6 ms·

Independent of weight loss, semaglutide (Ozempic) improves knee osteoarthritis by cartilage restoration, in both the mouse model and a small randomized clinical

Independent of weight loss, semaglutide (Ozempic) improves knee osteoarthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial. Old thinking was the benefit of GLP-1 drugs (like Ozempic) was solely from weight loss, however studies are showing there are other unique benefits. It's probably that semaglutide reduces inflammation allowing the body to repair and improves mitochondrial function in cartilage cells.

lysace 9mo ago
Seems like a wonder drug to me. The benefits just keep piling up. Where I live (Sweden), there's a perhaps surprisingly large portion of overweight/obesese people, especially in the countryside. Semaglutide could really do wonders here for quality of life and health. Meanwhile, the newspapers keep pushing exceptional scare stories. The one that stuck with me from a few weeks ago went like 'I puked up my own poop.' Perhaps tellingly, the people they tend to feature in these stories typically aren't really overweight. It is not yet generally subsidized, unless you have a diabetes type 2 diagnose. It really should be, above some BMI (sans body builders).
- mhurron 9mo ago
  > Seems like a wonder drug to me Not really, it's that hormones don't do just one thing in the body. GLP-1 isn't just some weight management hormone. > The one that stuck with me from a few weeks ago went like 'I puked up my own poop.' That happens if you let constipation go on far too long, and is not something unique to GLP-1 meds.
  - nwienert 9mo ago
    > Not really This made me actually laugh. A drug that cures obesity and addiction alone would be a wonder drug. This one also improves about a hundred odd immune disorders, including being a better general allergy drug than just about anything. My own extremely rare and terribly painful immune disorder is basically entirely cured by it - it completely changed my life, making even sleeping far better. But not just me, I have friends who have lifelong terrible allergies gone, lifelong pack-a-day smoking addictions completely gone, and so on... "Not really" is truly either the most pessimistic take I've ever heard, or hopefully just completely misinformed.
    - mhurron 9mo ago
      > A drug that cures obesity and addiction alone would be a wonder drug. A drug that influences a hormone causing effects on everything that hormone is involved in shouldn't be considered a wonder drug, it should be expected functionality. It's only a wonder drug that does all these miraculous things if you think GLP-1 is only a weight management hormone. It's not, and you should expect effects anywhere it is involved in. A short list of tissues we know GLP-1 is involved in processes is: - heart - tongue - adipose tissue - muscles - bones - kidneys - liver - lungs Effects on these aren't miracles, they should be expected. I am happy to hear you saw so many improvements, but it's because you had an issue with a hormone that is involved in a lot of things in the body. So it was going to express a lot of problems. It's not surprising that you see a lot of improvements when you begin to manage the underlying cause.
      - nwienert 9mo ago
        The fact you assume to know what my issue is is wild, and especially since you're just completely wrong - I have no direct GLP-1 issue, my levels are normal. It's clear you have no idea what you're talking about. Every single case I'm talking about outside weight loss has nothing to do with having a deficiency of that hormone, rather it's fixed by the hormone raising. And given it was impossible to do otherwise, it's a wonder drug, of course. You don't really define wonder by how simple it is, but by the effects, which are tremendously beneficial to many. Further, I stand by my prediction that in the long run the vast majority of why this drug will be considered an once-a-generation discovery, is not due to weight loss or appetite control, but in fact it's seeming broad spectrum benefits across many systems. And actually your list of effects it has are interesting, because if you investigate deeply the studies published, you'll find that the results are overwhelmingly positive - brain, heart, many organs.
- gib444 9mo ago
  The constipation is REAL though. Like 10 plus days real. That scare story might be extreme but severe constipation is pretty common (and fecal vomiting can be a result of extreme constipation/impaction I believe)
  - lvspiff 9mo ago
    I've been taking the pill form of magnesium citrate and it helped SOO much im back to every day to every other day
    - gib444 9mo ago
      Nice. I added quite a lot of powder magnesium to my morning shake, did nothing.
      - deleted 9mo ago
        [deleted]
      - radlad 9mo ago
        You mentioned elsewhere that milk of magnesia worked, so is it possible that you received a bunk product? I know this is a common issue with supplements and there are some neutral third-party test labs for this.
        gib444 9mo ago
        Possibly but it was from a family run company in Wales with a good reputation
    - Dma54rhs 9mo ago
      Some forms of magnesium trigger more stool my movement than others. And there are many forms. I had opposite problem with it, tried ti find what won't cause it since I have a problem with it too behind with. Also sour kraut triggers me almost always and instant toilet break.
  - deleted 9mo ago
    [deleted]
- RobotToaster 9mo ago
  I keep expecting for them to discover some horrible side effect. I wonder if people thought the same when they discovered antibiotics though.
  - foxyv 9mo ago
    To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.
  - deleted 9mo ago
    [deleted]
  - JumpCrisscross 9mo ago
    Or like Vitamin C. There aren’t side effects to fixing a vitamin deficiency. This increasingly, to me, looks like that. (There are absolutely bad effects from overdoing it.)
    - ViktorRay 9mo ago
      Hey just want to add something. Vitamin C is a water soluble vitamin. It’s pretty damn hard to get Vitamin C toxicity from overconsumption. It’s not really something to worry about. This is true for all the water soluble vitamins. This isn’t true for the fat soluble vitamins. Those are Vitamin A, Vitamin E, Vitamin K and Vitamin D. You can overdose and get toxicity if you consume too much of these. For Vitamin D you can’t overdose from what your body generates from the skin but you can from the oral forms.
      - RobotToaster 9mo ago
        My understanding is it's virtually impossible to overdose vitamin K (without injecting it anyway), and pretty difficult to do so with Vitamin D.
  - nradov 9mo ago
- stavros 9mo ago
  For me, it really is a wonder drug. My blood test results were stellar when the drug worked for me. Unfortunately, with me, it either works and I get side effects, or it doesn't work at all. I feel minimal effects (and almost no weight loss) even on a 10mg dose.
  - r00fus 9mo ago
    Have you considered tirzepatide (ie, Zepbound/Mounjaro)? I know several people who responded poorly to Wegovy who did great on Zep.
    - stavros 9mo ago
      Yes, neither works for me. I managed to tolerate tirzepatide better (once), but it barely works at that point.
- autoexec 9mo ago
  > Seems like a wonder drug to me. The benefits just keep piling up. That's a massive red flag. It's a common sign of snake oil when something claims to be the cure for a ton of completely unrelated conditions. While I do think these drugs are actually effective at some things, I also wonder how much they're being overprescribed already. It seems like there's a massive push to try to get insurance to cover the drug for just about anything and everything. I've never seen a drug advertised as aggressively either. The drug is helping people and improving lives and that's a good thing, but I'm not sure how much of the attention on this drug is just a massive scheme by phrama companies to get sales and how careful doctors and patients are being.
  - MattGaiser 9mo ago
    > It's a common sign of snake oil when something claims to be the cure for a ton of completely unrelated conditions. Except this is coming from the opposite direction. The drug is being noticed to seemingly cure unrelated conditions. The vendor is not selling it as that.
    - meatmanek 9mo ago
      There's always the chance that the manufacturers are behind some of these stories -- funding studies to find new markets, astroturfing success stories, etc.
    - autoexec 9mo ago
      Although I can't say it's what happened in this case, I suspect that the drug companies have a hand in some of the research showing the unexpected benefits of their product. While they do have to be careful about what they claim the drug does in conventional advertising, studies suggesting various benefits for this drug get a lot of attention in the media.
      - cthalupa 9mo ago
        These studies have conflict of interest, funding, etc. disclosures. If it was Lilly and Novo pushing these, they'd either show up in those disclosures or you're suggesting a massive conspiracy to undermine the medical regulatory system to sell more drugs that they already have struggled to meet demand for for extended periods of time. Why would they kill a golden goose that shows no signs of stopping it's egg laying?
sReinwald 9mo ago
One thing I have noticed on Mounjaro is a (at least subjectively) significant decrease in impulse spending / buying random crap off Amazon. I have ADHD and that has been a real problem for quite a while - even with ADHD medication (Elvanse/Vyvanse in my case). The part of Mounjaro that regulates the craving side of the weight loss equation (like reducing 'food noise' and the desire for sugary and fatty foods) seems to also affect other behaviors due to Mounjaro's effect on the brain's reward circuitry. I believe there are also early preliminary studies that indicate it can help with addictions like alcoholism. Those drugs really are quite something. Shame they're so damn expensive. Insurance here in Germany is unfortunately legally prohibited from covering GLP-1 class drugs for weight loss unless you have a diabetes diagnosis.
- thinkingtoilet 9mo ago
  That would go in line with what I've read of it helping people with mild addictions.
- deinonychus 9mo ago
  That’s really neat. I’m ashamed that I have this wish that I were overweight and had an excuse to try a GLP1 just to see how it would affect my impulse control with non-food habits. I guess there’s not much stopping me from buying some unregulated drugs from the internet and self-experimenting, but I haven’t heard experiences from people deliberately using them for anything but weight.
  - papascrubs 9mo ago
    Depending on your appetite for risk, there's always the gray market. It's also a lot cheaper depending on what your insurance covers. I think I picked up a year's supply of semaglutide for under $200. I've been on some form of GLP for the last 2 years and for me there have been several tangible benefits related to ADHD. https://gray.guide https://gray.guide is a good starting point.
    - cthalupa 9mo ago

lysace 9mo ago

Seems like a wonder drug to me. The benefits just keep piling up. Where I live (Sweden), there's a perhaps surprisingly large portion of overweight/obesese people, especially in the countryside. Semaglutide could really do wonders here for quality of life and health. Meanwhile, the newspapers keep pushing exceptional scare stories. The one that stuck with me from a few weeks ago went like 'I puked up my own poop.' Perhaps tellingly, the people they tend to feature in these stories typically aren't really overweight. It is not yet generally subsidized, unless you have a diabetes type 2 diagnose. It really should be, above some BMI (sans body builders).

mhurron 9mo ago
> Seems like a wonder drug to me Not really, it's that hormones don't do just one thing in the body. GLP-1 isn't just some weight management hormone. > The one that stuck with me from a few weeks ago went like 'I puked up my own poop.' That happens if you let constipation go on far too long, and is not something unique to GLP-1 meds.
- nwienert 9mo ago
  > Not really This made me actually laugh. A drug that cures obesity and addiction alone would be a wonder drug. This one also improves about a hundred odd immune disorders, including being a better general allergy drug than just about anything. My own extremely rare and terribly painful immune disorder is basically entirely cured by it - it completely changed my life, making even sleeping far better. But not just me, I have friends who have lifelong terrible allergies gone, lifelong pack-a-day smoking addictions completely gone, and so on... "Not really" is truly either the most pessimistic take I've ever heard, or hopefully just completely misinformed.
  - mhurron 9mo ago
    > A drug that cures obesity and addiction alone would be a wonder drug. A drug that influences a hormone causing effects on everything that hormone is involved in shouldn't be considered a wonder drug, it should be expected functionality. It's only a wonder drug that does all these miraculous things if you think GLP-1 is only a weight management hormone. It's not, and you should expect effects anywhere it is involved in. A short list of tissues we know GLP-1 is involved in processes is: - heart - tongue - adipose tissue - muscles - bones - kidneys - liver - lungs Effects on these aren't miracles, they should be expected. I am happy to hear you saw so many improvements, but it's because you had an issue with a hormone that is involved in a lot of things in the body. So it was going to express a lot of problems. It's not surprising that you see a lot of improvements when you begin to manage the underlying cause.
    - nwienert 9mo ago
      The fact you assume to know what my issue is is wild, and especially since you're just completely wrong - I have no direct GLP-1 issue, my levels are normal. It's clear you have no idea what you're talking about. Every single case I'm talking about outside weight loss has nothing to do with having a deficiency of that hormone, rather it's fixed by the hormone raising. And given it was impossible to do otherwise, it's a wonder drug, of course. You don't really define wonder by how simple it is, but by the effects, which are tremendously beneficial to many. Further, I stand by my prediction that in the long run the vast majority of why this drug will be considered an once-a-generation discovery, is not due to weight loss or appetite control, but in fact it's seeming broad spectrum benefits across many systems. And actually your list of effects it has are interesting, because if you investigate deeply the studies published, you'll find that the results are overwhelmingly positive - brain, heart, many organs.
gib444 9mo ago
The constipation is REAL though. Like 10 plus days real. That scare story might be extreme but severe constipation is pretty common (and fecal vomiting can be a result of extreme constipation/impaction I believe)
- lvspiff 9mo ago
  I've been taking the pill form of magnesium citrate and it helped SOO much im back to every day to every other day
  - gib444 9mo ago
    Nice. I added quite a lot of powder magnesium to my morning shake, did nothing.
    - deleted 9mo ago
      [deleted]
    - radlad 9mo ago
      You mentioned elsewhere that milk of magnesia worked, so is it possible that you received a bunk product? I know this is a common issue with supplements and there are some neutral third-party test labs for this.
      - gib444 9mo ago
        Possibly but it was from a family run company in Wales with a good reputation
  - Dma54rhs 9mo ago
    Some forms of magnesium trigger more stool my movement than others. And there are many forms. I had opposite problem with it, tried ti find what won't cause it since I have a problem with it too behind with. Also sour kraut triggers me almost always and instant toilet break.
- deleted 9mo ago
  [deleted]
RobotToaster 9mo ago
I keep expecting for them to discover some horrible side effect. I wonder if people thought the same when they discovered antibiotics though.
- foxyv 9mo ago
  To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.
- deleted 9mo ago
  [deleted]
- JumpCrisscross 9mo ago
  Or like Vitamin C. There aren’t side effects to fixing a vitamin deficiency. This increasingly, to me, looks like that. (There are absolutely bad effects from overdoing it.)
  - ViktorRay 9mo ago
    Hey just want to add something. Vitamin C is a water soluble vitamin. It’s pretty damn hard to get Vitamin C toxicity from overconsumption. It’s not really something to worry about. This is true for all the water soluble vitamins. This isn’t true for the fat soluble vitamins. Those are Vitamin A, Vitamin E, Vitamin K and Vitamin D. You can overdose and get toxicity if you consume too much of these. For Vitamin D you can’t overdose from what your body generates from the skin but you can from the oral forms.
    - RobotToaster 9mo ago
      My understanding is it's virtually impossible to overdose vitamin K (without injecting it anyway), and pretty difficult to do so with Vitamin D.
- nradov 9mo ago
stavros 9mo ago
For me, it really is a wonder drug. My blood test results were stellar when the drug worked for me. Unfortunately, with me, it either works and I get side effects, or it doesn't work at all. I feel minimal effects (and almost no weight loss) even on a 10mg dose.
- r00fus 9mo ago
  Have you considered tirzepatide (ie, Zepbound/Mounjaro)? I know several people who responded poorly to Wegovy who did great on Zep.
  - stavros 9mo ago
    Yes, neither works for me. I managed to tolerate tirzepatide better (once), but it barely works at that point.
autoexec 9mo ago
> Seems like a wonder drug to me. The benefits just keep piling up. That's a massive red flag. It's a common sign of snake oil when something claims to be the cure for a ton of completely unrelated conditions. While I do think these drugs are actually effective at some things, I also wonder how much they're being overprescribed already. It seems like there's a massive push to try to get insurance to cover the drug for just about anything and everything. I've never seen a drug advertised as aggressively either. The drug is helping people and improving lives and that's a good thing, but I'm not sure how much of the attention on this drug is just a massive scheme by phrama companies to get sales and how careful doctors and patients are being.
- MattGaiser 9mo ago
  > It's a common sign of snake oil when something claims to be the cure for a ton of completely unrelated conditions. Except this is coming from the opposite direction. The drug is being noticed to seemingly cure unrelated conditions. The vendor is not selling it as that.
  - meatmanek 9mo ago
    There's always the chance that the manufacturers are behind some of these stories -- funding studies to find new markets, astroturfing success stories, etc.
  - autoexec 9mo ago
    Although I can't say it's what happened in this case, I suspect that the drug companies have a hand in some of the research showing the unexpected benefits of their product. While they do have to be careful about what they claim the drug does in conventional advertising, studies suggesting various benefits for this drug get a lot of attention in the media.
    - cthalupa 9mo ago
      These studies have conflict of interest, funding, etc. disclosures. If it was Lilly and Novo pushing these, they'd either show up in those disclosures or you're suggesting a massive conspiracy to undermine the medical regulatory system to sell more drugs that they already have struggled to meet demand for for extended periods of time. Why would they kill a golden goose that shows no signs of stopping it's egg laying?

sReinwald 9mo ago

One thing I have noticed on Mounjaro is a (at least subjectively) significant decrease in impulse spending / buying random crap off Amazon. I have ADHD and that has been a real problem for quite a while - even with ADHD medication (Elvanse/Vyvanse in my case). The part of Mounjaro that regulates the craving side of the weight loss equation (like reducing 'food noise' and the desire for sugary and fatty foods) seems to also affect other behaviors due to Mounjaro's effect on the brain's reward circuitry. I believe there are also early preliminary studies that indicate it can help with addictions like alcoholism. Those drugs really are quite something. Shame they're so damn expensive. Insurance here in Germany is unfortunately legally prohibited from covering GLP-1 class drugs for weight loss unless you have a diabetes diagnosis.

thinkingtoilet 9mo ago
That would go in line with what I've read of it helping people with mild addictions.
deinonychus 9mo ago
That’s really neat. I’m ashamed that I have this wish that I were overweight and had an excuse to try a GLP1 just to see how it would affect my impulse control with non-food habits. I guess there’s not much stopping me from buying some unregulated drugs from the internet and self-experimenting, but I haven’t heard experiences from people deliberately using them for anything but weight.
- papascrubs 9mo ago
  Depending on your appetite for risk, there's always the gray market. It's also a lot cheaper depending on what your insurance covers. I think I picked up a year's supply of semaglutide for under $200. I've been on some form of GLP for the last 2 years and for me there have been several tangible benefits related to ADHD. https://gray.guide https://gray.guide is a good starting point.
  - cthalupa 9mo ago