2 ms·

This isn't quite as bad as the garden variety "in mice" studies: > The combination therapy also led to significant regression in genetically engineered mouse t

This isn't quite as bad as the garden variety "in mice" studies: > The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice, known as patient-derived tumour xenografts (PDX).

ramesh31 9mo ago
>"The combination therapy also led to significant regression in genetically engineered mouse tumours and in human cancer tissues grown in lab mice" Required XKCD: https://xkcd.com/1217/ https://xkcd.com/1217/
- apparent 9mo ago
  Is PDX considered to be illegitimate? Would be curious to know if prior studies that showed success with PDX methods ultimately resulted in useful therapeutics.
  - tiahura 9mo ago
    Vorinostat
stultissimus 9mo ago
PDX is a double edged sword. Human tumors are engrafted into mice with no immune system. Immune-cancer interface is incredibly important, yet completely lacking in these models. Consider that some of the greatest cancer drugs ever work specifically on the immune system (e.g. checkpoint inhibitors like Keytruda).
- DennisP 9mo ago
  A drug that works even without help from the immune system seems like it might be even better. It's hard to imagine how the immune system might interfere, since it doesn't interfere with other drugs.
- deleted 9mo ago
  [deleted]