo ago

solid bench brother

tbojanin 6mo ago
thank you:^)

renewiltord 6mo ago

Dude, you must be jacked. Great lifts at those weights. Unreal bench haha. Good shit, dude.

xarope 6mo ago

It's interesting you mention this (anhedonia), since the guardian just published this article: https://www.theguardian.com/science/2026/apr/06/is-retatrutide-experimental-weight-loss-drug-making-people-fall-out-of-love https://www.theguardian.com/science/2026/apr/06/is-retatruti... How did you actually feel? Disinterested in stuff, ennui, or other?

tbojanin 6mo ago
Yeah, basically disinterested. Somewhat burnt out from doing things I normally love doing such as going on walks, programming on weekends, gaming, and work. It wasn't a really big problem, I only noticed it when looking retroactively at my experience.
- bradlys 6mo ago
  How much of that is just from your hormones being trashed due to a severe deficit? Large caloric deficits (1000+/day) in leaner people is known to tank T levels among other things. When I was on such large deficits, I had very weird mood/arousal swings. Nothing that problematic for someone with as much executive control as me but it was very weird to be held hostage to.

staticassertion 6mo ago

Even if you hadn't lost any muscle mass, zero chance you're going to see the same exercise performance on a calorie deficit.

throwaway2037 6mo ago
This is untrue. There are 100s of YouTube videos of amateur body builders preparing for a show. They are able to maintain their muscle mass while in a calorie deficit. Yes, it is insanely hard, but it can be done.
- staticassertion 6mo ago
  I didn't say that you can't maintain muscle mass. I'm saying your performance will suffer.

throwaway2037 6mo ago

This is crazy. You lost 28 lbs (15% of your body weight) in 10 weeks. Why did your doctor to allow you to continue? By any common sense, that is an unhealthy pace to lose body weight.

mft_ 6mo ago
Why?
- dmschulman 6mo ago
  Your internal organs can't keep up with that kind of mass fluctuation, for one. Keep an eye on your kidneys.
  - mft_ 6mo ago
    It seems to be more complicated (or unpredictable?) than that: > In this study, rapid weight loss was associated with the loss of kidney function in males with normal weight, and with improvement of kidney function in overweight males. > Our study showed that BMI and BMI change were not associated with eGFR change in females. https://pmc.ncbi.nlm.nih.gov/articles/PMC4658128/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4658128/

functional_dev 6mo ago

Did you try increasing protein intake during the cut?