4 ms·

Kind of makes sense that stopping taking a drug that reduces heart attack and stroke risk leads to a return to the higher risk of before.

ErroneousBosh 7mo ago
It doesn't reduce heart attack and stroke. It reduces appetite, kind of, and gives you a sore stomach while making you shit yourself inside out. All this can, with care, help contribute to weight loss. Weight loss can reduce heart attack and stroke, but GLP-1 does not. You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.
- malfist 7mo ago
  Your comment is all kinds of wrong. A) it does have cardio protective effects. It does reduce your appetite, and for most people have very few side effects. If you get nausea you're titrating up too fast. Most people, because it slows gastric emptying, it doesn't make them shit themselves "inside and out". GLP1s are a decent option for treating ibs-d or bile acid issues and is better tolerated than your bile acid sequesterants. > You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often. This victim blaming advice has been given for decades and obesity rates have been climbing for decades. Only glp-1s have reduced that.
- cthalupa 7mo ago
  We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight. Edit: In fact, from the study - BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted), Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)
  - ErroneousBosh 7mo ago
    Have you got a link to the study those figures are actually from? I'm not saying their wrong but I would like to read and understand them for myself before I change my mind. > BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted), So, what, was 35.86 the BMI at the start, 34.57 the BMI when they stopped taking the drug, and 35.48 after some interval? For someone of a fairly average height, say 1.86 metres (that's a little under how tall I am) a BMI of 35.86 would be 124kg which is ridiculously fat and 34.57 would be around 119.6kg so you're looking at a loss of around 4.5kg or so. That's a good shit and a haircut, in the grand scheme of things. It's fairly normal for someone's weight to fluctuate by a kilo up or down (a range of 2kg over normal) and not utterly off the map for a range of four kilos on a day-to-day basis, especially in obese people. That's why you're not supposed to keep weighing yourself and obsessing over the weight.
- rootusrootus 7mo ago
  What is it about GLP1s that bring out the kooks who suddenly think diet and exercise are the only valid medical treatment? Is it a moral issue?
  - cthalupa 7mo ago
    As best as I can tell, people are very attached to having achieved their body weight through whatever means they have determined are valid and derive self value from it, and believe that GLP-1s are cheating to achieve a result they worked harder for.
  - sublinear 7mo ago
    Unless we're talking about emergency care, most pharmaceuticals are completely unnecessary and carry serious risks. There's not a single qualified doctor out there that would promote drugs before preventative measures.
    - cthalupa 7mo ago
      Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. Saying they should try this first at this point in the game is like having your support case escalated 5 times already and them saying "have you tried turning it off and on again"
      - ErroneousBosh 7mo ago
        > Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. If it's not working for you, it may be because you haven't sorted the "diet" bit. Are you eating "low fat" or "low calorie" things? Because those are not food and they will make you fat. Eat food, just a bit less of it than you do now.
        cthalupa 7mo ago
        Obviously the calories in are greater than the calories out if the diet doesn't work. That's not the point. The point is the vast majority of overweight and obese people try to diet and do not succeed in it.
- shlant 7mo ago
  > You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often. Oh wow it's so simple! why has nobody thought of this before??
  - ErroneousBosh 7mo ago
    You've been being told this your whole life. You still think mass-marketed "low fat" foods are good for you. You still think you can pop a pill to make your problems go away.

ErroneousBosh 7mo ago

It doesn't reduce heart attack and stroke. It reduces appetite, kind of, and gives you a sore stomach while making you shit yourself inside out. All this can, with care, help contribute to weight loss. Weight loss can reduce heart attack and stroke, but GLP-1 does not. You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often.

malfist 7mo ago
Your comment is all kinds of wrong. A) it does have cardio protective effects. It does reduce your appetite, and for most people have very few side effects. If you get nausea you're titrating up too fast. Most people, because it slows gastric emptying, it doesn't make them shit themselves "inside and out". GLP1s are a decent option for treating ibs-d or bile acid issues and is better tolerated than your bile acid sequesterants. > You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often. This victim blaming advice has been given for decades and obesity rates have been climbing for decades. Only glp-1s have reduced that.
cthalupa 7mo ago
We see risk reduction for heart attack and stroke for people on GLP-1s even without weight loss, which belies the idea that the protection only comes from losing weight. Edit: In fact, from the study - BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted), Heart failure percentage was 11.57% for continued use, 12.73% for discontinued, 11.92% for interrupted NICM went 3.10% for continued, 3.36% for discontinued, 3.31% for interrupted BMI was higher for the continuing users and they still had lower heart failure and NICM rates than the discontinued and interrupted groups. (Also a bunch of other things including stroke and heart attack but I didn't want to write all of these out)
- ErroneousBosh 7mo ago
  Have you got a link to the study those figures are actually from? I'm not saying their wrong but I would like to read and understand them for myself before I change my mind. > BMI went from 35.86 (Continued) to 34.57 (Discontinued) to 35.48 (Interrupted), So, what, was 35.86 the BMI at the start, 34.57 the BMI when they stopped taking the drug, and 35.48 after some interval? For someone of a fairly average height, say 1.86 metres (that's a little under how tall I am) a BMI of 35.86 would be 124kg which is ridiculously fat and 34.57 would be around 119.6kg so you're looking at a loss of around 4.5kg or so. That's a good shit and a haircut, in the grand scheme of things. It's fairly normal for someone's weight to fluctuate by a kilo up or down (a range of 2kg over normal) and not utterly off the map for a range of four kilos on a day-to-day basis, especially in obese people. That's why you're not supposed to keep weighing yourself and obsessing over the weight.
rootusrootus 7mo ago
What is it about GLP1s that bring out the kooks who suddenly think diet and exercise are the only valid medical treatment? Is it a moral issue?
- cthalupa 7mo ago
  As best as I can tell, people are very attached to having achieved their body weight through whatever means they have determined are valid and derive self value from it, and believe that GLP-1s are cheating to achieve a result they worked harder for.
- sublinear 7mo ago
  Unless we're talking about emergency care, most pharmaceuticals are completely unnecessary and carry serious risks. There's not a single qualified doctor out there that would promote drugs before preventative measures.
  - cthalupa 7mo ago
    Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. Saying they should try this first at this point in the game is like having your support case escalated 5 times already and them saying "have you tried turning it off and on again"
    - ErroneousBosh 7mo ago
      > Pretty much every adult fat person has attempted diet and exercise to resolve their weight issue. If it's not working for you, it may be because you haven't sorted the "diet" bit. Are you eating "low fat" or "low calorie" things? Because those are not food and they will make you fat. Eat food, just a bit less of it than you do now.
      - cthalupa 7mo ago
        Obviously the calories in are greater than the calories out if the diet doesn't work. That's not the point. The point is the vast majority of overweight and obese people try to diet and do not succeed in it.
shlant 7mo ago
> You could also reduce heart attack and stroke risks by not eating crap and going for a walk every so often. Oh wow it's so simple! why has nobody thought of this before??
- ErroneousBosh 7mo ago
  You've been being told this your whole life. You still think mass-marketed "low fat" foods are good for you. You still think you can pop a pill to make your problems go away.