4 ms·
I'm not a specialist but I think there are some stapled peptides that do show appreciable uptake, so the blog post is not a complete history; this review report
by bonsai_spool 8mo ago
I'm not a specialist but I think there are some stapled peptides that do show appreciable uptake, so the blog post is not a complete history; this review reports bioavailability of up to 70% for some agents.
Nielsen DS et al. 2017. Orally Absorbed Cyclic Peptides. Chemical Reviews.
https://sci-hub.ru/10.1021/acs.chemrev.6b00838 https://sci-hub.ru/10.1021/acs.chemrev.6b00838
- JumpCrisscross 8mo ago> this review reports bioavailability of up to 70% for some agents To save us some skimming, could you specify which ones? (The review covers cyclic peptides that are absorbed by all mammals.)
- bonsai_spool 8mo agoThere are several - I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability? All peptides face similar challenges with absorption; the cyclic peptides simply have less liability to proteolysis. The text covers dozens of agents with varied biochemical properties.
- JumpCrisscross 8mo ago> I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability? I'm saying there are peptides on that list that are bioavailable to non-human mammals.