3 ms·
> Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults. > In skeletal muscle, this decline is largely driven by impa
by TacticalCoder 8mo ago
> Aging muscles heal more slowly after injury—a frustrating reality familiar to many older adults.
> In skeletal muscle, this decline is largely driven by impaired function of muscle stem cells (MuSCs)
I take it that as mitosis (cell division) gets slower with age, there's also simply no way aging muscles could potentially not heal more slowly?
So slower mitosis and then in addition to that muscle cells going into a "less repair, more survival" mode. Darn, sucks to get old.
- lumost 8mo agoNo known mechanism, but cross species checks would imply that the schedule was evolved and has some control mechanism. Species that evolved before the Devonian period tend not to age and instead grow through their entire lives. There is no mechanistic understanding for the wild variation in species lifespans. So the natural question in these studies is what would happen if we simply told the muscles not to age this way. It’s plausible that this aging schedule evolved due to other factors independent of the biological constraints. It’s also plausible that evolution removed some other important components for longer lived stem cells.
- nanomonkey 8mo agoInteresting, the Devonian also appears to be the period at which fish started sporting limb like appendages and muscle structures, and other animals started to explore land. Perhaps unlimited body growth doesn't work well for animals not entirely supported by water.
- Nevermark 8mo agoInterestingly, the limbless boa constrictor's growth slows, but never stops.
- Nevermark 8mo agoI misread that as the "Denisovan period" and found it interesting that in addition to Homo Floresiensis Hobbits, there might have been arbitrarily large Denisova Hominin giants. Oh well. I will have to be satisfied with Andre the Giant.