None of these machines actually do anything useful for protein folding or even static protein structure prediction. I have not seen any true examples of these

None of these machines actually do anything useful for protein folding or even static protein structure prediction. I have not seen any true examples of these computers generating approximate solutions for routing, scheduling or portfolio allocation that in any way justifies the cost of their R&D. I always read carefully when some company makes a deal with D-Wave about logistics optimization and it's always "this is something that could have been done on conventional computing for a reasonable price".