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> given I eat peptides every day from my food This is briefly addressed in the article, but basically it's one thing to eat a peptide and quite another thing t

> given I eat peptides every day from my food This is briefly addressed in the article, but basically it's one thing to eat a peptide and quite another thing to inject it. Your digestive system is extremely adroit at taking peptides and proteins and breaking them down into individual amino acids, which are then absorbed via "transporters" in the gut. (e.g. SLC6A14 for glutamate and cysteine.) If you eat insulin, absolutely nothing will happen. If you inject just a little bit too much, you're dead. So, generally: Ingested proteins/peptides aren't drug-like, whereas they can be extremely potent drugs if administered via injection. Granted, there are exceptions. If you accidentally get a drop of botox into your mouth, you'll be okay, but if you drink a vial, you'll be poisoned. And people have been trying to make orally-active peptides and proteins for decades, with some noteworthy successes, however few and far between in the general case.

Bender 7mo ago
I agree with some of this. There are most certainly orally active peptides such as BPC-157 and its replacement PDA penta deca arginate that can repair the gut and still circulate throughout the body especially in those with leaky gut. People with leaky gut should be able to buy a clean source of BPC-157 or PDA without a prescription and without visiting dark alleys. It is very safe and tolerable. GLP's are all the rage these days. Doctors seem to be giving GLP peptides out like candy and those are injected. People are looking like zombies. That said if doctors are going to be so liberal with them I should be able to buy it in the grocery store and slap it down on the conveyor belt. Again I can buy things far more dangerous than any prescription drug. There are very dangerous supplements, some that are shilled heavily on youtube. For example, Glycine (for me specifically used without a specific process) is more dangerous than heroine and the vast majority of doctors would have no idea what I am talking about.
- dc396 7mo ago
  > It is very safe and tolerable. Can you point to the clinical trials that demonstrate this? > Doctors seem to be giving GLP peptides out like candy and those are injected. There have been several _thousand_ clinical trials that have shown GLP-1s to be safe and effective.
  - XorNot 7mo ago
    Also LOL at the notion "peptides are safe because GLP-1 exists". Pretty much all venoms are mixes of short (10-15 base) peptide chains. It's the naturalistic fallacy in an utterly perverse form ( and also goes to show why a regulatory system is good: the average person has no idea that they're dealing with or even common sense about it).
    - flexagoon 7mo ago
      "Liquids are safe because water exists"
      - Bender 7mo ago
        FDA is a money sink. People basically bribe to get their own self tests approved much like the airlines have their own FAA inspectors that approve their own self tests under duress and bribes. It's all a scam and everyone here knows this even if they won't admit it. Nullify the FDA, FAA and at least half of the other orgs. Give at least half of those budgets to the people. Make aircraft smart enough to evade all obstacles. Make it technically damn near impossible to collide with anything. Make aircraft coordinate themselves. All doable. Force retire all FDA and FAA and give them a balloon, a golden wrist-watch and send them away. Give people an app to paste in all the things they take or plan to take in terms of foods, supplements, drugs, their allergies. Let the best AI figure out what will happen.
- fragmede 7mo ago
  Injected BPC-157 to a wound is a magic healing potion as far as I'm concerned. That it's not more broadly available is a crime, imo. If I had a billion dollars, I'd push so many things through the FDA.
  - solenoid0937 7mo ago
    If you had a billion dollars, you would need many billions more to push even a single thing through the FDA!
    - fragmede 7mo ago
      This is entirely theorical, but the $2.6 billion figure that's commonly quoted accounts for all the failures as well. If I took something that's proven in Europe but wouldn't get a patent, it presumably would manage to pass FDA regulations, it's just that without the patent protection, there's no financial incentive for an existing company to do that.
- deleted 7mo ago
  [deleted]
tshaddox 7mo ago
> > given I eat peptides every day from my food It’s also just a silly rhetorical technique. The ability to construct a grammatical sentence of that form does not constitute a valid argument. “Restricting nuclear material is silly given that nearly all the stuff I interact with every day contains atomic nuclei.”

Bender 7mo ago

I agree with some of this. There are most certainly orally active peptides such as BPC-157 and its replacement PDA penta deca arginate that can repair the gut and still circulate throughout the body especially in those with leaky gut. People with leaky gut should be able to buy a clean source of BPC-157 or PDA without a prescription and without visiting dark alleys. It is very safe and tolerable. GLP's are all the rage these days. Doctors seem to be giving GLP peptides out like candy and those are injected. People are looking like zombies. That said if doctors are going to be so liberal with them I should be able to buy it in the grocery store and slap it down on the conveyor belt. Again I can buy things far more dangerous than any prescription drug. There are very dangerous supplements, some that are shilled heavily on youtube. For example, Glycine (for me specifically used without a specific process) is more dangerous than heroine and the vast majority of doctors would have no idea what I am talking about.

dc396 7mo ago
> It is very safe and tolerable. Can you point to the clinical trials that demonstrate this? > Doctors seem to be giving GLP peptides out like candy and those are injected. There have been several _thousand_ clinical trials that have shown GLP-1s to be safe and effective.
- XorNot 7mo ago
  Also LOL at the notion "peptides are safe because GLP-1 exists". Pretty much all venoms are mixes of short (10-15 base) peptide chains. It's the naturalistic fallacy in an utterly perverse form ( and also goes to show why a regulatory system is good: the average person has no idea that they're dealing with or even common sense about it).
  - flexagoon 7mo ago
    "Liquids are safe because water exists"
    - Bender 7mo ago
      FDA is a money sink. People basically bribe to get their own self tests approved much like the airlines have their own FAA inspectors that approve their own self tests under duress and bribes. It's all a scam and everyone here knows this even if they won't admit it. Nullify the FDA, FAA and at least half of the other orgs. Give at least half of those budgets to the people. Make aircraft smart enough to evade all obstacles. Make it technically damn near impossible to collide with anything. Make aircraft coordinate themselves. All doable. Force retire all FDA and FAA and give them a balloon, a golden wrist-watch and send them away. Give people an app to paste in all the things they take or plan to take in terms of foods, supplements, drugs, their allergies. Let the best AI figure out what will happen.
fragmede 7mo ago
Injected BPC-157 to a wound is a magic healing potion as far as I'm concerned. That it's not more broadly available is a crime, imo. If I had a billion dollars, I'd push so many things through the FDA.
- solenoid0937 7mo ago
  If you had a billion dollars, you would need many billions more to push even a single thing through the FDA!
  - fragmede 7mo ago
    This is entirely theorical, but the $2.6 billion figure that's commonly quoted accounts for all the failures as well. If I took something that's proven in Europe but wouldn't get a patent, it presumably would manage to pass FDA regulations, it's just that without the patent protection, there's no financial incentive for an existing company to do that.
deleted 7mo ago
[deleted]

tshaddox 7mo ago

> > given I eat peptides every day from my food It’s also just a silly rhetorical technique. The ability to construct a grammatical sentence of that form does not constitute a valid argument. “Restricting nuclear material is silly given that nearly all the stuff I interact with every day contains atomic nuclei.”