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There appears to be some danger in using NAD+ without the supervision of an experienced physician. "Pieper emphasized that current over-the-counter NAD+-precur
by chasil 10mo ago
There appears to be some danger in using NAD+ without the supervision of an experienced physician.
"Pieper emphasized that current over-the-counter NAD+-precursors have been shown in animal models to raise cellular NAD+ to dangerously high levels that promote cancer."
- digitaltrees 10mo agoMost people with Alzheimer’s are older and would probably trade having their cognitive abilities back even with increased risk of cancer
- timr 10mo agoDepends entirely on the stage of the disease and the aggressiveness of the cancer! Getting an aggressive brain cancer when you had early stage Alzheimer’s [1] would be tragic. The tradeoff would be years of life. For the record, I have no idea what the actual risk tradeoff is, but the point of regulation is that nobody does. You can’t have informed consent when you can’t be informed. [1] Aside: Alzheimer’s is relatively early stage, as dementias go. It’s frequently diagnosed by onset in younger people.
- Aurornis 10mo agoThe chemical the parent comment linked is different. NAD itself isn’t usually supplemented because it’s broken down by your digestive system. So NAD precursor supplements have been available for a while: NR and NMN specifically. These are the precursors they were talking about. The actual drug used in this study has a different mechanism of action. It’s not directly available as a supplement, but like the parent commenter discovered you could technically find a chemical supply house to synthesize a tiny quantity of it.