7 ms·

Cardiovascular disease is a solved problem

84 points by brandonb 10mo ago

sghiassy 10mo ago
I wonder how many Cardiologists would call cardiovascular disease “a solved problem” My bet is close to none
- agumonkey 10mo ago
  following a few cardiology conference i tend to agree with you, far from this sadly
- noitpmeder 10mo ago
  I mean their livelihood is predicated on it not being solved for a portion of the population
  - medstrom 10mo ago
    There is plenty more for a cardiologist to do even if they solve the most pressing current problems. Hard to run out of puzzles in biology.
- bilsbie 10mo ago
  Ask yourself what happens to them if it’s solved.
- deleted 10mo ago
  [deleted]
- WillAdams 10mo ago
  Ages ago, I used to do the typesetting for the _Cardiosource Review Journal_ (lived my life around the publishing schedule because no one else was able to run a WordBASIC macro to do initial formatting, import that into a page layout program, process all the graphics and place them, and generate page proofs early enough that it could be proofed and corrected with a 24hr. turn-around until a postal rate increase killed it) --- cardiologists seem very big on data/analysis, moreso than most other medical fields.
- Aurornis 10mo ago
  “Solved problem” is too strong of language, but the cardiologists I follow are generally open about the idea that we have enough tools and knowledges to reasonably prevent and manage it the average person. Even without medications, we’ve had enough knowledge about diet and lifestyle factors that the average person (excluding generic abnormalities that lead to abnormally high risk) could reasonably avoid heart disease through lifestyle and diet alone. That’s easier said than done for a lot of people in the modern world, so it’s good that we have a few different medications on top of that knowledge.
  - dubeye 10mo ago
    the cardiologist I pay, visit and follow, would likely advise perfect diet and excercise will only reduce risk not eliminate it. So it comes down to definition of 'resaonably'. diet and excercise will 'reasonably' reduce risk of most disease.
    - Aurornis 10mo ago
      > will only reduce risk not eliminate it. Same with medications? It’s well known that medications don’t eliminate risk. For the average person without genetic outlier risk, perfect diet and exercise would definitely make heart disease a non-issue in their lifetime. The risk your cardiologist is talking about is probably the risk that you have one of those genetic outlier conditions that require medication regardless of diet.
- brandonb 10mo ago
  I think there's a a bit of a paradox here: cardiovascular disease is solved biomedically, yet still remains the #1 cause of death worldwide. From a biomedical standpoint, we have highly accurate biomarkers (e.g., ApoB, Lp(a), hs-CRP), long-term risk prediction models, knowledge of nutritional biochemstry, and next generation drugs like PCSK9 inhibitors and lepodisiran that can lower ApoB and Lp(a) by 90%. So there's no fundamental reason why cardiovascular disease has to be in even the top 10 causes of death. Practically speaking, providing guideline-recommended preventive care would require ~27 hours per doctor per day. And the incentives are misaligned: health systems profit when hospital beds are full, so they lack the business model to actually invest in prevention. So it's a clear illustration of a systematic gap between research and care delivery.
  - lm28469 10mo ago
    > I think there's a a bit of a paradox here: cardiovascular disease is solved biomedically, yet still remains the #1 cause of death worldwide. Because most people don't give a shit about their health, no amount of pills will save you if you eat like the average american.
    - vladgur 10mo ago
      I also think that many people don’t know - I would wager for men that a significant percentage of them do not go to see a doctor preventively unless injured or sick and not that may know their blood pressure or cholesterol trends
  - loeg 10mo ago
    Well, and everyone knows they should exercise, and many know they should avoid dietary saturated fats, but most people neither exercise nor avoid highly fatty foods.
  - vladgur 10mo ago
    Thanks for sharing this and empowering others to improve their heart health outcomes. I’m not in love with the idea of sharing my biomarkers with multiple health-tech companies and really want a self-hosted solution to import biomarkers from multiple sources such as Apple Health, arbitrary csv and jsons while avoiding duplication. Claude Code is something that will make this dream a reality for me pretty soon. Do you have any tips on biomarker data design or import gotchas?
- lm28469 10mo ago
  It's almost entirely a lifestyle problem. Shit diet, lack of exercise, obesity, &c. Overlap maps of obesity and cardiovascular deaths, they're virtually the same https://ec.europa.eu/eurostat/documents/4187653/10321616/deaths+due+to+coronary+diseases+map.png https://ec.europa.eu/eurostat/documents/4187653/10321616/dea... https://ec.europa.eu/eurostat/statistics-explained/images/thumb/a/a2/Share_of_overweight_people_aged_16_years_or_over%2C_2022_%28%25%29_Health2024.png/800px-Share_of_overweight_people_aged_16_years_or_over%2C_2022_%28%25%29_Health2024.png https://ec.europa.eu/eurostat/statistics-explained/images/th...
daveguy 10mo ago
Well, that's certainly a ... hypothesis. And an N of 1 "experiment" on whoever wrote this.
AllegedAlec 10mo ago
[flagged]
agumonkey 10mo ago
archive just in case https://archive.ph/Od1VS https://archive.ph/Od1VS anybody in the medical field able to give some report on state of the art CV research ?
- brandonb 10mo ago
  I think the title is deliberately provocative, but they're not wrong. Heart disease is largely solvable from a biomedical standpoint: we have accurate biomarkers (e.g., ApoB, Lp(a), hs-CRP), long-term risk prediction models, precision nutrition, and highly effective next-generation drugs (PCSK9 inhibitors, lepodisiran, etc). But practically speaking, heart disease remains the #1 cause of death due to bottlenecks in care delivery: e.g., 46% U.S. counties have no cardiologists, providing guideline-recommended preventive care would require ~27 hours per doctor per day, and incentives are misaligned (health systems profit when hospital beds are full, not from prevention).
  - kiba 10mo ago
    But practically speaking, heart disease remains the #1 cause of death due to bottlenecks in care delivery: e.g., 46% U.S. counties have no cardiologists, providing guideline-recommended preventive care would require ~27 hours per doctor per day, and incentives are misaligned (health systems profit when hospital beds are full, not from prevention). Supposed that we have an incentive aligned health care system. What would that look like? I think one outcome is that the healthcare system eventually expands due to population growth and less death. Accidents happen, rare cases become more common, even as we get good at fixing or preventing them.
  - unsupp0rted 10mo ago
    Is it naive to say: 1. Check your ApoB, Lp(a), hs-CRP every 4 months 2. Feed that into a current-gen LLM and ask it to tell you what drugs to take and at what dosages Would that solve about 90% of the issue?
    - brandonb 10mo ago
      I started a company that does exactly that (except we also have doctors who can prescribe the medications, not just LLMs). So I don't think the approach you describe is naive, but others might. :)
ericd 10mo ago
Hm, so statins for everyone? What’re the downsides?
- amanaplanacanal 10mo ago
  Possible side effects include muscle damage, liver damage, and type 2 diabetes.
- yojo 10mo ago
  I’m old enough that my parents/spouse’s parents are all on statins. They all report side-effects, mostly digestive issues. I’ll eat a healthy diet, exercise, and live a life without persistent diarrhea. I’ll take statins if/when they are medically necessary, and no sooner.
- brandonb 10mo ago
  The main side effects of statins are muscle pain and brain fog (from some statins -- others cross the blood-brain barrier much less). The benefit of statins is to not only lower LDL cholesterol, but also inflammation, which is now actually a stronger risk factor for cardiovascular disease than cholesterol: https://www.empirical.health/blog/inflammation-and-heart-health/ https://www.empirical.health/blog/inflammation-and-heart-hea... Layering PCSK9 inhibitors, ezetimibe, and statins can lower ApoB/LDL cholesterol by 85–90%, which would have been unheard of until recently. On the horizon, drugs in clinical trials lower Lp(a) (the strongest hereditary risk factor for heart disease) by 94%. Currently, there are four RNA-based drugs in trials that effectively silence the gene that makes Lp(a) in liver cells: lepodisiran, olpasiran, pelacarsen, and zerlasiran.
  - gabrielsroka 10mo ago
    > About 10% of people develop muscle aches > Concerns about statin effects on the brain, such as cognitive impairment or dementia, are unfounded https://www.health.harvard.edu/heart-health/what-are-the-risks-from-taking-statins https://www.health.harvard.edu/heart-health/what-are-the-ris...
  - CalChris 10mo ago
inglor_cz 10mo ago
It is very much not a solved problem unless you can actually cure it in existing patients, e.g. reduce or remove the extant plaques from their blood vessels. This is not pedantry, this is a vital problem of hundreds of millions of currently living people, many of which don't even know their own status. I believe this can be done in the near future, there are some interesting initiatives in this direction, but it is very much not a solved problem.
ashleyn 10mo ago
Obesity, junk food addiction, and chronic inactivity still remain unsolved as ever.
- kccqzy 10mo ago
  I agree with you, but I suppose the point of the article is that we can solve cardiovascular disease without first solving obesity or chronic inactivity.
- justinator 10mo ago
  GLP-1's baby.
- loeg 10mo ago
  Obesity is solved! Tirzepatide.
WhatsTheBigIdea 10mo ago
This paper's core idea is based on the assumption that circulating LDL is the cause of heart disease. That assumption is false. Taking satins is proven to reduce heart disease rates, but there are lots of other drugs that lower LDL... many with much more efficacy than satins. These non-satin drugs do not reduce heart disease rates significantly. There something else going on here. High LDL is correlated with the development of heart disease, but it does not cause heart disease. Satins do reduce the risk of heart disease and they do reduce LDL, but their positive effect on heart disease rates is not caused by reduced LDL.
- thomassmith65 10mo ago
  *statins?
  - blell 10mo ago
    The fact that this word is misspelt every single time makes me want to dismiss the entirety of the comment.
    - mark-r 10mo ago
      My browser underlines the word statin to indicate a misspelling, but does not underline satin. We've been trained to believe the computer is always right when it flags an error, but unfortunately it's not 100% accurate.
- medstrom 10mo ago
  > High LDL is correlated with the development of heart disease, but it does not cause heart disease. You realize this sentence is an oxymoron? Unless you meant to say "it does not cause the development of heart disease". I agree correlation is not causation.
  - elromulous 10mo ago
    You realize correlation does not imply causation? Edit: this was written before OP edited their comment
paxys 10mo ago
"Hunger is a solved problem. We just need to give enough food to everyone!"
MPSimmons 10mo ago
>Lp(a) levels are almost purely genetically determined and so elevated Lp(a) is essentially due to a poor roll of the genetic dice... For simplicity, we will devote little further attention to either of these secondary risk factors” As someone who rolled poorly on those genetic dice, I would like to complain. But also, disregarding a factor that impacts 20%[1] of the population seems disingenuous. [1] - https://familyheart.org/family-sharing-tools/high-lpa-family-tools https://familyheart.org/family-sharing-tools/high-lpa-family...
- brandonb 10mo ago
  Lepodisiran has reduced Lp(a) by 94% in clinical trails. After it gets approved, IMO the author should re-write this section.
dmead 10mo ago
Valve failure often has nothing to do with diet. This is junk.
- OutOfHere 10mo ago
  There are other cardiac failure modes too, for example electrical and hypertrophy.
deleted 10mo ago
[deleted]
rubing 10mo ago
[dead]
bilsbie 10mo ago
Here’s a counterpoint if anyone is interested: https://www.midwesterndoctor.com/p/why-are-statins-so-dangerous https://www.midwesterndoctor.com/p/why-are-statins-so-danger... I’m not saying either side is right but when it comes to your health why not evaluate as many opinions as possible.
- hombre_fatal 10mo ago
  I wish the “counter points” to my claims were always as bad as that link. It has a little bit of everything, from Fauci to seed oils to a Joe Rogan video.
- loeg 10mo ago
  Your article starts by comparing the harms of statins to the harms of scary COVID vaccines. I'm not sure it's very credible.
- graboy 10mo ago
  Here is the chief editor of JAMA internal medicine arguing there is not enough evidence to prescribe statins for primary prevention in those 40+: https://www.natap.org/2016/HIV/ied160021.pdf https://www.natap.org/2016/HIV/ied160021.pdf
Finbarr 10mo ago
Very similar to https://myticker.com/ https://myticker.com/ though a little denser.
- vladgur 10mo ago
  Thanks for sharing this — amazing resource and resembles my experience with US health care. I recently asked my doctor at Stanford - a pretty expensive hospital but one of the top cardio hospitals in the country - to get me an APoB test. He said that it may not be covered by insurance. So instead I spend $360 or so on a year worth of biomarkers from Function Health that included ApoB and others
unsupp0rted 10mo ago
Commenters are really piling on, without, it seems, reading the article. The author addresses a lot of the obvious gotcha points I see in the comments. Although I don't think the author realistically explores the downsides of statin use, papering over the common side-effects.
- Modified3019 10mo ago
  Dramatic clickbait titles should expect to get responses that match.
onesandofgrain 10mo ago
It was my understanding that circulating free triglycerides and LpA were the main risk factors for CAD and not LDL. In addition to AGEs?
skywhopper 10mo ago
This is dangerous nonsense and should be removed from the HN front page.
raphman 10mo ago
Some information on the author: - The blog seems to be associated with this Twitter account: https://x.com/sichuan_mala https://x.com/sichuan_mala. That person seems to be a good friend of Cremieux¹. - The article seems to have originally been published/unpublished in 2024 https://x.com/cremieuxrecueil/status/1922743591924899962 https://x.com/cremieuxrecueil/status/1922743591924899962 - It was only re-uploaded in September 2025 (?). There's some discussion of the claims under a tweet by Cremieux who announced the re-upload: https://x.com/cremieuxrecueil/status/1974990143544287715 https://x.com/cremieuxrecueil/status/1974990143544287715 ¹) FWIW: https://en.wikipedia.org/wiki/Jordan_Lasker https://en.wikipedia.org/wiki/Jordan_Lasker
Ifkaluva 10mo ago
Why was this flagged? I was under the impression that the content of the article reflects the current mainstream medical view.

84 points by brandonb 10mo ago

sghiassy 10mo ago

I wonder how many Cardiologists would call cardiovascular disease “a solved problem” My bet is close to none

agumonkey 10mo ago
following a few cardiology conference i tend to agree with you, far from this sadly
noitpmeder 10mo ago
I mean their livelihood is predicated on it not being solved for a portion of the population
- medstrom 10mo ago
  There is plenty more for a cardiologist to do even if they solve the most pressing current problems. Hard to run out of puzzles in biology.
bilsbie 10mo ago
Ask yourself what happens to them if it’s solved.
deleted 10mo ago
[deleted]
WillAdams 10mo ago
Ages ago, I used to do the typesetting for the _Cardiosource Review Journal_ (lived my life around the publishing schedule because no one else was able to run a WordBASIC macro to do initial formatting, import that into a page layout program, process all the graphics and place them, and generate page proofs early enough that it could be proofed and corrected with a 24hr. turn-around until a postal rate increase killed it) --- cardiologists seem very big on data/analysis, moreso than most other medical fields.
Aurornis 10mo ago
“Solved problem” is too strong of language, but the cardiologists I follow are generally open about the idea that we have enough tools and knowledges to reasonably prevent and manage it the average person. Even without medications, we’ve had enough knowledge about diet and lifestyle factors that the average person (excluding generic abnormalities that lead to abnormally high risk) could reasonably avoid heart disease through lifestyle and diet alone. That’s easier said than done for a lot of people in the modern world, so it’s good that we have a few different medications on top of that knowledge.
- dubeye 10mo ago
  the cardiologist I pay, visit and follow, would likely advise perfect diet and excercise will only reduce risk not eliminate it. So it comes down to definition of 'resaonably'. diet and excercise will 'reasonably' reduce risk of most disease.
  - Aurornis 10mo ago
    > will only reduce risk not eliminate it. Same with medications? It’s well known that medications don’t eliminate risk. For the average person without genetic outlier risk, perfect diet and exercise would definitely make heart disease a non-issue in their lifetime. The risk your cardiologist is talking about is probably the risk that you have one of those genetic outlier conditions that require medication regardless of diet.
brandonb 10mo ago
I think there's a a bit of a paradox here: cardiovascular disease is solved biomedically, yet still remains the #1 cause of death worldwide. From a biomedical standpoint, we have highly accurate biomarkers (e.g., ApoB, Lp(a), hs-CRP), long-term risk prediction models, knowledge of nutritional biochemstry, and next generation drugs like PCSK9 inhibitors and lepodisiran that can lower ApoB and Lp(a) by 90%. So there's no fundamental reason why cardiovascular disease has to be in even the top 10 causes of death. Practically speaking, providing guideline-recommended preventive care would require ~27 hours per doctor per day. And the incentives are misaligned: health systems profit when hospital beds are full, so they lack the business model to actually invest in prevention. So it's a clear illustration of a systematic gap between research and care delivery.
- lm28469 10mo ago
  > I think there's a a bit of a paradox here: cardiovascular disease is solved biomedically, yet still remains the #1 cause of death worldwide. Because most people don't give a shit about their health, no amount of pills will save you if you eat like the average american.
  - vladgur 10mo ago
    I also think that many people don’t know - I would wager for men that a significant percentage of them do not go to see a doctor preventively unless injured or sick and not that may know their blood pressure or cholesterol trends
- loeg 10mo ago
  Well, and everyone knows they should exercise, and many know they should avoid dietary saturated fats, but most people neither exercise nor avoid highly fatty foods.
- vladgur 10mo ago
  Thanks for sharing this and empowering others to improve their heart health outcomes. I’m not in love with the idea of sharing my biomarkers with multiple health-tech companies and really want a self-hosted solution to import biomarkers from multiple sources such as Apple Health, arbitrary csv and jsons while avoiding duplication. Claude Code is something that will make this dream a reality for me pretty soon. Do you have any tips on biomarker data design or import gotchas?
lm28469 10mo ago
It's almost entirely a lifestyle problem. Shit diet, lack of exercise, obesity, &c. Overlap maps of obesity and cardiovascular deaths, they're virtually the same https://ec.europa.eu/eurostat/documents/4187653/10321616/deaths+due+to+coronary+diseases+map.png https://ec.europa.eu/eurostat/documents/4187653/10321616/dea... https://ec.europa.eu/eurostat/statistics-explained/images/thumb/a/a2/Share_of_overweight_people_aged_16_years_or_over%2C_2022_%28%25%29_Health2024.png/800px-Share_of_overweight_people_aged_16_years_or_over%2C_2022_%28%25%29_Health2024.png https://ec.europa.eu/eurostat/statistics-explained/images/th...

daveguy 10mo ago

Well, that's certainly a ... hypothesis. And an N of 1 "experiment" on whoever wrote this.

AllegedAlec 10mo ago

[flagged]

agumonkey 10mo ago

archive just in case https://archive.ph/Od1VS https://archive.ph/Od1VS anybody in the medical field able to give some report on state of the art CV research ?

brandonb 10mo ago
I think the title is deliberately provocative, but they're not wrong. Heart disease is largely solvable from a biomedical standpoint: we have accurate biomarkers (e.g., ApoB, Lp(a), hs-CRP), long-term risk prediction models, precision nutrition, and highly effective next-generation drugs (PCSK9 inhibitors, lepodisiran, etc). But practically speaking, heart disease remains the #1 cause of death due to bottlenecks in care delivery: e.g., 46% U.S. counties have no cardiologists, providing guideline-recommended preventive care would require ~27 hours per doctor per day, and incentives are misaligned (health systems profit when hospital beds are full, not from prevention).
- kiba 10mo ago
  But practically speaking, heart disease remains the #1 cause of death due to bottlenecks in care delivery: e.g., 46% U.S. counties have no cardiologists, providing guideline-recommended preventive care would require ~27 hours per doctor per day, and incentives are misaligned (health systems profit when hospital beds are full, not from prevention). Supposed that we have an incentive aligned health care system. What would that look like? I think one outcome is that the healthcare system eventually expands due to population growth and less death. Accidents happen, rare cases become more common, even as we get good at fixing or preventing them.
- unsupp0rted 10mo ago
  Is it naive to say: 1. Check your ApoB, Lp(a), hs-CRP every 4 months 2. Feed that into a current-gen LLM and ask it to tell you what drugs to take and at what dosages Would that solve about 90% of the issue?
  - brandonb 10mo ago
    I started a company that does exactly that (except we also have doctors who can prescribe the medications, not just LLMs). So I don't think the approach you describe is naive, but others might. :)

ericd 10mo ago

Hm, so statins for everyone? What’re the downsides?

amanaplanacanal 10mo ago
Possible side effects include muscle damage, liver damage, and type 2 diabetes.
yojo 10mo ago
I’m old enough that my parents/spouse’s parents are all on statins. They all report side-effects, mostly digestive issues. I’ll eat a healthy diet, exercise, and live a life without persistent diarrhea. I’ll take statins if/when they are medically necessary, and no sooner.
brandonb 10mo ago
The main side effects of statins are muscle pain and brain fog (from some statins -- others cross the blood-brain barrier much less). The benefit of statins is to not only lower LDL cholesterol, but also inflammation, which is now actually a stronger risk factor for cardiovascular disease than cholesterol: https://www.empirical.health/blog/inflammation-and-heart-health/ https://www.empirical.health/blog/inflammation-and-heart-hea... Layering PCSK9 inhibitors, ezetimibe, and statins can lower ApoB/LDL cholesterol by 85–90%, which would have been unheard of until recently. On the horizon, drugs in clinical trials lower Lp(a) (the strongest hereditary risk factor for heart disease) by 94%. Currently, there are four RNA-based drugs in trials that effectively silence the gene that makes Lp(a) in liver cells: lepodisiran, olpasiran, pelacarsen, and zerlasiran.
- gabrielsroka 10mo ago
  > About 10% of people develop muscle aches > Concerns about statin effects on the brain, such as cognitive impairment or dementia, are unfounded https://www.health.harvard.edu/heart-health/what-are-the-risks-from-taking-statins https://www.health.harvard.edu/heart-health/what-are-the-ris...
- CalChris 10mo ago

inglor_cz 10mo ago

It is very much not a solved problem unless you can actually cure it in existing patients, e.g. reduce or remove the extant plaques from their blood vessels. This is not pedantry, this is a vital problem of hundreds of millions of currently living people, many of which don't even know their own status. I believe this can be done in the near future, there are some interesting initiatives in this direction, but it is very much not a solved problem.

ashleyn 10mo ago

Obesity, junk food addiction, and chronic inactivity still remain unsolved as ever.

kccqzy 10mo ago
I agree with you, but I suppose the point of the article is that we can solve cardiovascular disease without first solving obesity or chronic inactivity.
justinator 10mo ago
GLP-1's baby.
loeg 10mo ago
Obesity is solved! Tirzepatide.

WhatsTheBigIdea 10mo ago

This paper's core idea is based on the assumption that circulating LDL is the cause of heart disease. That assumption is false. Taking satins is proven to reduce heart disease rates, but there are lots of other drugs that lower LDL... many with much more efficacy than satins. These non-satin drugs do not reduce heart disease rates significantly. There something else going on here. High LDL is correlated with the development of heart disease, but it does not cause heart disease. Satins do reduce the risk of heart disease and they do reduce LDL, but their positive effect on heart disease rates is not caused by reduced LDL.

thomassmith65 10mo ago
*statins?
- blell 10mo ago
  The fact that this word is misspelt every single time makes me want to dismiss the entirety of the comment.
  - mark-r 10mo ago
    My browser underlines the word statin to indicate a misspelling, but does not underline satin. We've been trained to believe the computer is always right when it flags an error, but unfortunately it's not 100% accurate.
medstrom 10mo ago
> High LDL is correlated with the development of heart disease, but it does not cause heart disease. You realize this sentence is an oxymoron? Unless you meant to say "it does not cause the development of heart disease". I agree correlation is not causation.
- elromulous 10mo ago
  You realize correlation does not imply causation? Edit: this was written before OP edited their comment

paxys 10mo ago

"Hunger is a solved problem. We just need to give enough food to everyone!"

MPSimmons 10mo ago

>Lp(a) levels are almost purely genetically determined and so elevated Lp(a) is essentially due to a poor roll of the genetic dice... For simplicity, we will devote little further attention to either of these secondary risk factors” As someone who rolled poorly on those genetic dice, I would like to complain. But also, disregarding a factor that impacts 20%[1] of the population seems disingenuous. [1] - https://familyheart.org/family-sharing-tools/high-lpa-family-tools https://familyheart.org/family-sharing-tools/high-lpa-family...

brandonb 10mo ago
Lepodisiran has reduced Lp(a) by 94% in clinical trails. After it gets approved, IMO the author should re-write this section.

dmead 10mo ago

Valve failure often has nothing to do with diet. This is junk.

OutOfHere 10mo ago
There are other cardiac failure modes too, for example electrical and hypertrophy.

deleted 10mo ago

[deleted]

rubing 10mo ago

[dead]

bilsbie 10mo ago

Here’s a counterpoint if anyone is interested: https://www.midwesterndoctor.com/p/why-are-statins-so-dangerous https://www.midwesterndoctor.com/p/why-are-statins-so-danger... I’m not saying either side is right but when it comes to your health why not evaluate as many opinions as possible.

hombre_fatal 10mo ago
I wish the “counter points” to my claims were always as bad as that link. It has a little bit of everything, from Fauci to seed oils to a Joe Rogan video.
loeg 10mo ago
Your article starts by comparing the harms of statins to the harms of scary COVID vaccines. I'm not sure it's very credible.
graboy 10mo ago
Here is the chief editor of JAMA internal medicine arguing there is not enough evidence to prescribe statins for primary prevention in those 40+: https://www.natap.org/2016/HIV/ied160021.pdf https://www.natap.org/2016/HIV/ied160021.pdf

Finbarr 10mo ago

Very similar to https://myticker.com/ https://myticker.com/ though a little denser.

vladgur 10mo ago
Thanks for sharing this — amazing resource and resembles my experience with US health care. I recently asked my doctor at Stanford - a pretty expensive hospital but one of the top cardio hospitals in the country - to get me an APoB test. He said that it may not be covered by insurance. So instead I spend $360 or so on a year worth of biomarkers from Function Health that included ApoB and others

unsupp0rted 10mo ago

Commenters are really piling on, without, it seems, reading the article. The author addresses a lot of the obvious gotcha points I see in the comments. Although I don't think the author realistically explores the downsides of statin use, papering over the common side-effects.

Modified3019 10mo ago
Dramatic clickbait titles should expect to get responses that match.

onesandofgrain 10mo ago

It was my understanding that circulating free triglycerides and LpA were the main risk factors for CAD and not LDL. In addition to AGEs?

skywhopper 10mo ago

This is dangerous nonsense and should be removed from the HN front page.

raphman 10mo ago

Some information on the author: - The blog seems to be associated with this Twitter account: https://x.com/sichuan_mala https://x.com/sichuan_mala. That person seems to be a good friend of Cremieux¹. - The article seems to have originally been published/unpublished in 2024 https://x.com/cremieuxrecueil/status/1922743591924899962 https://x.com/cremieuxrecueil/status/1922743591924899962 - It was only re-uploaded in September 2025 (?). There's some discussion of the claims under a tweet by Cremieux who announced the re-upload: https://x.com/cremieuxrecueil/status/1974990143544287715 https://x.com/cremieuxrecueil/status/1974990143544287715 ¹) FWIW: https://en.wikipedia.org/wiki/Jordan_Lasker https://en.wikipedia.org/wiki/Jordan_Lasker

Ifkaluva 10mo ago

Why was this flagged? I was under the impression that the content of the article reflects the current mainstream medical view.